Single and multi-functional coating strategies for enhancing the biocompatibility and tissue integration of blood-contacting medical implants

Badv, Maryam; Bayat, Fariba; Weitz, Jeffrey I.; Didar, Tohid F.

doi:10.1016/j.biomaterials.2020.120291

Cited by 93 publications

(93 citation statements)

References 266 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Coagulation is the serious problem met by current artificial blood vessels with smaller diameters than 6 mm. [56] Many ways have been tried including endothelialization, heparinized, and so on. [56,57] For the printed constructs facing the similar challenge, to resolve the coagulation issue and reduce the risk of a thrombosis, the inks and the connected tubes we used here are bioactive materials which could sustain blood coagulation in short periods of time.…”

Section: Discussionmentioning

confidence: 99%

3D Liver Tissue Model with Branched Vascular Networks by Multimaterial Bioprinting

Liu

Wang

Zhang

et al. 2021

Adv Healthcare Materials

View full text Add to dashboard Cite

Complicated vessels pervade almost all body tissues and influence the pathophysiology of the human body significantly. However, current fabrication strategies have limited success at multiscale vascular biofabrication. This study reports a methodology to fabricate soft vascularized tissue at centimeter scale using multimaterial bioprinting by a customized multistage-temperature-control printer. The printed constructs can be perfused via the branched endothelialized vasculatures to support the well-formed 3D capillary networks, which ensure cellular activities with sufficient nutrient supply and then mimic a mature and functional liver tissue in terms of synthesis of liver-specific proteins. Moreover, an inner and external pressure-bearing layer is printed to support the direct surgical anastomosis of the carotid artery to the jugular vein. In summary, a versatile platform to recapitulate the vasculature network is presented, in which case sustaining the optimal cellularization in engineered tissues is achievable.

show abstract

Section: Discussionmentioning

confidence: 99%

3D Liver Tissue Model with Branched Vascular Networks by Multimaterial Bioprinting

Liu

Wang

Zhang

et al. 2021

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Free radicals, which are thermodynamically unstable, quickly react with the polymer backbone itself or with other free-radical species present at the surface to form stable covalently bonded atoms or more complex groups. This is known as surface functionalization, which can be, from the medical application point of view, used for direct interaction with biological material [32] or used to improve adhesion of various types of bioactive coatings [33][34][35].…”

Section: Enhanced Surface Hydrophilicity and Cell Adhesionmentioning

confidence: 99%

Cold Plasma Systems and Their Application in Surface Treatments for Medicine

Tabarés

Junkar

2021

Molecules

View full text Add to dashboard Cite

In this paper, a review of cold plasma setups and the physical and chemical processes leading to the generation of active species is presented. The emphasis is given to the interaction of cold plasmas with materials used in medical applications, especially medical implants as well as live cells. An overview of the different kinds of plasmas and techniques used for generation of active species, which significantly alter the surface properties of biomaterials is presented. The elemental processes responsible for the observed changes in the physio-chemical properties of surfaces when exposed to plasma are described. Examples of ongoing research in the field are given to illustrate the state-of-the-art at the more conceptual level.

show abstract

“…It is a phospholipid-like polymer, mimicking the surface structure of the cellular membrane of red blood and other cells [ 141 , 160 ]. MPC coatings are generated either through physical adsorption or through covalent attachment [ 161 ]. It has been reported that surfaces with immobilized MPC show reduced protein adsorption, platelet adhesion, and complement activation [ 1 , 160 ].…”

Section: Design Of Blood-compatible Surfacesmentioning

confidence: 99%

Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review

et al. 2021

View full text Add to dashboard Cite

Hemocompatibility of biomaterials in contact with the blood of patients is a prerequisite for the short- and long-term applications of medical devices such as cardiovascular stents, artificial heart valves, ventricular assist devices, catheters, blood linings and extracorporeal devices such as artificial kidneys (hemodialysis), extracorporeal membrane oxygenation (ECMO) and cardiopulmonary bypass. Although lower blood compatibility of materials and devices can be handled with systemic anticoagulation, its side effects, such as an increased bleeding risk, make materials that have a better hemocompatibility highly desirable, particularly in long-term applications. This review provides a short overview on the basic mechanisms of blood coagulation including plasmatic coagulation and blood platelets, as well as the activation of the complement system. Furthermore, a survey on concepts for tailoring the blood response of biomaterials to improve the hemocompatibility of medical devices is given which covers different approaches that either inhibit interaction of material surfaces with blood components completely or control the response of the coagulation system, blood platelets and leukocytes.

show abstract

Single and multi-functional coating strategies for enhancing the biocompatibility and tissue integration of blood-contacting medical implants

Cited by 93 publications

References 266 publications

3D Liver Tissue Model with Branched Vascular Networks by Multimaterial Bioprinting

3D Liver Tissue Model with Branched Vascular Networks by Multimaterial Bioprinting

Cold Plasma Systems and Their Application in Surface Treatments for Medicine

Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review

Contact Info

Product

Resources

About