Collision of Squamous-Cell Carcinoma with Melanoma in situ in a Child with Xeroderma pigmentosum

Abstract

Coexistence (collision) of two different neoplasms in the same lesion has previously been documented by several authors. In this report, we describe a 13-year-old boy with xeroderma pigmentosum presenting with squamous-cell carcinoma and melanoma arising at the same site on the nose. Histopathologically, the melanoma component of the lesion was located mainly eccentrically to the squamous-cell carcinoma component. Immunohistochemical stains confirmed the histopathologic findings. Mutations for p53 assessed using single-strand conformation polymorphism, and sequencing analysis revealed a CC-to-TT transition at codon 159 of the p53 gene in the squamous-cell component but not in the melanoma component. This finding suggests a possible role for UV in the pathogenesis of at least the squamous-cell component of the tumor. To the best of our knowledge, this is the first report of a collision tumor comprising squamous-cell carcinoma and melanoma arising in childhood.

Collision Tumour of Squamous Cell Carcinoma and Malignant Melanoma in the Oral Cavity of a Dog

“…In addition, papillomavirus has been incriminated in melanoma development and progression in man (Hofer et al, 2001). The integration of viral genome into host cell DNA, affecting the p53 tumour suppressor gene and favouring the destabilization of the host genome, has been demonstrated in SCC and MM in human medicine (Hofer et al, 2001). In the current case, although p53 was increased in both cellular components, the absence of hyperplastic epithelium with viral cytopathic effect and papillomavirus immunolabelling did not indicate viral participation.…”

“…Although papillomavirus-associated malignant transformation has been incriminated in sunlight exposed areas, due to the prevention of apoptosis of cells that contain DNA damaged by UV-light, a relationship to carcinogenesis has not been fully elucidated. In addition, papillomavirus has been incriminated in melanoma development and progression in man (Hofer et al, 2001). The integration of viral genome into host cell DNA, affecting the p53 tumour suppressor gene and favouring the destabilization of the host genome, has been demonstrated in SCC and MM in human medicine (Hofer et al, 2001).…”

A Rare Case of a Cutaneous Squamomelanocytic Tumor: Revisiting the Histogenesis of Combined Neoplasms

“…Field cancerization theory explains the development of 2 neoplastic components within 1 lesion with the potential for recurrent damages to the skin (such as due to UV radiation) to trigger the proliferation of collision tumors within a concerned field. In support of this theory are a few reports about the development of collision tumors in old burn scars, xeroderma pigmentosum, 9 and solar damaged skin. 8 However, in the case of a SMT arising in a child with xeroderma pigmentosum, 9 it has been shown that mutations for the p53 gene related to chronic UV exposure were found only in the SCC component, which rather disfavors the authenticity of this theory.…”

Contiguous lesions in lentigo maligna

“…Malignant melanoma has been reported to coincide with basal cell carcinoma and SK as well as solar lentigo. [10][11][12][13][14][15] Green et al 16 performed a casecontrol study of 232 cases of cutaneous melanoma and found a statistical association with basal cell carcinoma, squamous cell carcinoma, and AK/SK. They found a 4-fold increase in the risk of melanoma (LM, superficial spreading, and nodular types) with all types of actinic tumors.…”