Simultaneous spectrophotometric determination of diuretics by using multivariate calibration methods

Luis, M Luz; Fraga, Jose María; Jiménez, Francisco Jiménez; Jiménez, Ana I.; Arias, J. J.

doi:10.1016/s0039-9140(00)00538-5

Cited by 24 publications

(4 citation statements)

References 14 publications

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“…On the other hand, the literature reports many analytical methods for the quantitative determination of hydrochlorothiazide individually or in their combination with other drugs, including, have been in pharmaceutical formulations, there methods use high performance liquid chromatography (HPLC) (4-10), polarography (11), capillary zone electrophoresis (12), and spectrophotometry (13)(14)(15)(16)(17)(18)(19)(20)(21). Derivative spectrophotometry offers greater selectivity than does normal spectrophotometry in the simultaneous determination of two or more compounds without previous chemical separation.…”

Section: Reprintsmentioning

confidence: 99%

Spectrophotometric Analysis of Valsartan and Hydrochlorothiazide

Erk

2002

Analytical Letters

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Two new methods for the simultaneous determination of valsartan and hydrochlorothiazide in pharmaceutical dosage forms have been developed. The first method, based on compensation technique is presented for the derivative spectrophotometric determination of binary mixtures with overlapping spectra. By using ratios of the derivative maxima or the derivative minimum, the exact compensation of either component in the mixture can be achieved, followed by its determination. The second method, differential derivative spectrophotometry, comprised of measurement of the difference absorptivities derivatized in the first order (ÁD 1 ) of a tablet extract in 0.1 N NaOH relative to that of an equimolar solution in methanol at wavelengths of 227.8 and 276.5 nm, respectively. Neither sample pre-treatment nor separation were required. These methods showed good linearity, precision, and reproducibility. The results obtained were compared with the results of reversed phase HPLC. It was found that 283 ORDER REPRINTS the difference was not statistically important between these methods. The proposed methods were accurate, sensitive, precise, reproducible and could be applied directly and easily to the pharmaceutical preparations.

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Section: Reprintsmentioning

confidence: 99%

Spectrophotometric Analysis of Valsartan and Hydrochlorothiazide

Erk

2002

Analytical Letters

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“…17,18 Many of which are not sufficiently sensitive [10][11][12][13][14]17,18 and/or are time consuming Vol. 20, No.…”

Section: Introductionmentioning

confidence: 99%

Ferrocenedicarboxylic acid modified carbon paste electrode: a sensor for electrocatalytic determination of hydrochlorothiazide

Karimi-Maleh¹,

Ensafi²,

Ensafi³

2009

J. Braz. Chem. Soc.

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A oxidação eletrolítica de hidroclorotiazida foi estudada usando-se eletrodo de pasta de carbono modificado com ácido ferrocenodicarboxílico. Voltametria cíclica e cronoamperometria foram usadas para investigar a possibilidade de aplicação do ácido ferrocenodicarboxílico como mediador na oxidação eletrocatalítica de hidroclorotiazida em solução aquosa. A oxidação de hidroclorotiazida ocorre em um potencial, aproximadamente, 300 mV menos positivo do que com o eletrodo de pasta de carbono não modificado, em pH 9,0. A constante de velocidade da reação catalítica, k h , foi calculada (3,38 × 10 2 cm 3 mol -1 s -1) usando-se cronoamperometria. Em condições ótimas, a corrente de pico da oxidação eletrocatalítica da hidroclorotiazida mostrou dois intervalos dinâmicos lineares com limite de detecção de 0,037 μmol L -1 de hidroclorotiazida. Os intervalos de calibração lineares ocorreram entre 0,08-5,8 μmol L -1 e 5,8-500,0 μmol L -1 de hidroclorotiazida, usando-se voltametria de onda quadrada. Finalmente, o método proposto foi também examinado quanto à seletividade, simplicidade e precisão na determinação de hidroclorotiazida em amostras reais como droga e urina.The electrocatalytic oxidation of hydrochlorothiazide has been studied by ferrocenedicarboxylic acid modified carbon paste electrode. Cyclic voltammetry and chronoamperometry were used to investigate the suitability of ferrocenedicarboxylic acid as a mediator for the electrocatalytic oxidation of hydrochlorothiazide in aqueous solution. The oxidation of hydrochlorothiazide occurs at a potential about 300 mV less positive than with the unmodified carbon paste electrode at pH 9.0. The catalytic reaction rate constant, k h was calculated (3.38 × 10 2 cm 3 mol -1 s -1 ) using chronoamperometry. Under the optimized conditions, the electrocatalytic oxidation peak current of hydrochlorothiazide showed two linear dynamic ranges with a detection limit of 0.037 μmol L -1 hydrochlorothiazide. The linear calibration ranges were between 0.08-5.8 μmol L -1 and 5.8-500.0 μmol L -1 hydrochlorothiazide using square wave voltammetric method. Finally, the proposed method was also examined as a selective, simple and precise electrochemical sensor for the determination of hydrochlorothiazide in real samples such as drug and urine.Keywords: ferrocenedicarboxylic acid, hydrochlorothiazide, electrocatalysis, square wave voltammetry IntroductionHydrochlorothiazide (HCTZ) (6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide) has gained attention because it is a benzothiazide diuretic that acts directly on the kidney by increasing the excretion of sodium chloride and water and, to a lesser extent, that of potassium ions. HCTZ is an antihypertensive substance and improves the action of other hypotensive substances, allowing a decrease in the dose of those below the level where these substances present secondary effects. Novello and Sprague observed the diuretic effect of thiazides with chlorothiazide in 1957.1 HCTZ is well absorbed, is shortly bound to plasma proteins, and ma...

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“…It is useful in spectral analyses because the simultaneous inclusion of multiple spectral intensities can greatly improve the precision and applicability of quantitative spectral analysis of multicomponent mixtures that can not be resolved by conventional spectrometry. In recent years multivariate calibration has become an important tool in resolution of mixtures of components in many different fields including biomedical 20,21 environmental 22,23 and drug analysis 24,25 . This paper describes an analytical methodology for simultaneous determination of Sulfamethoxazole and Trimethoprim using spectrophotometric method with preprocessing by direct orthogonal signal correction (DOSC).…”

Section: Introductionmentioning

confidence: 99%

Direct Orthogonal Signal Correction-Partial Least Squares for Simultaneous Spectrophotometric Determination of Sulfamethoxazole and Trimethoprim in Pharmaceutical Formulation and Synthetic Samples

Goodarzi

Shahbazikhah

Sohrabi

et al. 2009

J. Chil. Chem. Soc.

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This work describes a very simple, novel and selective spectrophotmetric method for simultaneous determination of sulfamethoxazole and trimethoprim in pharmaceutical preparation and synthetics samples using direct orthogonal signal correction-partial least squares (DOSC-PLS). The all factors affecting on the sensitivity were optimized and the linear dynamic range for determining of these drugs was found. The PLS modeling was used for the multivariate calibration of the spectrophotometric data and DOSC was used for preprocessing of data matrices and the prediction results of model. The experimental calibration matrix was designed by measuring the absorbance over the range 200-400 nm for 32 samples of 2.0-15.0 and 0.4-6.0 μg mL -1 of sulfamethoxazole and trimethoprim, respectively. The root mean square error of prediction for sulfamethoxazole and trimethoprim using DOSC-PLS and PLS were 0.02212, 0.02363 and 0.17014, 0.01660,μg mL -1 respectively. Application of the method to synthetic samples of standard solutions and in pharmaceutical formulation was performed and satisfactory results were obtained.

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Simultaneous spectrophotometric determination of diuretics by using multivariate calibration methods

Cited by 24 publications

References 14 publications

Spectrophotometric Analysis of Valsartan and Hydrochlorothiazide

Spectrophotometric Analysis of Valsartan and Hydrochlorothiazide

Ferrocenedicarboxylic acid modified carbon paste electrode: a sensor for electrocatalytic determination of hydrochlorothiazide

Direct Orthogonal Signal Correction-Partial Least Squares for Simultaneous Spectrophotometric Determination of Sulfamethoxazole and Trimethoprim in Pharmaceutical Formulation and Synthetic Samples

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