Simultaneous inhibition of growth and metastasis of hepatocellular carcinoma by co-delivery of ursolic acid and sorafenib using lactobionic acid modified and pH-sensitive chitosan-conjugated mesoporous silica nanocomplex

Zhao, Rui; Li, Tao; Zheng, Guirong; Jiang, Kai; Fan, Lulu

doi:10.1016/j.biomaterials.2017.07.030

Cited by 172 publications

(80 citation statements)

References 53 publications

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“…Yet, higher concentrations than 100 nM of the LeX mimetic compounds, although not being cytotoxic, reduced their beneficial profile, in a manner similar to observations on PSA-mimicking compounds [21]. It is either reported that the here identified LeX mimetic compounds are able to internalize into cells [36–38] or that they pass the plasma membrane due to their hydrophobic properties [39, 40]. The possibility that the intracellular presence of the LeX mimetic compounds leads to a reduction in beneficial effects remains to be investigated.…”

Section: Discussionsupporting

confidence: 52%

Enhanced Neuronal Survival and Neurite Outgrowth Triggered by Novel Small Organic Compounds Mimicking the LewisX Glycan

et al. 2018

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Glycosylation fine-tunes signal transduction of adhesion molecules during neural development and supports synaptic plasticity and repair after injury in the adult nervous system. One abundantly expressed neural glycan is LewisX (LeX). Although it is known that its expression starts at the formation of the neural tube during the second embryonic week in the mouse and peaks during the first postnatal week, its functional relevance is only rudimentarily understood. To gain better insights into the functions of this glycan, we identified small organic compounds that mimic structurally and functionally this glycan glycosidically linked to several neural adhesion molecules. Mimetic compounds were identified by competitive enzyme-linked immunosorbent assay (ELISA) using the LeX-specific monoclonal antibodies L5 and SSEA-1 for screening a library of small organic molecules. In this assay, antibody binding to substrate-coated LeX glycomimetic peptide is measured in the presence of compounds, allowing identification of molecules that inhibit antibody binding and thereby mimic LeX. Gossypol, orlistat, ursolic acid, folic acid, and tosufloxacin inhibited antibody binding in a concentration-dependent manner. With the aim to functionally characterize the molecular consequences of the compounds' actions, we here present evidence that, at nM concentrations, the mimetic compounds enhance neurite outgrowth and promote neuronal survival of cultured mouse cerebellar granule cells via, notably, distinct signal transduction pathways. These findings raise hopes that these LeX mimetics will be powerful tools for further studying the functions of LeX and its effects in acute and chronic nervous system disease models. It is worth mentioning in this context that the LeX compounds investigated in the present study have been clinically approved for different therapies.

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Section: Discussionsupporting

confidence: 52%

Enhanced Neuronal Survival and Neurite Outgrowth Triggered by Novel Small Organic Compounds Mimicking the LewisX Glycan

et al. 2018

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“…Subsequently, the zeta potential was increased to +42.1 mV after Cys grafting (pSiO 2 ‐ss‐NH 2 ). After conjugated with HA/CHI, the zeta potential was +34.4 mV . The change in zeta potentials is agreement with the modification each step.…”

Section: Resultsmentioning

confidence: 99%

Preparation of Triple‐Responsive Porous Silica Carriers and Carbon Quantum Dots for Photodynamic‐/Chemotherapy and Multicolor Cell Imaging

Chen

Zhao

et al. 2020

ChemNanoMat

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Photosensitive carbon quantum dots (CQDs) provide a new route to treat cancer owing to their ability to produce singlet oxygen. In this paper, pH/redox/enzyme‐responsive porous silica‐based carriers with CQDs were constructed for photodynamic‐chemical combination therapy. The porous silica (pSiO2) sample comprises uniform spheres with center‐radial channels, which is favorable for drug loading and delivery. CQDs with a size of 2.5 nm were synthesized and have the excellent ability to generate singlet oxygen. After loading CQDs and drug molecules, the channels of pSiO2 carrier were blocked with hyaluronic acid (HA)/chitosan (CHI) layer. The disulfide bonds, conjugating HA to the surface of pSiO2 carrier, would achieve redox‐responsive drug release, while breaking disulfide bonds and the HA/CHI layer could endow the pSiO2 carrier enzyme/pH‐responsive drug release. The prepared pSiO2 carriers display low cytotoxicity and good biocompatibility for multicolor imaging and photodynamic‐/chemotherapy.

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“…In addition, galactosamine can recognize and bind to the asialoglycoprotein receptor on the surface of hepatocellular carcinoma cells, and a galactosamine-mediated drug-delivery carrier was significant for targeted liver cancer therapy. 262,263 Glycyrrhizin, glycyrrhetinic acid, and mannose can serve as the guiding group in liver-targeted drug-delivery systems, with good potential. [264][265][266][267][268][269][270] As natural endogenous ligands, bile acids have good biocompatibility and are ideal routes for targeting hepatocellular cancer.…”

Section: Low-density Lipoprotein-modified Nanocarriersmentioning

confidence: 99%

<p>Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment</p>

Fan

et al. 2019

IJN

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Cancer is a major public health problem, and is now the world's leading cause of death. Traditional Chinese medicine (TCM)-combination therapy is a new treatment approach and a vital therapeutic strategy for cancer, as it exhibits promising antitumor potential. Nanotargeted drug-delivery systems have remarkable advantages and allow the development of TCM-combination therapies by systematically controlling drug release and delivering drugs to solid tumors. In this review, the anticancer activity of TCM compounds is introduced. The combined use of TCM for antitumor treatment is analyzed and summarized. These combination therapies, using a single nanocarrier system, namely codelivery, are analyzed, issues that require attention are determined, and future perspectives are identified. We carried out a systematic review of .280 studies published in PubMed since 1985 (no patents involved), in order to provide a few basic considerations in terms of the design principles and management of targeted nanotechnology-based TCM-combination therapies.

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Simultaneous inhibition of growth and metastasis of hepatocellular carcinoma by co-delivery of ursolic acid and sorafenib using lactobionic acid modified and pH-sensitive chitosan-conjugated mesoporous silica nanocomplex

Cited by 172 publications

References 53 publications

Enhanced Neuronal Survival and Neurite Outgrowth Triggered by Novel Small Organic Compounds Mimicking the LewisX Glycan

Enhanced Neuronal Survival and Neurite Outgrowth Triggered by Novel Small Organic Compounds Mimicking the LewisX Glycan

Preparation of Triple‐Responsive Porous Silica Carriers and Carbon Quantum Dots for Photodynamic‐/Chemotherapy and Multicolor Cell Imaging

<p>Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment</p>

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