Simultaneous optical absorption and viscoelasticity imaging based on photoacoustic lock-in measurement

Zhao, Yue; Yang, Sihua; Chen, Conggui; Xing, Da

doi:10.1364/ol.39.002565

Cited by 52 publications

(43 citation statements)

References 21 publications

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“…1,4 In photoacoustic therapy, photoacoustic probes (or agents) are exposed to a pulsed laser, the light energy absorbed by photoacoustic probes can be converted into acoustic energy based on photoacoustic e®ect. [5][6][7][8][9][10][11][12][13][14] Then, the magnitude of photoacoustic amplitude can generate a strong shock wave, with peak pressure of 100 Mpa. 15 Such a strong shock wave can destroy the cell membrane, resulting in cell apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Indocyanine green loaded graphene oxide for high-efficient photoacoustic tumor therapy

Yan

Qin

2016

J. Innov. Opt. Health Sci.

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Photoacoustic therapy, using the photoacoustic e®ect of agents for selectively killing tumor cells, has shown promising for treating tumor. Utilization of high optical absorption probes can help to e®ectively improve the photoacoustic therapy e±ciency. Herein, we report a novel highabsorption photoacoustic probe that is composed of indocyanine green (ICG) and graphene oxide (GO), entitled GO-ICG, for photoacoustic therapy. The attached ICG with narrow absorption spectral pro¯le has strong optical absorption in the infrared region. The absorption spectrum of the GO-ICG solution reveals that the GO-ICG particles exhibited a 10-fold higher absorbance at 780 nm (its peak absorbance) as compared with GO. Importantly, ICG's°uorescence is quenched by GO via°uorescence resonance energy transfer. As a result, GO-ICG can high-e±ciently convert the absorbed light energy to acoustic wave under pulsed laser irradiation. We further demonstrate that GO-ICG can produce stronger photoacoustic wave than the GO and ICG alone. Moreover, we conjugate this contrast agent with integrin v 3 mono-clonal antibody to molecularly target the U87-MG human glioblastoma cells for selective tumor cell killing. Finally, our results testify that the photoacoustic therapy e±ciency of GO-ICG is higher than the existing photoacoustic therapy agent. Our work demonstrates that GO-ICG is a high-e±ciency photoacoustic therapy agent. This novel photoacoustic probe is likely to be an available candidate for tumor therapy.

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Section: Introductionmentioning

confidence: 99%

Indocyanine green loaded graphene oxide for high-efficient photoacoustic tumor therapy

Yan

Qin

2016

J. Innov. Opt. Health Sci.

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“…3. 43 Figure 3(a) shows the photography of four tissue-mimicking agar phantoms. The samples marked as \a," \b," \c" and \d" contain gelatin with the concentrations of 4%, 4%, 7% and 7%, respectively.…”

Section: Methods Of the Pave Imagingmentioning

confidence: 99%

“…Meanwhile, high-contrast PA phase-resolved viscoelastic images have been successfully achieved. The PAVE imaging technique has been applied to tumor detection, 43 atherosclerosis characterization [44][45][46] and vascular endoscopy. 47 It is believed that PAVE imaging has great potential in both biomedical applications and clinical studies.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic viscoelasticity imaging dedicated to mechanical characterization of biological tissues

Shi

Yang

Wang

2017

J. Innov. Opt. Health Sci.

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Since changes in mechanical properties of biological tissues are often closely related to pathology, the viscoelastic properties are important physical parameters for medical diagnosis. A photoacoustic (PA) phase-resolved method for noninvasively characterizing the biological tissue viscoelasticity has been proposed by Gao et al. [G. Gao, S. Yang, D. Xing, \Viscoelasticity imaging of biological tissues with phase-resolved photoacoustic measurement," Opt. Lett. 36, 3341-3343 (2011)]. The mathematical relationship between the PA phase delay and the viscosity-elasticity ratio has been theoretically deduced. Moreover, systems of PA viscoelasticity (PAVE) imaging including PAVE microscopy and PAVE endoscopy were developed, and high-PA-phase contrast images re°ecting the tissue viscoelasticity information have been successfully achieved. The PAVE method has been developed in tumor detection, atherosclerosis characterization and related vascular endoscopy. We reviewed the development of the PAVE technique and its applications in biomedical¯elds. It is believed that PAVE imaging is of great potential in both biomedical applications and clinical studies.

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“…PAT has been demonstrated capable of providing structural, functional, and metabolic information [12][13][14][15][16] . PAT has also successfully measured the elastic properties of biological tissue, including strain 5 , the viscosity-elasticity ratio 17 , and vascular compliance 18 . Yet, all the aforementioned photoacoustic elastic imaging techniques measure only relative elastic properties.…”

Section: Introductionmentioning

confidence: 99%

Quantitative photoacoustic elastography of Young’s modulus in humans

Hai

Zhou

Gong

et al. 2017

Photons Plus Ultrasound: Imaging and Sensing 2017

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Elastography can noninvasively map the elasticity distribution of biological tissue, which is often altered in pathological states. In this work, we report quantitative photoacoustic elastography (QPAE), capable of measuring Young's modulus of human tissue in vivo. By combining photoacoustic elastography with a stress sensor having known stress-strain behavior, QPAE can simultaneously measure strain and stress, from which Young's modulus is calculated. We first applied QPAE to quantify the Young's modulus of tissue-mimicking agar phantoms with different concentrations. The measured values fitted well with both the empirical expectations based on the agar concentrations and those measured in independent standard compression tests. We then demonstrated the feasibility of QPAE by measuring the Young's modulus of human skeletal muscle in vivo. The data showed a linear relationship between muscle stiffness and loading. The results proved that QPAE can noninvasively quantify the absolute elasticity of biological tissue, thus enabling longitudinal imaging of tissue elasticity. QPAE can be exploited for both preclinical biomechanics studies and clinical applications.

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Simultaneous optical absorption and viscoelasticity imaging based on photoacoustic lock-in measurement

Cited by 52 publications

References 21 publications

Indocyanine green loaded graphene oxide for high-efficient photoacoustic tumor therapy

Indocyanine green loaded graphene oxide for high-efficient photoacoustic tumor therapy

Photoacoustic viscoelasticity imaging dedicated to mechanical characterization of biological tissues

Quantitative photoacoustic elastography of Young’s modulus in humans

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