“…A polymicrobial flora is usually found, including gram-ne gative bacteria (e.g., Escherichia coli, Proteus mi rabilis, Klebsiella sp., Pseudomonas, Bacteroides sp., Aci netobac ter sp. ), gram-positive bacteria (e.g., staphylococci, streptococci, enterococci, and Clostridium), and fungi [12][13][14][15] (Table 1). Contemporary case series indicate that Fournier's syndrome usually affects patients between the third and sixth decades of life with comorbidities such as debilitating conditions (e.g., malnutrition and sepsis); immunosuppression (e.g., diabetes mellitus, chronic alcoholism, underlying malignancy, AIDS, measles, chemotherapy, and leukemia); colorectal and urogenital diseases; postoperative complications (associated with urologic instrumentation use, herniorrhaphy, hemorrhoidectomy, orchiectomy, and prostatectomy), intravenous drug use; and trauma (e.g., local, mechanical, technical, and chemical) including bites, scratches, and vaginal and anal intercourse [15][16][17] .…”