Simultaneous spectrophotometric estimation of rabeprazole sodium and itopride hydrochloride in capsule formulations

A study of selective spectrophotometric methods for simultaneous determination of Itopride hydrochloride and Rabeprazole sodium binary mixture: Resolving sever overlapping spectra

“…Besides, the criteria of the dual wavelength method for choosing the two wavelengths so that; one component showed different absorbance at the two selected wavelengths while the other component shows same absorbance at these wavelengths as upon subtraction it will be cancelled, makes the proposed ratio difference method simpler, more precise and more reliable as the ratio spectrum of the interfering component will show the same amplitudes (constant). The whole analysis is carried out using distilled water as solvent which ensures that the methods are environmentally safe compared to other reported methods [35,36,[38][39][40][41]. Generally, the suggested methods have minimum requirements compared to the previously reported spectrophotometric ones; it is not conditional to have isoabsorptive point, extension of one component than the other or zero crossing [33][34][35][36][37], which make the proposed methods more widely applied for the analysis of the cited drugs or other binary mixtures having sever overlapping spectra.…”

“…The whole analysis is carried out using distilled water as solvent which ensures that the methods are environmentally safe compared to other reported methods [35,36,[38][39][40][41]. Generally, the suggested methods have minimum requirements compared to the previously reported spectrophotometric ones; it is not conditional to have isoabsorptive point, extension of one component than the other or zero crossing [33][34][35][36][37], which make the proposed methods more widely applied for the analysis of the cited drugs or other binary mixtures having sever overlapping spectra.…”

“…For IT and RB determination in their binary mixture, few methods were reported from which are; derivative, derivative ratio, dual wavelength and Q-value spectrophotometric methods [33][34][35][36][37], HPTLC method [38] and reversed phase HPLC methods were also reported [35,[39][40][41].…”

“…Besides, no organic or hazardous solvents were used during the whole analysis which made the suggested methods environment friendly. With the advantages of minimal data processing and least requirements, the suggested methods are also of wider range of applications over the previously mentioned spectrophotometric ones [33][34][35][36][37] and of lower cost and more environment safe compared to chromatographic methods [35,[38][39][40][41].…”

Estimation of Rabeprazole Sodium and Itopride Hydrochloride in Tablet Dosage Form Using Reverse Phase High Performance Liquid Chromatography

“…The literature survey revealed that several methods have been reported for the individual estimation of rabeprazole sodium and itopride hydrochloride and in combination with other drugs by UV [3][4][5][6][7] , HPLC [8][9][10][11][12][13][14][15][16][17][18] and HPTLC [19][20][21][22] . However there is no method reported for the simultaneous analysis of the same combination by HPLC.…”