Simultaneous quantification of antibiotic dyes in aquatic products and feeds by liquid chromatography–tandem mass spectrometry

Chen, Rongchun; Wei, Kuen-Jou; Wang, Ter-Min; Yu, Yu-Man; Li, Juying; Lee, Shu‐Hui; Wang, Wei‐Hsien; Ren, Tyh-Jeng; Tsai, Chieh-Yuan

doi:10.1016/j.jfda.2013.09.001

Cited by 17 publications

(12 citation statements)

References 18 publications

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“…At present, LC-MS and GC-MS are two efficient and precise techniques to resolve the phytochemical profile of plant resources [16,17]. The former technique can identify semipolar metabolites with advantages of high precision and short time consumed.…”

Section: Phytochemical Profile Of P Tenuifolia Rootmentioning

confidence: 99%

Quality analysis of Polygala tenuifolia root by ultrahigh performance liquid chromatography–tandem mass spectrometry and gas chromatography–mass spectrometry

Jiang

et al. 2015

Journal of Food and Drug Analysis

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Polygala tenuifolia root is used as a functional food due to its attractive health benefits. In this study, ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and gas chromatography-mass spectrometry (GC-MS) were utilized to characterize the bioactive compounds in P. tenuifolia root. The UPLC-MS/MS information revealed 36 bioactive compounds, including oligosaccharide esters, polygalasaponins, and polygalaxanthones. GC-MS identified 34 volatile compounds with fatty acids as the main chemicals. The leading compound judged by UPLC-MS/MS was tenuifoliside A, and oleic acid was the leading volatile from GC-MS profiles. All samples tested showed similar bioactive compound compositions, but the level of each compound varied. Principal component analysis revealed the principal bioactive compounds with significant level variations between samples. These principal chemicals could be used for quality judgment of P. tenuifolia root, instead of measuring the levels of all compositional compounds.

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Section: Phytochemical Profile Of P Tenuifolia Rootmentioning

confidence: 99%

Quality analysis of Polygala tenuifolia root by ultrahigh performance liquid chromatography–tandem mass spectrometry and gas chromatography–mass spectrometry

Jiang

et al. 2015

Journal of Food and Drug Analysis

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“…Compared to UV‐Vis and fluorescence detection methods, LC‐MS/MS allows for simultaneous detection of triphenylmethane dyes, without post‐column oxidation and with superior sensitivity and selectivity (Ding et al., ). A few LC‐MS/MS methods have been proposed for the analysis of CV, LCV, MG, and/or LMG in fish (Ascari et al., ; Chen et al., ; Giaccome et al., ; Hurtaud‐Pessel, Couëdor, & Verdon, ; Lee et al., ; Xu et al., ), but none has yet received general acceptance. As confirmed by available reports, the potential for misuse and illegal use of triphenylmethane dyes in fish remains high (Andersen et al., ; Giaccome et al., ; Lee et al., ; Love, Rodman, Neff, & Nachman, ), which underscores the need for sensitive detection and widespread testing of fish products sold on various markets.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Triphenylmethane Dye Residues and their Leuco‐Forms in Frozen Fish by LC‐MS/MS, Fish Microbial Quality, and Effect of Immersion in Whole Milk on Dye Removal

Gammoh

Alu’datt

Alhamad

et al. 2019

Journal of Food Science

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A rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was validated and used to quantify crystal violet (CV), leucocrystal violet (LCV), malachite green (MG), leucomalachite green (LMG), and brilliant green (BG) residues in frozen fish (121 samples) from various countries, in order to detect the use of prohibited antibiotic dyes in fish for human consumption. The microbial quality of the fish was also assessed along with the effectiveness of a simple treatment with whole fat milk to reduce the levels of CV and LCV contamination. CV and LCV were the only two residues detected. They were found in farmed Pangasius (0.362 to 41.34 µg/kg and 0.178 to 10.58 µg/kg, respectively) and Tilapia (1.24 to 9.48 µg/kg and 1.29 to 2.81 µg/kg). Based on aerobic plate count (APC), 74%, 59%, and 55% of the samples of Tilapia fillets (from China) and Pangasius fillets (United Arab Emirates and Vietnam), and 100% and 50% of the skin samples of Hake (Argentina and U.S.A.) were of unacceptable microbial quality (APC > 10 7 cfu/g). Human pathogens, namely Escherichia coli, Staphylococcus aureus, and Vibrio spp., were detected in most fish. A significant reduction in CV and LCV concentrations by more than a third was achieved after immersing Pangasius and Tilapia fillets in whole fat milk for 120 minutes. These findings support the necessity of regular inspections and monitoring of CV and other antibiotic dye residues in fish, along with routine assessments of fish microbial quality, in order to protect public health. Practical Application: The described LC-MS/MS method can be used to rapidly and simultaneously quantify antibiotic dye residues in frozen fish. CV and LCV were detected in farmed Pangasius and Tilapia fillets and their concentrations was reduced by more than one third after immersing the fillets in whole milk for 120 min, a treatment which is not intended to replace safe fish farming practices upstream to artificially lower the level of banned dyes in fish. The findings support the necessity of regular inspections and monitoring of CV and other antibiotic dye residues in fish, along with assessments of fish microbial quality, to protect public health.

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“…3,7-bis(Dimethylamino)-phenothiazin-5-ium chloride or methylene blue (MB) is a heterocyclic aromatic compound which is conventionally used as a staining agent for animal cells and bacteria [8][9][10][11]. Despite its role as popularly used staining agent, MB is also known to be effective in some health applications; for instance, prevention and treatment of fungal infection of freshwater and saltwater fish [12], treatment methemoglobinemia [8] and potassium cyanide poisoning of human [13]. However, MB can be a potentially hazardous material since it is highly soluble in water and easily metabolized in animal tissues [12,14].…”

Section: Introductionmentioning

confidence: 99%

“…Despite its role as popularly used staining agent, MB is also known to be effective in some health applications; for instance, prevention and treatment of fungal infection of freshwater and saltwater fish [12], treatment methemoglobinemia [8] and potassium cyanide poisoning of human [13]. However, MB can be a potentially hazardous material since it is highly soluble in water and easily metabolized in animal tissues [12,14]. Accumulation of MB in biological tissues led to serious health effect due to its carcinogenicity [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Preparation of nanocrystalline cellulose-montmorillonite composite via thermal radiation for liquid-phase adsorption

Santoso

Laysandra

Putro

et al. 2017

Journal of Molecular Liquids

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Simultaneous quantification of antibiotic dyes in aquatic products and feeds by liquid chromatography–tandem mass spectrometry

Cited by 17 publications

References 18 publications

Quality analysis of Polygala tenuifolia root by ultrahigh performance liquid chromatography–tandem mass spectrometry and gas chromatography–mass spectrometry

Quality analysis of Polygala tenuifolia root by ultrahigh performance liquid chromatography–tandem mass spectrometry and gas chromatography–mass spectrometry

Analysis of Triphenylmethane Dye Residues and their Leuco‐Forms in Frozen Fish by LC‐MS/MS, Fish Microbial Quality, and Effect of Immersion in Whole Milk on Dye Removal

Preparation of nanocrystalline cellulose-montmorillonite composite via thermal radiation for liquid-phase adsorption

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