Simultaneous Occurrence of Myeloma and Hodgkin’s Disease

Abstract

A patient in whom lymphocyte-depleted Hodgkin’s disease and multiple myeloma were diagnosed simultaneously is reported. There was no prior history of irradiation or chemotherapy, the significance of which is discussed in relation to previously documented patients with Hodgkin’s disease and myeloma.

Solitary Plasmacytoma of the Bone in a Case of Hodgkin’s Disease

“…In accordance with our findings, also the cases reported both by Sacks et al [8], in which MM and HD occurred simultaneously and prior to any treatment, and by Greenberg et al [5], in which the diagnosis of MM was made soon after radiation th e r a p y f o r H D , se e m to s u p p o r t th e h y p o th e s is th a t myelomatosis may be unrelated to any previous im munosuppressive therapy. On the other hand, the ob servation by Cawley et al [4] of overt MM following combined chemotherapy for HD with alkylating agents, vinka alkaloids and procarbazine, made it tempting to implicate these drugs in the development of the second malignancy.…”

“…It has previously been described in 4 cases only [4,5,8]. In all of them, both the serum M component and a signi ficant infiltration of plasma cells in the bone marrow supported the diagnosis of overt MM.…”

“…This report describes a case of solitary plasmacytoma of the bone which occurred in a 35-year-old male 3 years after mantle field irradiation for Hodgkin's disease, nodular sclerosing, stage 1 A. The possible sig nificance of this rare association is discussed.The association of Hodgkin's disease (HD) and overt multiple myeloma (MM) has hitherto been de scribed in a few cases only [4,5,8]. We here report an other case, in which solitary plasmacytoma of the bone developed 3 years after the initial diagnosis of HD, nodular sclerosing, stage IA.…”

Concurrent Presentation of Hodgkin Lymphoma and Multiple Myeloma

“…Concurrent presentation of MM and HL in the absence of prior radiation or chemotherapy is rare and limited to case reports [1–5]. These patients are usually older than 50 which is typically the second age peak for HL incidence.…”

Simultaneous occurrence of Hodgkin's disease, nodal Langerhans' cell histiocytosis and multiple myeloma IgA(κ)

“…Only five other similar cases have been described in the literature [1-3, 14, 24], with a simultaneous diagnosis of both diseases occurring in only three of these [2,14,24]. The purpose of this paper is to present a new case in which, in addition, an isolated node showed Langerhans' cell histiocytosis (LCH).…”