Simultaneous malignant melanoma and squamous cell carcinoma of the oral cavity: A case report

Nakahara, Hirokazu; Kitamura, Ryosuke; Shirasuna, Kanemitsu

doi:10.1016/0278-2391(95)90676-2

Cited by 14 publications

(7 citation statements)

References 12 publications

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“…Gene therapy with the use of modified melanoma cells containing specific genes that code for cytokines, interferon and growth factors may be administered, such as tumor cell vaccines [12]. Immunotherapy may also be incorporated to melanoma treatment, although patient immune response may be significantly altered by the clinical course of the neoplasm [35]. Interleukin-2, interferon alpha, tumor-infiltrating lymphocytes, bacillus Calmette-Guerin, irradiated allogeneic tumor cells and monoclonal antibodies can be used [36].…”

Section: Review and Discussionmentioning

confidence: 99%

Oral and Cutaneous Melanoma: Similarities and Differences

et al. 2010

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Section: Review and Discussionmentioning

confidence: 99%

Oral and Cutaneous Melanoma: Similarities and Differences

et al. 2010

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“…However, collision tumors comprising squamous-cell carcinoma and melanoma are exceptional. The few previously documented cases of squamous-cell carcinoma and melanoma arising next to each other involved adults and occurred in the skin, oral and genital mucosa [1, 2, 3]. We herein describe a 13-year-old boy with xeroderma pigmentosum presenting a collision tumor comprising squamous-cell carcinoma and melanoma in situ on the nose.…”

Section: Introductionmentioning

confidence: 96%

Collision of Squamous-Cell Carcinoma with Melanoma in situ in a Child with Xeroderma pigmentosum

et al. 2001

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Coexistence (collision) of two different neoplasms in the same lesion has previously been documented by several authors. In this report, we describe a 13-year-old boy with xeroderma pigmentosum presenting with squamous-cell carcinoma and melanoma arising at the same site on the nose. Histopathologically, the melanoma component of the lesion was located mainly eccentrically to the squamous-cell carcinoma component. Immunohistochemical stains confirmed the histopathologic findings. Mutations for p53 assessed using single-strand conformation polymorphism, and sequencing analysis revealed a CC-to-TT transition at codon 159 of the p53 gene in the squamous-cell component but not in the melanoma component. This finding suggests a possible role for UV in the pathogenesis of at least the squamous-cell component of the tumor. To the best of our knowledge, this is the first report of a collision tumor comprising squamous-cell carcinoma and melanoma arising in childhood.

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“…Nakahara et al 9 related a clinical case of simultaneous OSCC and oral melanoma oral in a 74-year-old woman. The melanoma was localized in the anterior region of the maxilla, clinically shown as a tumor lesion presenting blackened color, while the OSCC was found in the molar region of the maxilla on the right side, shown as an ulcerated lesion.…”

Section: Discussionmentioning

confidence: 99%

“…The pigmented variant of OSCC is rare, and has been described in some of the few cases available in the literature, representing 0.01% to 7% of all the cases of OSCC 6 , presenting the same biologic behavior as the non-pigmented variant 5,6 . The pigmentation present in the tumor results from a larger deposition of melanin in the neoplastic cells, suggesting a possible stimulus of tumor cells for the proliferation and deposition by melanocytes present in the region 7,8 . In the literature, the involvement of OSCC with other pigmented malignancies has also been related, such as oral melanoma, which is a rare malignant neoplasm arising from melanocytes present in the oral cavity 9,10 . However, there are no reports demonstrating involvement of OSCC with benign neoplasms of melanocytic origin, such as blue cell nevus, which is a benign melanocytic lesion shown mainly in women, with the palate being the most affected anatomic site in the oral cavity, exhibiting variation from a blue to blackened color 11 .…”

Section: Introductionmentioning

confidence: 99%

Oral squamous cell carcinoma involving a blue cell nevus in the palate

Barnabé¹,

Paz²,

Gomes³

et al. 2017

JORDI - Journal of Oral Diagnosis

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Introduction: Squamous Cell Carcinoma (SCC) is the most common malignant neoplasm of the oral cavity; however, there is no report in the literature of SCC involved with blue nevus. Case report: We report the case of a patient, a 54-year-old woman who exhibited a brownish spot associated with whitish area, surrounded by a hyperemic area in the soft palate. After an incisional biopsy and histopathological analysis, the presence of invasive squamous cell carcinoma was shown, in addition, in other fragment, to the presence of fusiform cells disposed parallel to the epithelium, exhibiting intense brownish cytoplasmic pigments. Immunohistologically, the neoplastic epithelial cells demonstrated intense immunoexpression for the anti-pan Cytokeratin antibody, while the fusiform cells showed strong immunopositivity for the anti-S-100 and anti-Melan-A antibodies, and weak immunomarking for anti-HMB-45. Based on the microscopic findings described, the final diagnosis was Oral Squamous Cell Carcinoma (OSCC) involving a blue cell nevus. Conclusion: Therefore, we sought to relate the first case of involvement of OSCC and blue cell nevus, up to the present time.

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Simultaneous malignant melanoma and squamous cell carcinoma of the oral cavity: A case report

Cited by 14 publications

References 12 publications

Oral and Cutaneous Melanoma: Similarities and Differences

Oral and Cutaneous Melanoma: Similarities and Differences

Collision of Squamous-Cell Carcinoma with Melanoma in situ in a Child with Xeroderma pigmentosum

Oral squamous cell carcinoma involving a blue cell nevus in the palate

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