Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease

The Implications of the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression Trial: A Return to First Principles

“…The combination of Simvastatin and niacin used in secondary prevention patients in the high-density lipoprotein (HDL)-Atherosclerosis Treatment Study (HATS) resulted in an 89% reduction in cardiovascular events; however, the comparison group received a placebo rather than a statin as solo therapy. 7 While these data with niacin are encouraging, they do not demonstrate an incremental benefit for niacin.…”

Review of non-surgical treatment options for Peyronie's Disease

“…To date, no placebo-controlled trials using vitamin E have demonstrated any clinical benefit in the treatment of PD, and there is some evidence that vitamin E may also increase the risk of cerebrovascular events. 36 Procarbazine Procarbazine is an oral alkylating agent primarily used as a component of chemotherapy regimens for Hodgkin's lymphoma, as well as primary CNS lymphoma and high-grade gliomas. 37 Procarbazine is a known cytotoxic agent with significant side-effect profile including hepatotoxicity, myelosuppression, central nervous system effects and gastrointestinal disturbances.…”

Cholesterol Goals: Moving from Numbers to Treatment

“…20 The NHLBI-sponsored AIM-HIGH trial is currently addressing this issue in 3,300 patients with CHD and the metabolic syndrome while the Heart Protection Study 2 Treatment of HDL to Reduce the Incidence of Vascular Events (HPS-THRIVE) is addressing combined niacin and statin therapy. Additionally, omega-3 treatment lowers both triglycerides and cardiovascular events in large primary and secondary prevention trials.…”