Objective:to estimate the prevalence of TaqIA, -141C and rs6280 polymorphisms of the ANKK1, DRD2 and DRD3 genes and evaluate their association with the occurrence of metabolic syndrome in patients with refractory schizophrenia. Method:cross-sectional study conducted in the Extended Western Region of Minas Gerais, with refractory schizophrenic patients using the antipsychotic clozapine. Sociodemographic, clinical, anthropometric, biochemical and genetic data were collected. Univariate analysis of the data was performed. Results:seventy-two patients participated in the study and the occurrence of Metabolic Syndrome was observed in 47.2% of them. There was no association between Metabolic Syndrome and the studied polymorphisms. There was a statistically significant difference in the low HDL parameter with homozygous genotype for the C allele of the -141C polymorphism of the DRD2 gene. Conclusion:a high prevalence of MS was evidenced. The -141C polymorphism was associated with low HDL. Genetic analysis and identification of metabolic alterations in this group of patients can guide drug treatment and provide a better quality of life.
Objective: to present the profile of quality of life and symptoms of anxiety, depression and stress in university students in the healthcare area. Method: a descriptive study with a quantitative approach to data, carried out with university students in the healthcare field of three Federal Institutions of Higher Education in Minas Gerais. Variables such as sociodemographic, lifestyle, presence of depression symptoms, anxiety and stress, and quality of life (QoL) were measured. The QoL was assessed using the WHOQUOL-bref scale and symptoms of depression, anxiety and stress using the DASS-21 scale. A descriptive data analysis was performed. Results: 321 students participated in the study, mostly female (71.0%). More than 50% of the students had symptoms of depression, anxiety and stress, regardless of the level of severity, while severe/very severe symptoms were present in more than 20% of them, presenting a higher proportion in the nursing course. The psychological domain had the lowest overall QoL score (58.33), and the best was observed in the social relationships domain (66.67). Nursing students had the lowest scores while physical education students had the best scores in most domains. Medical students had the best score in the environment domain (68.75). Conclusion: Suggest the planning of policies and strategies that promote the physical and mental well-being of students, as well as screening and monitoring of most vulnerable ones, as well as those with mental health problems; such strategies can positively impact QoL.
Objective: To analyze the quality of life of people with refractory schizophrenia using clozapine, and its associated factors. Methods: A cross-sectional study, conducted in the extended western region of Minas Gerais, which included patients with refractory schizophrenia using the antipsychotic, clozapine. For the measurement of quality of life, the Quality of Life Scale was used, specific for patients with schizophrenia. Univariate and multivariate analyses were performed. Results: A total of 72 patients with a mean age of 42.9 years was part of the study. The overall score of the Quality of Life Scale indicated compromised quality of life, with a greater impairment in the social network domain (median = 2.36). The logistic regression analysis showed factors associated with a better quality of life. Conclusion: Low quality of life in patients with refractory schizophrenia was found. Physical activity, family income over three times the minimum wage, and having children were associated with a better quality of life. ResumoObjetivo: Analisar a qualidade de vida de pessoas com esquizofrenia refratária em uso de clozapina e seus fatores associados. Métodos: Estudo de delineamento transversal, realizado na Região Ampliada Oeste de Minas Gerais, que incluiu pacientes com esquizofrenia refratária em uso do antipsicótico clozapina. Para a mensuração da qualidade de vida, foi utilizada a escala Quality of Life Scale, específica para pacientes com esquizofrenia. Foram realizadas análise univariada e multivariada. Resultados: Participaram 72 pacientes, com média de idade de 42,9 anos. O escore global da Quality of Life Scale indicou qualidade de vida comprometida, com maior prejuízo no domínio rede social (mediana = 2,36). A análise de regressão logística apontou fatores associados a uma melhor qualidade de vida. Conclusão: Evidenciou-se uma baixa qualidade de vida dos pacientes com esquizofrenia refratária. Praticar atividade física, renda familiar acima de três salários mínimos e possuir filhos foram associados à melhor qualidade de vida.
RESUMOObjetivo: Estimar prevalência de síndrome metabólica (SM) e seus fatores associados em pacientes com esquizofrenia refratária em uso do antipsicótico clozapina. Método: Trata-se de um estudo descritivo e transversal, realizado na Região Ampliada Oeste do Estado de Minas Gerais (MG), em 2015, com uma amostra de 72 pacientes. Foram coletados dados sociodemográficos, clínicos, antropométricos e bioquímicos. Realizou-se análise descritiva, univariada e multivariada. Resultados: Observou-se prevalência de SM em 47,2% da amostra, com predomínio entre as mulheres (58,8%). Pacientes com SM apresentaram percentuais mais elevados de alterações, principalmente em relação à glicemia e triglicérides. O uso de quatro ou mais medicamentos e a presença de sobrepeso e obesidade estiveram associados à SM. Além disso, pacientes com a síndrome apresentaram um histórico de menos internações psiquiátricas, comparados àqueles que não a possui. Conclusão: A prevalência de SM encontrada nos pacientes com esquizofrenia refratária foi elevada e alarmante. A presença de sobrepeso e obesidade e o uso de 4 ou mais medicamentos podem estar associados com o desenvolvimento de SM neste grupo. Essa taxa pode representar um importante indicador de risco cardiovascular, sendo sugerida a construção de estratégias de prevenção primária das alterações metabólicas, bem como se indica que o paciente seja acompanhado periodicamente, principalmente em relação aos componentes da SM.
Pesquisa realizada com o objetivo de caracterizar o perfil sociodemográfico e clínico de pacientes acometidos por transtornos alimentares e o uso de álcool e outras drogas. Trata-se de uma pesquisa descritiva, desenvolvida com pacientes atendidos no período de julho/1997 a julho/2013 em um Centro de Atenção Psicossocial tipo III da região Centro-Oeste de Minas Gerais. A amostra foi composta por 780 pacientes e os principais resultados encontrados foram: maior proporção do sexo feminino (59%); faixa etária de 10 a 20 anos (49,9%), diagnósticos de anorexia nervosa (47,6%) e bulimia nervosa (21,8%) e a droga mais utilizada foi o álcool (42,8%). Esses dados apontam uma situação alarmante e de significativa importância epidemiológica, notadamente para a população local, e poderão fornecer subsídios para a proposição de ações relacionadas à prevenção e controle, principalmente no que tange ao grupo de mulheres com transtornos alimentares que fazem uso abusivo de drogas. PALAVRAS-CHAVE: Transtorno alimentar. Anorexia nervosa. Bulimia nervosa. Dependência química. Study performed with the aim of characterizing the socio-demographic and clinical profile of patients suffering from eating disorders and the use of alcohol and other drugs. This is a descriptive research, developed with patients treated between from July 1997 and July 2013 in a Psychosocial Care Center type III in the Midwest region of Minas Gerais.The sample comprised 780 patients and the main results were the greater proportion of females (59%); the age group 10-20 years (49.9%), the diagnosis of anorexia nervosa (47.6%) and bulimia nervosa (21.8%) and the most used drug was alcohol (42.8%). This data indicates an alarming situation and of significant epidemiological importance, notably for the local population, and may provide subsidies for proposing actions related to prevention and control, especially in regard to the group of women with anorexia with drug abuse.
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