Síndrome metabólica em pacientes com esquizofrenia refratária: características sociodemográficas, clínicas e comportamentais

Abstract

RESUMOObjetivo: traçar o perfil sociodemográfico e clínico dos pacientes com esquizofrenia refratária que fazem uso do antipsicótico clozapina de acordo com a presença de síndrome metabólica. Método: Trata-se de um estudo epidemiológico de delineamento descritivo e transversal. A amostra final foi composta por 72 participantes que atenderam aos critérios de inclusão. Foram coletados dados sociodemográficos, clínicos, antropométricos e bioquímicos. Realizou-se análise descritiva dos dados. Resultados: Observou-se que a presença de síndrome metabólica em mulheres (58,8%) foi superior aos homens (41,2%). Os pacientes apresentaram percentuais mais elevados de alterações nos componentes da síndrome, principalmente glicemia e triglicérides. 65% dos pacientes fazem uso de quatro ou mais medicamentos e 47,1% dos indivíduos apresentaram sobrepeso e 38,2% obesidade. Conclusão: Sugere-se a construção de estratégias de prevenção primária das alterações metabólicas, bem como a monitoração continuada de suas questões clínicas, principalmente em relação aos componentes da síndrome. Descritores: Perfil de saúde; Características da população; Esquizofrenia; Clozapina; Síndrome x metabólica.ABSTRACT Objective: to trace the sociodemographic and clinical profile of patients with refractory schizophrenia that make use of antipsychotic clozapine according to the presence of metabolic syndrome. Method: This is an epidemiological study of descriptive and cross-sectional design. The sample consisted of 72 patients who met the inclusion criteria. Sociodemographic, clinical, anthropometric and biochemical data were collected. It was realized descriptive analysis of data. Results: It was observed that the presence of metabolic syndrome it was higher in women (58.8%) of than men (41.2%). Patients had higher percentages of changes in the components of the syndrome, especially glucose and triglycerides. 65% of patients make use of four or more drugs and 47.1% of subjects were overweight and 38.2% obese. Conclusion: it is suggested that the construction of primary prevention strategies of metabolic changes as well as continued monitoring of clinical issues, especially regarding the components of the syndrome. Descriptors: Health profile; Population characteristics; Schizophrenia; Clozapine; Metabolic syndrome x. RESUMEN Objetivo: trazar el perfil sociodemográfico y clínico de los pacientes con esquizofrenia refractaria que hacen uso de la clozapina antipsicótica de acuerdo con la presencia de síndrome metabólico. Método: Se trata de un estudio transversal epidemiológico. La muestra consistió en 72 pacientes que cumplían los criterios de inclusión. Se recogieron datos sociodemográficos, clínicos, antropométricos y bioquímicos. Un análisis descriptivo de los datos. Resultados: se observó que la presencia de síndrome metabólico en las mujeres (58,8%) fue mayor que en los hombres (41,2%). Los pacientes tenían mayores porcentajes de cambios en los componentes del síndrome, sobre todo glucosa y triglicéridos. 65% de los pacientes hacen uso de cuatro...

Prevalence of polymorphisms in the ANKK1, DRD2, DRD3 genes and metabolic syndrome in refractory schizophrenia

“…Metabolic disturbances are more prevalent in schizophrenic patients than in the general population and this may translate into an increased risk of chronic degenerative diseases and even mortality in this group 14 . According to Papanastasiou (2013), women tend to have increased rates of MS compared to men, a datum corroborated in the present study.…”

“…Routine follow-up on a regular basis and education on healthy lifestyle are necessary to minimize the risks of complications 2 - 15 . The hypotheses raised in this study suggest that the health care for refractory schizophrenic patients using clozapine must be comprehensive, and the planning of strategies aimed at minimizing the risk of metabolic alterations should be one of the main goals of the individual therapeutic plan for these patients 2 - 14 .…”

“…However, it is a very relevant investigation because it showed the components that can lead to MS. In addition, a better elucidation of these factors is important to avoid other disastrous complications in the health of these patients 14 .…”

Voice hearers’s appetite condition: a potential indicator for health care / Condição de apetite de ouvidores de vozes: um potencial indicador para o cuidado em saúde

“…2 It is known that people with psychiatric disorders have an additional risk of developing disorders and nutritional deficiencies, as they use several drugs that interact with nutrients, increase appetite and weight, modify the taste, furthermore, many live with chronic non-diseases, such as: diabetes, systemic arterial hypertension, and excess weight. 3 Food can influence not only the development but also the prevention, control, and treatment of psychiatric diseases.…”