Paget's disease primarily involving the scrotum

Pérez, Manuel A.; LaRossa, Donato; Tomaszewski, John E.

doi:10.1002/1097-0142(19890301)63:5<970::aid-cncr2820630531>3.0.co;2-v

Cited by 31 publications

(20 citation statements)

References 33 publications

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“…The clinical characteristics of extramammary Paget's disease are not well understood, including the incidence, prognosis, and the relationship between the disease and its associated internal malignancy or underlying adnexal carcinoma. In the literature, most reports of extramammary Paget's disease were focused on the sites of the perineum and vulva; only some case reports or small series [5][6][7] addressed penoscrotal extramammary Paget's disease. Penoscrotal disease presents as erythematous, pruritic, and indurated lesions that may ulcerate and discharge.…”

Section: Discussionmentioning

confidence: 99%

Penoscrotal Extramammary Paget???s Disease: A Review of 33 Cases in a 20-Year Experience

Lai

Yang

Tsay

et al. 2003

Plastic and Reconstructive Surgery

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Extramammary Paget's disease in men most frequently involves the penoscrotal area. The uncertainty of the outcome and of the relationship to the underlying adnexal carcinoma and associated internal malignancy still exists. From 1982 to 2001, 33 patients with penoscrotal extramammary Paget's disease were treated and followed up. Therapeutic modalities included carbon dioxide laser ablation (two patients) and local wide excision (31 patients). Split-thickness skin graft (22 patients), local scrotal flap (six patients), and primary closure (three patients) were utilized to reconstruct the penoscrotal defects after local wide excision. An underlying adnexal carcinoma occurred in seven of 33 patients (21.2 percent). The incidence of associated internal malignancy was 9.1 percent (three of 33 patients), including one concurrently and two nonconcurrently associated malignancies. Eight of 33 patients had local recurrence, representing an incidence of 24.2 percent. Three patients (9.1 percent) had distant metastasis and ultimately died of metastatic carcinoma. Of these patients, 31 were grouped according to the degrees of involvement: limited to the epidermis (group 1, n = 14), involvement of the adnexal gland and/or hair follicle (group 2, n = 10), and the presence of an underlying adnexal carcinoma (group 3, n = 7). Local wide excision with subsequent reconstruction by split-thickness skin graft was favored in this series. Patients with an underlying adnexal carcinoma or pathological invasion of the dermis (group 2 or 3) had a worse prognosis than patients without. From this study, it is difficult to address the particular relationship between the outcome and the associated internal malignancy.

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Section: Discussionmentioning

confidence: 99%

Penoscrotal Extramammary Paget???s Disease: A Review of 33 Cases in a 20-Year Experience

Lai

Yang

Tsay

et al. 2003

Plastic and Reconstructive Surgery

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“…Since its first description in 1874 [3] of what is nowadays known as Paget's disease of the nipple, analogous lesions have been described in anogenital region, lower urinary tract, axilla, oral cavity and eyelids [4]. Darier and Coulillaud [5], in 1893, described the first patient with EMPD involving the perianal area.…”

Section: Discussionmentioning

confidence: 99%

Perianal Extramammary Paget’s Disease: Diagnosis, Treatment and Prognosis

Felice¹

2014

J Cytol Histol

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“…In women the site most often affected is the labium majora and in men the scrotum. 170 Size can range from a few millimeters to the entire anogenital area. Itching and burning are common symptoms.…”

Section: Monitoring Of Patients After Treatment or Therapymentioning

confidence: 99%