Simultaneous measurement of small birefringence magnitude and direction in real time

Liu, Longhai; Zeng, Aijun; Chen, Beishi; Li, Fanyue; Zhu, Linglin; Huang, Huijie

doi:10.1016/j.optlaseng.2013.08.008

Cited by 7 publications

(1 citation statement)

References 22 publications

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“…42,43 In the context of these fast imaging approaches, various proposed polarimetry methods to measure linear retardance, both magnitude and direction simultaneously, in real time, may also help shaping its roots in clinics of cardiac imaging. 44,45 Integrating polarimetry imaging with other optical modalities such as diffuse reflectance imaging is another convincingly emerging direction to potentially enhance signal strength, particularly for intraoperative tissue characterization. 46 Likewise, optical polarimetry in tandem with desorption electrospray ionization mass spectrometry imaging enabled 10-fold fast and accurate pathological (i.e., cancer) zone identification in ex vivo tissue slices.…”

Section: Polarimetric Characterization Of Myocardium In Clinics: Oppomentioning

confidence: 99%

Review of the emerging role of optical polarimetry in characterization of pathological myocardium

Ahmad¹

2017

J. Biomed. Opt

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Abstract. Myocardial infarction (MI), a cause of significant morbidity and mortality, is typically followed by microstructural alterations where the necrotic myocardium is steadily replaced with a collagen scar. Engineered remodeling of the fibrotic scar via stem cell regeneration has been shown to improve/restore the myocardium function after MI. Nevertheless, the heterogeneous nature of the scar patch may impair the myocardial electrical integrity, leading to the formation of arrhythmogenesis. Radiofrequency ablation (RFA) offers an effective treatment for focal arrhythmias where local heating generated via electric current at specific spots in the myocardium ablate the arrhythmogenic foci. Characterization of these myocardial pathologies (i.e., infarcted, stem cell regenerated, and RFA-ablated myocardial tissues) is of potential clinical importance. Optical polarimetry, the use of light to map and characterize the polarization signatures of a sample, has emerged as a powerful imaging tool for structural characterization of myocardial tissues, exploiting the underlying highly fibrous tissue nature. This study aims to review the recent progress in optical polarimetry pertaining to the characterization of myocardial pathologies while describing the underlying biological rationales that give rise to the optical imaging contrast in various pathologies of the myocardium. Future possibilities of and challenges to optical polarimetry in cardiac imaging clinics are also discussed.

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