This article investigates the variegated urbanization of technology-based economies through the lenses of a comparative analysis looking at New York City and Rio de Janeiro. Over the last decade, the former has gained a reputation as a 'model tech city' at the global level, while the latter is an example of emerging 'start-up city'. Using a Marxist-Foucauldian approach, the article argues that, while technopoles in the 1980s and the 1990s arose from the late Keynesian state, the globally hegemonic phenomenon of start-up urbanism is illustrative of an increasingly decentralized neoliberal project of self-governing 'enterprise society', mobilizing ideas of community, cooperation and horizontality within a context of cognitive-communicative capitalism in which urban environments acquire renewed centrality. In doing so, the article underlines start-up urbanism's key contribution to the reinvention of the culture of global capitalism in times of perceived economic shrinkage worldwide and the central role played by major metropolitan centres in this respect.