Simultaneous Tetanus Immunization and Reinforcement of Diphtheria Immunity in Adults, With Special Reference to the Interference Phenomenon

Scheibel, I.; Tulinius, S

doi:10.1111/j.1699-0463.1961.tb03199.x

Cited by 4 publications

(1 citation statement)

References 5 publications

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“…Following revaccination with 6 Lf tetanus toxoid, everybody with documentation for complete primary vaccination attained protective antibody levels, also when tetanus toxoid was administered combined with diphtheria toxoid. The slight antagonistic effect observed in the present study is in agreement with observations in relation to primary vaccination (2,10) and is considered to be of no practical importance.…”

Section: Discussionsupporting

confidence: 92%

Revaccination of Adults Against Diphtheria Ii: Combined Diphtheria and Tetanus Revaccination With Different Doses of Diphtheria Toxoid 20 Years After Primary Vaccination

Simonsen

Klærke

Klaerke

et al. 1986

Acta Pathologica Microbiologica Scandinavica Series C: Immunolo

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Revaccination of adults against diphtheria 11: Combined diphtheria and tetanus revaccination with different doses of diphtheria toxoid 20 years after primary vaccination. Acta path. microbiol. immunol. scand. Sect. C, 94: 219-225, 1986. Immunity following diphtheria vaccination in childhood is temporary, and recent outbreaks of diphtheria in adult populations evoked interest in the effect of and side-reactions to revaccination of adults. 237 military recruits were randomly allocated to revaccination with 6 Lf tetanus toxoid or 6 Lf tetanus toxoid combined with 2 Lf or 5 Lf diphtheria toxoid. Side-reactions were recorded one week later, and antitoxin response was assessed after 4 weeks. Protective serum diphtheria antitoxin levels were attained by all subjects receiving diphtheria toxoid containing vaccines. Antibody response was related to dose, indicating a safer long-term protection by revaccination with 5 Lf diphtheria toxoid. All vaccinees, except one without documentation for primary vaccination, attained high tetanus antitoxin levels. Interference phenomenona between toxoids were insignificant. Mild local reactions were reported by 22% of the vaccinees. More pronounced local reactions were experienced by 5% and systemic reactions by 3%, independent of vaccine. No serious reactions were observed. Reactions were significantly related to tetanus antitoxin response only. It was concluded that combined revaccination of adults, primary vaccinated around 20 years previously, may be performed without immune assessments.

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Section: Discussionsupporting

confidence: 92%