Síndrome serotoninérgico: Presentación de cuatro casos y revisión de la literatura

Abstract

The serotonin syndrome is a clinical condition associated with serotonin agonists. Is due to an overstimulation of central and peripheral serotonin receptors that leads to mental, autonomic and neuromuscular changes. Usually the disorder resolves within the first 24 hours after the medications are discontinued, however some patients progress to a multiple organ failure and die. We describe four elderly patients that presented with the classic triad. They presented the symptoms in average at the third day after the initiation or variation of the treatment with serotonin reuptake inhibitors. All had a favorable response with the suspension of medications and, in three cases, with the treatment with chlorpromazine. We believe it is a potentially fatal but reversible condition, probably underdiagnosed that requires a high index of suspicion.

Management of severe arterial hypertension associated with serotonin syndrome: a case report analysis based on systematic review techniques

“…Of these, 49 cases reported severe arterial hypertension of at least 175 mmHg systolic and 22 commented on the antihypertensive treatment and outcome (Table 3). 9–29…”

Inibidores seletivos de recaptação de serotonina no tratamento da depressão: síndrome de descontinuação e/ou de dependência?

“…Ansiedade, depressão, perda de peso, disfunção sexual (Young et al, 2008). Casos como de hiponatremia presentes nas bulas como advertência e precauções, foi relato por Scalco (2002), em um estudo de enfermaria psiquiátrica de idosos que tiveram hiponatremia após o uso de ISRS ocorrendo em 25% dos casos.…”

El síndrome serotoninérgico

“…El antibiótico que se involucra en el SS, por su particular mecanismo, es el linezolid. El linezolid, un antibiótico tipo oxazolidinona, que a la vez es un inhibidor reversible de la MAO A y B, puede generar, en interacciones con un ISRS, un SS [34,35,36,37], por lo tanto debería evitarse el uso de linezolid junto a un ISRS. El linezolid también interacciona con otros serotoninérgicos como la meperidina [38] y la venlafaxina [39].…”