Simultaneous mapping of epigenetic inter-haplotype, inter-cell and inter-individual variation via the discovery of jointly regulated CpGs in pooled sequencing data
Abstract:In the post-GWAS era, great interest has arisen in the mapping of epigenetic inter-individual variation towards investigating the emergence of phenotype in health and disease. Relevant DNA methylation methodologies – epigenome-wide association studies (EWAS), methylation quantitative traitloci(mQTL) mapping and allele-specific methylation (ASM) analysis – can each map certain sources of epigenetic variation and all depend on matching phenotypic/genotypic data. Here, to avoid these requirements, we developed Bi… Show more
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