Simultaneous Spectrophotometric Determination of Valsartan and Ezetimibe in Pharmaceuticals

Abstract

were, 99.39 ± 0.53 and 98.17 ± 0.91 %, respectively, for the commercial formulation, and 99.41 ± 0.48 and 98.16± 0.89 %, respectively,

Stability-Indicating HPLC Method for the Simultaneous Determination of Valsartan and Ezetimibe in Pharmaceuticals

“…Additionally, the literature survey on EZE reveals spectrometric method [9][10][11][12] and chromatographic method [13][14][15] for the determination of ezetimibe individually or in combined dosage forms. Simultaneous spectrophotometric determination of valsartan and ezetimibe in pharmaceuticals has been reported [16]. Though a spectrophotometric method is less time consuming, it is inadequate in identification and separation of the potential impurities formed during its storage; hence a stability indicating HPLC method is essential.…”

“…The combined tablet formulation of valsartan and ezetimibe was prepared [16] and subjected to a stability studies in 3 different conditions namely 25 °C and 60 %RH, 30 °C and 65 %RH and 40 °C and 75 %RH as per the International Conference on harmonization (ICH) guidelines. The samples were drawn at periodic interval (1, 2, 3, 4.5 and 6 months) and the critical parameters like assay and release were ascertained.…”

Aqueous Solution‐Processable, Flexible Thin‐Film Transistors Based on Crosslinked Chitosan Dielectric Thin Films

“…This is due to the formation of Cr-CS. The yellowish color change occurred because of the formation of a Schiff base [9] (NCH(CH 2 ) 3 HCN) due to the reaction between the glutaraldehyde and CS, as shown in Figure 2.…”

1-(3-Bromopropyl)indoline-2,3-dione

“…Isatin (1H-indole-2,3-dione) derivatives possess diverse activities such as antibacterial, antifungal, antiviral, anti-HIV, anti-mycobacterial, anticancer, anti-inflammatory and anticonvulsant activities (Bhrigu et al 2010;Malhotra et al 2011;Ramachandran, 2011;Smitha et al 2008).…”