Simvastatin effects on dental socket quality: A comparative study

Sezavar, Mehdi; Bohlouli, B; Farhadi, Sareh; Tabatabaee, Shiva; Latifi, Reza

doi:10.4103/ccd.ccd_719_17

Cited by 10 publications

(2 citation statements)

References 24 publications

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“…One of these trials reported a higher percentage of vital, amorphous and trabecular bone in the simvastatin group after 2 months, though it should be noted that the differences were not statistically significant [68].…”

Section: The Effect Of Statins On Alveolar Socket Preservation Follow...mentioning

confidence: 98%

“…Thirteen studies investigated the effectiveness of statins on alveolar bone. Five studies evaluated alveolar bone loss following tooth extractions [66][67][68][69][70], while other studies were designed to investigate inflammatory periodontitis-mediated alveolar bone loss [71][72][73][74][75][76][77][78].…”

Section: Effects Of Statins On Alveolar Bone Loss Due To Either Extra...mentioning

confidence: 99%

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The effects of statins on dental and oral health: a review of preclinical and clinical studies

et al. 2020

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The statin family of drugs are safe and effective therapeutic agents for the treatment of arteriosclerotic cardiovascular disease (CVD). Due to a wide range of health benefits in addition to their cholesterol lowering properties, statins have recently attracted significant attention as a new treatment strategy for several conditions, which are not directly related to normalizing a lipid profile and preventing CVD. Statins exert a variety of beneficial effects on different aspects of oral health, which includes their positive effects on bone metabolism, their anti-inflammatory and antioxidant properties, and their potential effects on epithelization and wound healing. Additionally, they possess antimicrobial, antiviral, and fungicidal properties, which makes this class of drugs attractive to the field of periodontal diseases and oral and dental health. However, to the best of our knowledge, there has been no comprehensive study to date, which has investigated the effects of statin drugs on different aspects of dental and oral health. Therefore, the primary objective of this paper was to review the effect of statins on dental and oral health. Results of our extensive review have indicated that statins possess remarkable and promising effects on several aspects of dental and oral health including chronic periodontitis, alveolar bone loss due to either extraction or chronic periodontitis, osseointegration of implants, dental pulp cells, orthodontic tooth movement, and orthodontic relapse, tissue healing (wound/bone healing), salivary gland function, and finally, anti-cancer effects. Hence, statins can be considered as novel, safe, inexpensive, and widely-accessible therapeutic agents to improve different aspects of dental and oral health.

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Section: The Effect Of Statins On Alveolar Socket Preservation Follow...mentioning

confidence: 98%

Section: Effects Of Statins On Alveolar Bone Loss Due To Either Extra...mentioning

confidence: 99%

The effects of statins on dental and oral health: a review of preclinical and clinical studies

et al. 2020

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Tomographic evaluation of the effect of simvastatin topical use on alveolar bone microarchitecture, pain and swelling after mandibular third molar extraction: a randomized controlled trial

et al. 2022

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Effect of simvastatin topical use on alveolar bone after tooth extraction: a scoping review

Diniz,

Dourado,

Barbirato

et al. 2024

Clin Oral Invest

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Simvastatin effects on dental socket quality: A comparative study

Cited by 10 publications

References 24 publications

The effects of statins on dental and oral health: a review of preclinical and clinical studies

The effects of statins on dental and oral health: a review of preclinical and clinical studies

Tomographic evaluation of the effect of simvastatin topical use on alveolar bone microarchitecture, pain and swelling after mandibular third molar extraction: a randomized controlled trial

Effect of simvastatin topical use on alveolar bone after tooth extraction: a scoping review

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