Simvastatin improves morphological and functional recovery of sciatic nerve injury in Wistar rats

Background: Olfactory ensheathing cells (OECs) are highly specialized glial cells that guide olfactory receptor axons from nasal mucosa to olfactory bulb. Olfactory ensheathing cells (OECs) are attractive candidates for transplantation-mediated repair of injured nervous system owing to their neuroregenerative properties. Aim of the work: To evaluate the neuroregenerative role of OECs in a model of sciatic nerve crush injury in rats. Materials and Methods: OECs were isolated from the olfactory mucosa of 15 male albino rats (100 gm). Thirty adult female albino rats (200-250 gm) were used and divided into three groups of 10 rats each. Group I (control group) underwent sham operation. Group II underwent crush injury of sciatic nerve. Group III underwent sciatic nerve crush injury then injected with single dose of 3×104 OECs at the lesion site. All rats were sacrificed after 3 weeks from the onset of the experiment. Results: Histological examination of sciatic nerves of group II rats showed discontinuity of nerve fibers with vacuolated axoplasm. OECs transplantation in group III revealed restoration of the normal histological architecture of the sciatic nerves. A significant decrease in the diameter of myelinated nerve fibers and myelin sheath thickness was recorded in group II compared to the control group. However, group III revealed a significant increase in the previous parameters compared to group II. Conclusions: Olfactory ensheathing cells (OECs) have neuroregenerative properties which might represent a new vision in human cell based therapy.

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“…Myelin sheaths were irregular, splitted, and disrupted. These results were in accordance with what were mentioned by Xavier et al 2012 [30] .…”

Section: Discussionsupporting

confidence: 94%

Neuroregenerative role of transplanted olfactory ensheathing cells in a model of sciatic nerve crush injury in rats: Histological study

Gawad

Ali

Fikry

2017

Egyptian Journal of Histology

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“…Statins have also been explored for their beneficial effects in attenuation of neuropathic pain in various animal models (Shi et al, 2011;Xavier et al, 2012). Treatment with statins attenuated peripheral and central pain without altering the serum cholesterol levels in animal models of neuropathic pain like mouse partial sciatic nerve ligation and rat trigeminal neuralgia model (Shi et al, 2011), streptozotocin (STZ)-induced diabetic neuropathy (Cameron et al, 2003), and sciatic nerve crush injury model in Wistar rats (Xavier et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Treatment with statins attenuated peripheral and central pain without altering the serum cholesterol levels in animal models of neuropathic pain like mouse partial sciatic nerve ligation and rat trigeminal neuralgia model (Shi et al, 2011), streptozotocin (STZ)-induced diabetic neuropathy (Cameron et al, 2003), and sciatic nerve crush injury model in Wistar rats (Xavier et al, 2012). However, the role of statins in vincristine-induced neuropathic pain is still not explored.…”

Section: Introductionmentioning

confidence: 99%

Dose-related neuropathic and anti-neuropathic effects of simvastatin in vincristine-induced neuropathic pain in rats

Bhalla

Singh

Jaggi

2015

Food and Chemical Toxicology

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“…Immune activation (i.e., inflammation) and the subsequent release of immune mediators into the peripheral nervous system play a critical role during nerve degeneration and regeneration. Various peripheral immune cells, including mast cells, macrophages, and lymphocytes, reside in peripheral nerves and/or are recruited to sites of peripheral nerve injury [55][56][57].…”

Section: Discussionmentioning

confidence: 99%

Molecular Changes at the Post-Synapse and Improved Motor Function Suggest Accelerated Recovery with SARM Treatment in an Androgen-Depleted Animal Model of Nerve Injury

Bryant¹

2017

J Musculoskelet Disord Treat

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Simvastatin improves morphological and functional recovery of sciatic nerve injury in Wistar rats

Cited by 47 publications

References 50 publications

Neuroregenerative role of transplanted olfactory ensheathing cells in a model of sciatic nerve crush injury in rats: Histological study

Neuroregenerative role of transplanted olfactory ensheathing cells in a model of sciatic nerve crush injury in rats: Histological study

Dose-related neuropathic and anti-neuropathic effects of simvastatin in vincristine-induced neuropathic pain in rats

Molecular Changes at the Post-Synapse and Improved Motor Function Suggest Accelerated Recovery with SARM Treatment in an Androgen-Depleted Animal Model of Nerve Injury

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