Síndrome de Miller Fisher e neurite óptica: relato de caso

Carvalho, Aline Martins de; Galvão, Maria De Lourdes S.; Rocha, Maria Sheila Guimarães; Piccolo, Ana Claudia; Maia, Solyon C.

doi:10.1590/s0004-282x2000000600021

Cited by 10 publications

(9 citation statements)

References 7 publications

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“…To our knowledge, the present study is the largest trial demonstrating VEP pathologies in adult GBS patients. Previously reported VEP abnormalities in GBS patients are absent VEPs,28 P100 elongation,7,20,24,27,33,34 N145 latency elongation,5 and alterations in P100 morphology 25. P100 latencies differed significantly between the two sides in all of our patients with pathologic VEPs, suggesting that if it is present, optic-nerve or postchiasmal involvement is always asymmetric.…”

Section: Discussionsupporting

confidence: 50%

Visual Evoked Potentials in Guillain-Barré Syndrome

Güngör

Öztürk

et al. 2011

J Clin Neurol

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Background and PurposeGuillain-Barré syndrome (GBS) is an acute demyelinating polyneuropathy with various clinical features. Optic neuritis occurs in rare cases. In this study we determined the incidence and patterns of visual evoked potential (VEP) abnormality in GBS in association with ophthalmologic findings.MethodsThirty-two patients with a diagnosis of GBS were included in the study. The correlation between pathologic VEPs and categories of neurologic deficit and electrophysiological findings were examined statistically.ResultsThe patients ranged in age from 19 to 77 years. Five cases (16%) had abnormal VEPs. All five of these patients exhibited increased P100 latency differences between the two eyes. Other abnormalities were prolonged p100 latency, increased interocular amplitude difference, and distorted p100 configuration. Pathologic signs on ophthalmologic examination were observed in 80% of patients with abnormal VEPs. VEP abnormality was never present in pure axonal forms. There was no significant correlation between pathologic VEP and cerebrospinal fluid protein level or categories of neurologic deficits.ConclusionsInvolvement of the optic pathways is not a frequent finding in GBS. When present it is always asymmetric and generally accompanied with pathologic findings on ophthalmologic examination. VEPs may be abnormal in different clinical variants of GBS, and especially in demyelinating forms.

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Section: Discussionsupporting

confidence: 50%

Visual Evoked Potentials in Guillain-Barré Syndrome

Güngör

Öztürk

et al. 2011

J Clin Neurol

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“…Since its initial description there have been few studies that report a large sample of patients and describe the clinical characteristics of the Miller Fisher syndrome (MFS) in ample detail. There are also very few reports in the literature regarding the clinical manifestations of MFS in the Latin-American population [2, 3,20,21,22]. Our hospital is a tertiary neurological referral center, which takes care of 40% of the Mexican population, estimated at 103.3 million inhabitants.…”

Section: Introductionmentioning

confidence: 99%

Miller Fisher Syndrome: 10 Years’ Experience in a Third-Level Center

San-Juan

Martínez-Herrera²,

García³

et al. 2009

Eur Neurol

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Introduction: There are few studies regarding the clinical characteristics of Miller Fisher syndrome (MFS) in the Latin-American population. Methods: A retrospective analysis was made of the clinical characteristics, neurophysiology, treatment and prognosis of MFS patients between 1995 and 2005. Results: Nineteen MFS cases were documented, 12 of which did not receive immunosuppressive therapy. In both groups, the mean age was 36 years, 84% were male; onset in spring and fall was also predominant (73%), and antecedents of respiratory disease were found (79%). The mean duration of infectious symptoms was 7 days (1–11 days), and the mean interval between the onset of the infection and neurological symptoms was 7 days (1–30 days). The principal sign of onset was diplopia (63%). The mean delay between the onset of neurological symptoms and the beginning of recovery from ataxia, ophthalmoplegia and areflexia was 10 (1–30 days), 11 (1–30 days) and 14 (4–45 days) days, respectively, and the mean delay of the disappearance of ataxia, ophthalmoplegia and areflexia was 35 (10–121 days), 93 (18–244 days) and 64 (10–650 days) days, respectively. There was no significant difference between the group that received immunosuppression and the one that did not. Discussion: The natural course of MSF is characterized by excellent recovery; there were no differences between the two groups.

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“…Regarding the involvement of the cranial nerves, we should bear in mind that the oculomotor nerve fibers are rich in GQ1b antigen. That might explain the involvement of these fibers in Miller Fisher syndrome and the observed high frequency of ophthalmoplegia with serum positivity to this antigen in patients with Miller Fisher syndrome 12…”

Section: Case Reportmentioning

confidence: 95%

“…Controversies regarding this issue persist in the literature reviewed, because immunohistochemical studies have shown that anti-GQ1b antibodies, which are involved in this entity, stain sensory neurons in the dorsal root ganglion and a population of cerebellar neurons. Therefore, it is possible that the two mechanisms are associated 12…”

Section: Case Reportmentioning

confidence: 99%

“…In addition to the classic triad of ataxia, ophthalmoplegia, and areflexia, the clinical presentation of Miller Fisher syndrome includes the involvement of other cranial nerves, with the facial nerve being the most commonly affected nerve, as observed in this case. Chief among spared cranial nerves is the optic nerve, which is rarely affected 12…”

Section: Case Reportmentioning

confidence: 99%

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Miller Fisher syndrome: a rare variant of Guillain-Barré syndrome

Bandeira¹,

Palaoro²,

Degenszajn³

2012

ACR

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This report describes the case of a 39-year-old male patient who presented to the emergency room with complaints of impaired balance, diplopia, and nasal voice. The patient had a history of upper respiratory tract infection. The initial physical examination revealed ataxia, ophthalmoplegia, and areflexia, which are consistent with the classic triad of Miller Fisher syndrome, considered a benign variant of Guillain-Barré syndrome. The patient developed peripheral facial paralysis during hospitalization. He underwent a treatment with immunoglobulin for five days, resulting in near complete resolution of the ataxia. However, the ophthalmoplegia and areflexia persisted. He was discharged to outpatient follow-up.

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Síndrome de Miller Fisher e neurite óptica: relato de caso

Cited by 10 publications

References 7 publications

Visual Evoked Potentials in Guillain-Barré Syndrome

Visual Evoked Potentials in Guillain-Barré Syndrome

Miller Fisher Syndrome: 10 Years’ Experience in a Third-Level Center

Miller Fisher syndrome: a rare variant of Guillain-Barré syndrome

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