Simultaneous multiwavelength spectrophotometric quantitation of active components in analgesic formulations. Comparative study of three calculation methods

Determination of paracetamol: Historical evolution

“…The simultaneous determination of these three active components and other additional ones can be performed by using techniques such as spectrophotometric, having proposed various numerical methods such as Kalman filtering of UV data [110], multivariate programs using spectrophotometric data such as multicomponents analysis, Simplex and Multic [111], factor analysis [112], iterative-target transformation factor analysis [113] and stepwise regression method [114]. However, still now, no attempt was made to use PLS for the simultaneous determination of the aforementioned compounds.…”

Quantitative Analysis, Infrared

“…The simultaneous determination of these three active principles can be performed by using multivariate calibration. Various numerical methods were proposed in combination with molecular spectroscopy, such as Kalman filtering and UV data, 141 multiple linear regression of the NIR reflectance data 142 and multivariate programs applied to UV measurement such as multicomponent simplex analysis and multic, 143 target transformation factor, 143,144 step regression 145 and PLS regression. 120 The latter also developed a PLS/FTIR procedure for the fast and accurate simultaneous determination of paracetamol, acetylsalicylic acid and caffeine in commercial pharmaceutical formulations.…”

Resolution of a multicomponent polycyclic aromatic hydrocarbon system in micellar media by linear variable angle fluorescence applying distinct chemometric techniques†

“…For the application of the algorithm the MULTI3 11 program was used, which allows one to perform three different types of calibration: single standard, multiple standard and multiple standard addition.…”

“…10 On the other hand, the development of software specialized for chemometric techniques allows the application of powerful mathematical algorithms to resolve complex chemical systems by using multiple analytical signals which, owing to the interferences present in the determination, deviations from linearity, noise, etc., cannot be directly resolved. 11,12 Among these algorithms are multiple linear regression (MLR), principal component regression (PCR), partial least squares regression (PLS) and artificial neural networks (ANN). [13][14][15] Variable angle fluorescence combined with multicomponent analysis chemometric techniques has allowed the development of sensitive analytical methods for the simultaneous determination of PAH mixtures with satisfactory results, without requiring prior separation processes.…”