Simultaneous Prostatic Carcinoma and Genital Paget's Disease Associated with Subjacent Adenocarcinoma

Oka, Michimoto; Saita, Buzou; Nakashima, Kenji

doi:10.1111/j.1464-410x.1979.tb04247.x

Cited by 11 publications

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“…Although Paget's disease of the glans penis is rarely reported in the literature (17)(18)(19)(20)(21)(22)(23)(24)(25)(26), many cases have been associated with transitional cell carcinoma of the bladder. Genital Paget's disease without involvement of the glans penis is more commonly described, but is rarely associated with internal malignancy (27)(28)(29)(30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

Extramammary Paget's Disease: A Report of 22 Cases in Chinese Males

Chang

Liu

Wong

1996

The Journal of Dermatology

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Extramammary Paget's disease (EMPD) is more frequently seen in Caucasian females than in males (3.2:1 female:male ratio). During the past 14 year period, we have collected 22 patients, all Chinese males, with EMPD. They presented with eczema-like lesions in the early stages in the genital or perianal regions. Histological sections showed Paget cells within the epidermis or skin appendages and even within the dermis. No underlying adnexal carcinoma or adjacent internal carcinoma could be detected after thorough examinations. Mode of therapy and outcome are presented. EMPD seems to affect more males than females in Orientals. The incidence of concomitant malignancy in Chinese male patients with genital Paget's disease seems to be much lower than that in Caucasians. However, if EMPD involves the glans penis or perianal area, a search for internal malignancy is still warranted.

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Section: Discussionmentioning

confidence: 99%

Extramammary Paget's Disease: A Report of 22 Cases in Chinese Males

Chang

Liu

Wong

1996

The Journal of Dermatology

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Paget's disease primarily involving the scrotum

Pérez

LaRossa

Tomaszewski

1989

Cancer

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Three cases of Paget's disease primarily involving the scrotum are reported. One case exhibited positive staining for prostate specific antigen (PSA) and was associated with an underlying, invasive poorly differentiated adenocarcinoma of unknown primary. The other cases were not associated with any underlying or visceral malignancy. The literature on Paget's disease primarily involving the scrotum including clinical presentation, differential diagnosis, treatment, prognosis, and possible histogenetic mechanisms of this disease is discussed.

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Cytoreductive combination chemotherapy for regionally advanced unresectable extramammary Paget carcinoma

Voigt¹,

Basserrmann

Nafhrath

1992

Cancer

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Extramammary Paget carcinoma (EPC) is considered to originate from the eccrine and apocrine glands of the adnexal skin of the axilla, vulva or penis, scrotum, or perineum. If immunohistochemical techniques with the use of cytoskeletal markers are applied in addition to histologic examination, EPC lesions are found to be multifocal adenocarcinoma of the adnexal sweat glands. So far, therapeutic approaches have included primary surgery, followed optionally by radiation therapy. It is possible to achieve a cure only when manifestations are detected early and confined regionally. The role of palliative chemotherapy has not yet been assessed in this disease, particularly because of the lack of compliance and follow‐up in patients with EPC. Cancer 1992; 70:704–708.

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Simultaneous Prostatic Carcinoma and Genital Paget's Disease Associated with Subjacent Adenocarcinoma

Cited by 11 publications

References 1 publication

Extramammary Paget's Disease: A Report of 22 Cases in Chinese Males

Extramammary Paget's Disease: A Report of 22 Cases in Chinese Males

Paget's disease primarily involving the scrotum

Cytoreductive combination chemotherapy for regionally advanced unresectable extramammary Paget carcinoma

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