Solitary Plasmacytoma of the Bone in a Case of Hodgkin’s Disease

Gherlinzoni, F.; Cavo, Michèle; Pileri, Stefano; Rivano, M.T.; Boriani, Stefano; Biagini, R.; Emiliani, E

doi:10.1159/000206049

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…This notion was echoed in the case reports of Gherlinzoni and Ibarrola. 15,19 In this vain, the more common course of HL followed by myeloma seems to correlate with the maturation of a B-cell neoplasm.…”

Section: Discussionmentioning

confidence: 99%

Hodgkin's lymphoma associated with plasma cell neoplasia: Cytological features and review of the literature

Oliai

Zakowski

Lin

2005

Diagnostic Cytopathology

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Hodgkin's lymphoma (HL) associated with plasma cell neoplasia is extremely rare. Here, we report one case diagnosed by fine-needle aspiration biopsy (FNAB) and review the clinical features of 15 previously reported cases. Our specimen was obtained by FNAB of an enlarged right inguinal lymph node. Air-dried Diff-Quik (DQ)-stained slides and alcohol-fixed slides stained with hematoxylin-eosin (H&E) and Papanicolaou stains were reviewed. The specimen was cellular, consisting of lymphocytes and plasma cells. Flow cytometric analysis revealed a monoclonal (M) plasma-cell population. Admixed large atypical mono- and binucleated cells immunoreactive for CD30 were noted also. A diagnosis of plasma-cell neoplasm associated with classic HL was confirmed histologically after surgical removal of the lymph node. The diagnosis of both HL and plasma-cell neoplasia in the same patient is exceedingly rare. Adding another case to the 15 previously reported cases was unique because our case was diagnosed through FNAB.

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Section: Discussionmentioning

confidence: 99%

Hodgkin's lymphoma associated with plasma cell neoplasia: Cytological features and review of the literature

Oliai

Zakowski

Lin

2005

Diagnostic Cytopathology

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“…To our knowledge no cases with MM preceding HD have been reported. Some patients have developed plasmocytoma [10,20], MM [1,3,11] or monotypic plasma cell proliferations of unknown significance [9] after HD therapy These proliferations were attributed to the carcinogenic risks associated with the therapy. There have been also some reports of simultaneous occurrence of HD and paraproteinaemia of uncertain significance [5,16,26,28], including one of a case with bone marrow plasmocytosis [26] and another with monotypic plasma cell proliferation in a lymph node [28].…”

Section: Discussionmentioning

confidence: 99%

Simultaneous occurrence of Hodgkin's disease, nodal Langerhans' cell histiocytosis and multiple myeloma IgA(κ)

et al. 1999

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A 35-year-old man suffered simultaneously from nodular sclerosis Hodgkin's disease (HD), Langerhans' cell histiocytosis and multiple myeloma (MM). There was no prior history of irradiation or chemotherapy, and clinically the lymphoma was confined to cervical lymph nodes. Immunohistochemically, neoplastic lymphoma cells reacted with CD15 and CD30 markers. The patient's bone marrow exhibited a diffuse infiltration by rather atypical plasma cells showing kappa immunoglobulin light-chain restriction. At 14 months after the diagnosis, after autologous bone marrow transplantation, the clinical evolution is favourable with complete remission of the diseases. This is the first time that the coexistence of these three haematological disorders has been discussed, and only the fourth documented case of simultaneous HD and MM. Speculations about the significance of this finding are discussed.

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“…In China, the annual incidence of MM is ~1 case/100,000 individuals (9,10). The simultaneous occurrence of two types of lymphatic system malignant tumor within the same patient is extremely rare, with an occurrence rate of 1.4-6.5 cases/1,000,000 individuals (15).…”

Section: A B C D F Ementioning

confidence: 99%

“…Previous studies have also reported the simultaneous occurrence of HL and chronic lymphocytic leukemia, peripheral T-cell lymphoma or diffuse large B-cell lymphoma (16)(17)(18). Furthermore, certain patients have developed plasmocytoma (15,19), MM (20,21) or monotypic plasma cell proliferations of unknown significance (22) following therapy for HL; it is unclear whether such secondary tumors are associated with the side effects of the first cancer treatment. Hasskarl et al (23) suggested that MM is associated with hematological neoplasms.…”

Section: A B C D F Ementioning

confidence: 99%

Simultaneous occurrence of Hodgkin's lymphoma and multiple myeloma: A case report and review of the literature

et al. 2016

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Abstract. Hodgkin's lymphoma (HL) is a type of hematological neoplasm that generally appears alone, with a low incidence. The majority of cases histopathologically present as B-cell lymphoma. Multiple myeloma (MM) is defined as the neoplastic proliferation of a single clone of plasma cells producing a monoclonal immunoglobulin (Ig). The coexistence of HL and MM is rare, however, the present study reports such a case. On May 31, 2012, a 45-year-old man was diagnosed with HL, stage III, 31 months ago. At the same time, computed tomography and magnetic resonance imaging showed osteolytic lesions, a significant increase in IgA λ chains, and multiple myeloma cells on bone marrow aspiration. Following 8 cycles of chemotherapy, the patient received maintenance treatment with thalidomide and dexamethasone. During 2 years of follow-up, the patient has maintained a complete response for HL and a stable disease state for MM. The coexistence of HL and MM is rare.Further study of such cases may explain the associations between these two tumors and aid the production of effective treatment options.

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Solitary Plasmacytoma of the Bone in a Case of Hodgkin’s Disease

Abstract: This report describes a case of solitary plasmacytoma of the bone which occurred in a 35-year-old male 3 years after mantle field irradiation for Hodgkin’s disease, nodular sclerosing, stage IA. The possible significance of this rare association is discussed.

Cited by 4 publications

References 4 publications

Hodgkin's lymphoma associated with plasma cell neoplasia: Cytological features and review of the literature

Hodgkin's lymphoma associated with plasma cell neoplasia: Cytological features and review of the literature

Simultaneous occurrence of Hodgkin's disease, nodal Langerhans' cell histiocytosis and multiple myeloma IgA(κ)

Simultaneous occurrence of Hodgkin's lymphoma and multiple myeloma: A case report and review of the literature

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