Single-Atom Gadolinium Anchored on Graphene Quantum Dots as a Magnetic Resonance Signal Amplifier

Ding, Haizhen; Wang, Dong; Sadat, Anwar; Li, Zhenzhen; Hu, Xiaolong; Xu, Mingsheng; Morais, P.C.; Ge, Binghui; Sun, Song; Ge, Jiechao; Chen, Yan; Qian, Yinfeng; Shen, Chengliang; Shi, Xianyang; Huang, Xin; Zhang, Ren-Quan; Hong, Bo

doi:10.1021/acsabm.1c00030

Cited by 26 publications

(13 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These biocompatible quantum dots exhibited suitable magnetism characteristics, exhibiting attractive potentials for MRI of tumors . Ding et al introduced a single-atom Gd fastened onto graphene quantum dots with dendrite-like shape as NCAs for obtaining high-definition MRI, which need to be further explored for specific clinical theranostic applications. The nanosystems demonstrated a significantly enhanced longitudinal relaxivity ( r 1 = 86.08 mM –1 s –1 ) at a low Gd 3+ concentration of 2 μmol kg –1 , which was 25 times higher than the routinely applied Gd-DTPA with r 1 = 3.44 mM –1 s –1 …”

Section: Ncas For Mrimentioning

confidence: 99%

Nanoscale Contrast Agents for Magnetic Resonance Imaging: A Review

Soufi

Hekmatnia

Iravani

et al. 2022

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

Today, magnetic resonance imaging (MRI) is one of the most widely applied noninvasive clinical imaging modalities with excellent applicability in bio- and nanomedicine, particularly in specific detecting and high-quality three-dimensional imaging of tumors/cancers. In this context, the design of efficient nanoscale contrast agents (NCAs) for MRI with high magnetic relaxivity and specificity/selectivity has garnered immense interest deploying a variety of innovatively designed nanostructures. Some important characteristics of NCAs such as biocompatibility, improved relaxivity, high dispersibility, specific targeting, and low toxicity make them ideal candidates for imaging/biosensing applications. The hybridization and surface functionalization/modification of these materials by applying suitable functional groups/agents can help to improve their properties and multifunctionality. However, there is still a long way to go in the clinical applications of these nanoagents to serve as a substitute for Gd-based contrast agents or other commercial materials. Importantly, nanotoxicological and biosafety issues of these NCAs need to be systematically addressed both at pre- and clinical stages; construction of smart multifunctional NCAs with clinical diagnostic and imaging potentials is thus warranted. Herein, recent advancements related to the diagnostic and imaging applications of MRI NCAs are deliberated, focusing on important challenges and future directions.

show abstract

Section: Ncas For Mrimentioning

confidence: 99%

Nanoscale Contrast Agents for Magnetic Resonance Imaging: A Review

Soufi

Hekmatnia

Iravani

et al. 2022

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

show abstract

“…Apart from these, many researchers have synthesized GO/RGO based magnetic nanocomposite for MR imaging [ 109 , 110 , 111 ]. In addition to GO and rGO based IONPs, Gd doped graphene QDs also has been prepared and demonstrated for MR imaging [ 112 , 113 ], which could also offer good loading of imaging and drugs molecules and less toxicity to serve as a theranostic material. According to the literature the contrast agents improve the image quality and here the IONPs produce better contrast than Gd or other magnetic nanomateial composites.…”

Section: Graphene Nanocomposite Theranostics For Multimodal Imaging G...mentioning

confidence: 99%

Multimodal Imaging and Phototherapy of Cancer and Bacterial Infection by Graphene and Related Nanocomposites

2022

View full text Add to dashboard Cite

The advancements in nanotechnology and nanomedicine are projected to solve many glitches in medicine, especially in the fields of cancer and infectious diseases, which are ranked in the top five most dangerous deadly diseases worldwide by the WHO. There is great concern to eradicate these problems with accurate diagnosis and therapies. Among many developed therapeutic models, near infra-red mediated phototherapy is a non-invasive technique used to invade many persistent tumors and bacterial infections with less inflammation compared with traditional therapeutic models such as radiation therapy, chemotherapy, and surgeries. Herein, we firstly summarize the up-to-date research on graphene phototheranostics for a better understanding of this field of research. We discuss the preparation and functionalization of graphene nanomaterials with various biocompatible components, such as metals, metal oxides, polymers, photosensitizers, and drugs, through covalent and noncovalent approaches. The multifunctional nanographene is used to diagnose the disease with confocal laser scanning microscopy, magnetic resonance imaging computed tomography, positron emission tomography, photoacoustic imaging, Raman, and ToF-SMIS to visualize inside the biological system for imaging-guided therapy are discussed. Further, treatment of disease by photothermal and photodynamic therapies against different cancers and bacterial infections are carefully conferred herein along with challenges and future perspectives.

show abstract

“…The dipole–dipole interaction is maximized between Gd(III) and the hydrogens in the doped system leading to the attainment of high r 1 indicating the effectiveness of doping. [ 72,95,259–261 ] Higher concentrations of the metal result in high r 1 that can improve their detection sensitivity and Mn(II) and Gd(III) are thus considered as potential contrast agents. [ 260,262 ] Thus, doping by half‐filled metal ions of Mn(II) and Gd(III) renders MRI modality to CQDs by their magnetic properties that result in the relaxation of nuclear spins.…”

Section: Photophysical Properties Of Cqdsmentioning

confidence: 99%

Doping and Surface Modification of Carbon Quantum Dots for Enhanced Functionalities and Related Applications

John

Nair

2021

Part & Part Syst Charact

View full text Add to dashboard Cite

Carbon quantum dots (CQDs) are a unique class of 0D nanomaterials, featured by a graphitic core and shell layers saturated with hydrogen atoms and functional groups. CQDs are prepared through top‐down and bottom‐up strategies from natural and synthetic precursors. CQDs can be modified through chemical (e.g., surface functionalization/passivation, doping, etc.) and physical (e.g., core–shell architecture, composite material blending, etc.) strategies to control their properties. This review highlights the effect of such modifications on the photophysical properties of CQDs, such as photoluminescence (PL), absorbance, and relaxivity. The dependence of PL upon the size, orientation at the edges, surface and edge functionalization, doping, excitation wavelength, concentration, pH, aggregate formation, etc., are summarized along with the supporting theoretical evidence available in the literature. Also, this review outlines the recent advancements, and future prospective of optical (e.g., sensing, bioimaging, and fluorescent ink) and catalytic applications (e.g., photocatalysis and electrocatalysis) of CQDs enhanced through physical and chemical modifications of their structure and composition.

show abstract

Single-Atom Gadolinium Anchored on Graphene Quantum Dots as a Magnetic Resonance Signal Amplifier

Cited by 26 publications

References 68 publications

Nanoscale Contrast Agents for Magnetic Resonance Imaging: A Review

Nanoscale Contrast Agents for Magnetic Resonance Imaging: A Review

Multimodal Imaging and Phototherapy of Cancer and Bacterial Infection by Graphene and Related Nanocomposites

Doping and Surface Modification of Carbon Quantum Dots for Enhanced Functionalities and Related Applications

Contact Info

Product

Resources

About