Síndrome neuroléptica maligna: relato de caso com recorrência associada ao uso de olanzapina

Hanel, Ricardó A.; Sandmann, Marcos C.; Kranich, Martina; Bittencourt, P. R. M.

doi:10.1590/s0004-282x1998000500022

Cited by 16 publications

(4 citation statements)

References 27 publications

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“…It is characterized by muscle rigidity and hyperthermia, and at least two of the following minor signs: diaphoresis, dysphagia, tremor, incontinence, altered mentation, mutism, tachycardia, elevated or labile blood pressure, leukocytosis and elevation of creatine phosphokinase. 1 Often, the rectal temperature is over 41° C. Muscle rigidity and increased heat production result in acidosis and rhabdomyolysis. The creatine kinase level is elevated in 92% of cases and leukocytosis is common.…”

Section: Discussionmentioning

confidence: 99%

“…Neuroleptic malignant syndrome is characterized by muscle rigidity, hyperthermia, diaphoresis, fluctuating consciousness and rhabdomyolysis. [1][2][3][4] Respiratory failure secondary to muscle rigidity, and aspiration and pulmonary embolism have been described. 5, 6 A case of acute respiratory distress syndrome associated with neuroleptic drug administration, with concomitant neuroleptic malignant syndrome, is reported.…”

Section: Introductionmentioning

confidence: 99%

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Neuroleptic-induced acute respiratory distress syndrome

2003

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A 41-year-old man presented right otalgia and peripheral facial paralysis. A computed tomography scan of the skull showed a hyperdense area, 2 cm in diameter, in the pathway of the anterior intercommunicating cerebral artery. Preoperative examination revealed: pH 7.4, PaCO2 40 torr, PaO2 80 torr (room air), Hb 13.8 g/dl, blood urea nitrogen 3.2 mmol/l, and creatinine 90 mmol/l. The chest x-ray was normal. The patient had not eaten during the 12-hour period prior to anesthesia induction. Intravenous halothane, fentanyl 0.5 mg and droperidol 25 mg were used for anesthesia. After the first six hours, the PaO2 was 65 torr (normal PaCO2) with FiO2 50% (PaO2/FiO2 130), and remained at this level until the end of the operation 4 hours later, maintaining PaCO2 at 35 torr. A thrombosed aneurysm was detected and resected, and the ends of the artery were closed with clips. No vasospasm was present. This case illustrates that neuroleptic drugs can cause neuroleptic malignant syndrome associated with acute respiratory distress syndrome. Neuroleptic malignant syndrome is a disease that is difficult to diagnose. Acute respiratory distress syndrome is another manifestation of neuroleptic malignant syndrome that has not been recognized in previous reports: it may be produced by neuroleptic drugs independent of the manifestation of neuroleptic malignant syndrome. Some considerations regarding the cause and effect relationship between acute respiratory distress syndrome and neuroleptic drugs are discussed. Intensive care unit physicians should consider the possibility that patients receiving neuroleptic drugs could develop respiratory failure in the absence of other factors that might explain the syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuroleptic-induced acute respiratory distress syndrome

2003

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“…Os antipsicóticos são amplamente prescritos para diversas patologias psiquiátricas, incluindo quadros depressivos e de mania, transtornos de personalidade, alguns sintomas de demência e para casos específicos de alteração comportamental 7 . Desse modo, o conhecimento por parte da equipe médica sobre a SNM possibilita um rápido reconhecimento dos sinais e sintomas, bem como imediato diagnóstico e intervenção, sendo decisivos para melhor prognóstico desses pacientes 8 .…”

Section: Introductionunclassified

Relato De Caso: Síndrome Neuroléptica Maligna

et al. 2021

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To report the case of a patient with bipolar affective disorder (BPD) in psychiatric care, who was diagnosed three times with Neuroleptic Malignant Syndrome by different antipsychotics(NMS).A 57-year-old female patient with previous diagnosis of BD was admitted to the hospital with fever, muscle stiffness, tremors, behavioral changes, lowering of consciousness level, increased CPK and leukocytosis, which were not clarified by another medical condition, then suspected of Neuroleptic MalignantSyndrome.The use of antipsychotics is essential for several psychiatric disorders, such as mania, personality disorders and dementia in general, and the onset of NMS is unpredictable. It is concluded that a depth knowledge of the disease is necessary for early diagnosis and treatment, which will result a better prognosis.

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“…Entretanto, apesar de apresentar efeitos colaterais autonômicos (sedação, hipotensão postural, etc.) menos proeminentes, ele apresenta maior possibilidade de desencadear reações extrapiramidais (distonia aguda, parkinsonismo medicamentoso, acatisia, síndrome neuroléptica maligna e discinesia tardia) do que os antipsicóticos de baixa potência (Bechelli, 2000), além de ser é considerado o agente causal mais freqüente da síndrome neuroléptica maligna (Hanel et al, 1998).…”

Section: Introductionunclassified

Avaliação de aspectos cognitivos em homens portadores de esquizofrenia em tratamento com haloperidol ou clozapina

Johann

Vaz

2006

J. bras. psiquiatr.

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OBJETIVO: Avaliar, sob o ponto de vista psicológico, aspectos cognitivos de pacientes portadores de esquizofrenia associados ao tipo de medicamento antipsicótico em uso. MÉTODOS: Participaram dois grupos: no grupo 1 os pacientes em tratamento com haloperidol (n = 14) e no 2 aqueles em tratamento com clozapina (n = 16). Ambos os grupos eram formados por indivíduos com esquizofrenia em tratamento psiquiátrico ambulatorial no Hospital de Clínicas de Porto Alegre (HCPA), cuja faixa etária variou entre 18 e 59 anos. Foram usados como instrumentos o Operational Checklist for Psychotic Illness (OPCRIT) para definição do diagnóstico de esquizofrenia e a técnica de Rorschach. Também se realizou a análise de variância (ANOVA) seguida do teste de Bonferroni, com nível de significância de p < 0,05 sobre os dados do teste de Rorschach. RESULTADOS: O grupo 1 apresentou F+ < 80%; FK < KF + K; FC < CF + C. O grupo 2 apresentou F+ > 80%; FK = KF + K; FC > CF + C. Ambos os grupos apresentaram escore de forma (sigmaF) na faixa clínica considerada normal. CONCLUSÃO: Os resultados do Rorschach permitem inferir que os pacientes medicados com clozapina apresentam indicativos de capacidade de produção e adaptação à tarefa, controle pelo uso da inteligência sobre impulsos e instintos, capacidade para suportar frustração e funcionamento do raciocínio lógico em melhores condições do que os pacientes medicados com haloperidol.

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Síndrome neuroléptica maligna: relato de caso com recorrência associada ao uso de olanzapina

Cited by 16 publications

References 27 publications

Neuroleptic-induced acute respiratory distress syndrome

Neuroleptic-induced acute respiratory distress syndrome

Relato De Caso: Síndrome Neuroléptica Maligna

Avaliação de aspectos cognitivos em homens portadores de esquizofrenia em tratamento com haloperidol ou clozapina

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