Single-Atom Catalysis for Efficient Sonodynamic Therapy of Methicillin-Resistant Staphylococcus aureus-Infected Osteomyelitis

Abstract

Osteomyelitis, as a severe bone disease caused by bacterial infection, can result in lifelong disability or fatal sepsis. Considering that the infection is stubborn and deep-sited in bone tissue, in situ and rapid treatments for osteomyelitis remain a significant challenge. Herein, we prepare an ultrasound (US)-activated single-atom catalyst that consists of a Au nanorod (NRs)-actuated single-atom-doped porphyrin metal− organic framework (HNTM-Pt@Au) and red cell membrane (RBC), which can efficiently treat methicillin-resistant Staphylococcus aureus (MRSA)-infected osteomyelitis under US. Besides the outstanding performance in the field of photocatalysis, we find that single atoms (such as Pt, Au, Cu) also improve the sonocatalytic ability of the sonosensitizer. Due to the strong electron-trapping and oxygen adsorption capacity, the Pt single atom endows RBC-HNTM-Pt@Au with an excellent sonocatalytic activity. It shows an excellent antibacterial performance with an antibacterial efficiency of 99.9% toward MRSA under 15 min of US irradiation. Meanwhile, the RBC-HNTM-Pt@Au can be propelled directionally under US and thus dynamically neutralize the secreted toxins. The MRSA-infected osteomyelitis in rat tibia was successfully treated, which shows negligible bone loss, reduced inflammation response, and great biocompatibility. This work presents an efficient sonodynamic therapy for the treatment of deep tissue infections via a multifunctional single-atom catalyst.

Nanodot-doped peptide hydrogels for antibacterial phototherapy and wound healing

“…4C). 34 Therefore, although the GR hydrogel is more effective in killing E. coli cells, it can also effectively suppress the growth of S. aureus and cause cell lysis.…”

Emerging Single‐Atom Catalysts/Nanozymes for Catalytic Biomedical Applications

“…Furthermore, in 2021, Yu et al fabricated a multifunctional ultrasound-responsive Pt SAC (which consisted of red blood cell (RBC) membrane-coated Au nanorod-actuated porphyrin MOF that was doped with singleatom Pt, termed RBC-HNTM-Pt@Au) with sonocatalytic and dynamic detoxification abilities for healing methicillin-resistant S. aureus (MRSA)-infected osteomyelitis via SDT (Figure 12d). [22] The RBC membrane coating could endow HNTM-Pt@Au with toxin neutralization ability and improve the biocompatibility. Besides, Au nanorods were capable of facilitating the absorption of ultrasonic energy and enhancing the ultrasonic cavitation in the sonocatalytic system, therefore increasing the generation of 1 O 2 .…”

“…The SACs exhibited the ROS-scavenging ability as they could decompose the overproduced toxic H (d,e) Reproduced with permission. [22] Copyright 2021, American Chemical Society. [20] Copyright 2019, American Chemical Society.…”

“…Antibacterial application: Reproduced with permission. [22] Copyright 2021, American Chemical Society. Tumor therapy: Reproduced with permission.…”

“…Subsequently, the applications of SACs in catalytic biomedicine are further summarized (Scheme 1). [20][21][22][23][24] At the end of this review, we outline the future opportunities and challenges of SACs for biomedical applications, in hopes of facilitating researchers to enhance the catalytic activity and selectivity of SACs, improve their biophysicochemical properties, and broaden their biomedical applications.…”