Simultaneously electrochemical detection of microRNAs based on multifunctional magnetic nanoparticles probe coupling with hybridization chain reaction

Yuan, Ye; Wu, Yidi; Chi, Baozhu; Wen, Shaohua; Liang, Ru‐Ping; Qiu, Jian‐Ding

doi:10.1016/j.bios.2017.06.022

Cited by 97 publications

(35 citation statements)

References 43 publications

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“…In order to identify the miRNAs relevant to a pathological condition, such II/R, it is important to find the miRNAs that are differentially expressed in biological samples taken from that condition. An effective method of such analysis is the microarrays assay, a high-throughput screening method, has been widely used for investigating drug targets and mechanisms of diseases Yuan et al, 2017). Thus, the aim of the present work was to find the differentially expressed miRNAs associated with II/R injury by microarrays assay and then to investigate the molecular mechanisms and drug targets for the prevention and treatment of II/R injury.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‐351‐5p aggravates intestinal ischaemia/reperfusion injury through the targeting of MAPK13 and Sirtuin‐6

Tao

Han

et al. 2018

British J Pharmacology

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Section: Introductionmentioning

confidence: 99%

MicroRNA‐351‐5p aggravates intestinal ischaemia/reperfusion injury through the targeting of MAPK13 and Sirtuin‐6

Tao

Han

et al. 2018

British J Pharmacology

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“…In the presence of miRNAs, the hybridization chain reaction was performed, and then the DNA1/Fe 3 O 4 NPs/Thi and DNA2/Fe 3 O 4 NPs/Fc were captured by the formed dsDNA, which generate a large number of magnetic nanoprobes attached to the surface. A magnified response of currents is obtained with good stability for 4 weeks and was applied for the diagnosis of miRNA in human breast cancer cells [72].…”

Section: Redox Molecules Linker To Nanocarriersmentioning

confidence: 99%

Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons

et al. 2020

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Cancer is the second most fatal disease in the world and an early diagnosis is important for a successful treatment. Thus, it is necessary to develop fast, sensitive, simple, and inexpensive analytical tools for cancer biomarker detection. MicroRNA (miRNA) is an RNA cancer biomarker where the expression level in body fluid is strongly correlated to cancer. Various biosensors involving the detection of miRNA for cancer diagnosis were developed. The present review offers a comprehensive overview of the recent developments in electrochemical biosensor for miRNA cancer marker detection from 2015 to 2020. The review focuses on the approaches to direct miRNA detection based on the electrochemical signal. It includes a RedOx-labeled probe with different designs, RedOx DNA-intercalating agents, various kinds of RedOx catalysts used to produce a signal response, and finally a free RedOx indicator. Furthermore, the advantages and drawbacks of these approaches are highlighted.

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“…Yuan et al [45] reported a biosensor for the simultaneous detection of pancreatic cancer biomarkers, miRNA-141 and miRNA-21, by taking advantage of the use of Fe3O4-NPs modified with two different redox markers, thionine (Thi) and ferrocene carboxaldehyde (Fc), and target-triggered HCR. In the presence of the corresponding miRNAs, the thiol-modified hairpin capture probes (HCP1 and HCP2) immobilized at Au, hybridize with miRNA-141 and miRNA-21, leading to the conformational change of these probes that trigger HCR and produce the capture of the signaling DNAs modified with the redox markers.…”

Section: Hybridization Chain Reaction (Hcr) Is An Excellent Amplification Techniquementioning

confidence: 99%

New trends in the development of electrochemical biosensors for the quantification of microRNAs

Mujica

Gallay

Perrachione

et al. 2020

Journal of Pharmaceutical and Biomedical Analysis

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Simultaneously electrochemical detection of microRNAs based on multifunctional magnetic nanoparticles probe coupling with hybridization chain reaction

Cited by 97 publications

References 43 publications

MicroRNA‐351‐5p aggravates intestinal ischaemia/reperfusion injury through the targeting of MAPK13 and Sirtuin‐6

MicroRNA‐351‐5p aggravates intestinal ischaemia/reperfusion injury through the targeting of MAPK13 and Sirtuin‐6

Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons

New trends in the development of electrochemical biosensors for the quantification of microRNAs

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