Simultaneous high-performance liquid chromatographic stability-indicating analysis of acetaminophen and codeine phosphate in tablets and capsules

Sisco, W.R.; Rittenhouse, C. T.; Everhart, Lisa A.

doi:10.1016/s0021-9673(01)92459-8

Cited by 17 publications

(3 citation statements)

References 10 publications

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“…Codeine phosphate concentrations were measured using a modified stability-indicating high-performance liquid chromatographic (HPLC) method. [2][3][4] The HPLC system used has been described previously. 5 The reverse-phase column g was used at room temperature.…”

Section: Methodsmentioning

confidence: 99%

Stability of codeine phosphate in an extemporaneously compounded syrup

Dentinger

Swenson

2007

American Journal of Health-System Pharmacy

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Section: Methodsmentioning

confidence: 99%

Stability of codeine phosphate in an extemporaneously compounded syrup

Dentinger

Swenson

2007

American Journal of Health-System Pharmacy

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“…Tylenol 3 tablet extraction was based on a published procedure40 with some modifications. The tablet was added to 75 mL of extraction solvent (50 mL of double deionized water adjusted to pH 4 with phosphoric acid, and 50 mL of methanol), and mechanically shaken for 4 h. The solution was filtered through a 0.45 μm Nylon 66 filter and the filtrate adjusted to pH 9.5 by adding drops of 1 M NaOH.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of a hydrogen laser vacuum ultraviolet source for photoionization mass spectrometry of pharmaceuticals

Finch

Toerne

Schram

et al. 2004

Rapid Comm Mass Spectrometry

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A photoionization hydrogen laser time-of-flight mass spectrometer system (H2-TOFMS) has been evaluated for the rapid analysis of drugs of abuse and pharmaceutical agents extracted from prescription tablets and spiked urine samples. The spectra obtained using the H2-TOFMS showed primarily intact molecular ions (M+*) after introduction by a heated probe and irradiation with vacuum ultraviolet (VUV) photons from the laser. Samples analyzed by this technique required only a simple solid-phase extraction step; no chromatographic separation or derivatization was necessary to identify the drugs of abuse or pharmaceutical agents.

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“…In last decade several methods have been developed for the determination of PAR and COD . Some analytical techniques have also been used for the simultaneous determination of PAR and COD, such as spectrophotometry , high‐performance liquid chromatography (HPLC) , electrochemistry , electrophoresis and thermogravimetric analysis . However, to date, no work has been reported on the use of chemiluminescence (CL) methods for the simultaneous determination of PAR and COD.…”

Section: Introductionmentioning

confidence: 99%

Multiway analysis applied to time‐resolved chemiluminescence for simultaneous determination of paracetamol and codeine in pharmaceuticals

et al. 2016

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This method is based on the enhancing effect of codeine (COD) and paracetamol (PAR) on the chemiluminescence (CL) reaction of Ru(phen)3 (2+) with Ce(IV). In the batch mode, COD gives a relatively sharp peak with the highest CL intensity at 4.0 s, whereas the maximum CL intensity of the PAR appears at ~60 s after injection of Ce(IV) solution. Whole CL time profiles allowed use of the time-resolved CL data in combination with multiway calibration techniques, as multiway partial least squares (N-PLS), for the quantitative determination of both COD and PAR in binary mixtures. In this work, we found that the impact of Ce(IV) concentration on the CL intensity was different for COD and PAR. Therefore, a Ce(IV) concentration mode was added to the time and sample modes to obtain 3D data. The percent relative standard deviation (%RSD) values for 10 determinations of 1.0 × 10(-5) mol/L of COD and 1.0 × 10(-4) mol/L of PAR were 6.1% and 8.7%, respectively. The limit of detection (LOD) values (S/N = 3) were 0.9 × 10(-8) mol/L and 1.0 × 10(-6) mol/L for COD and PAR, respectively. The proposed method was successfully applied to the determination of PAR and COD in commercial pharmaceutical formulations. Acceptable recoveries (90-110%) were obtained for the quantification of these drugs in the real samples. Copyright © 2016 John Wiley & Sons, Ltd.

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Simultaneous high-performance liquid chromatographic stability-indicating analysis of acetaminophen and codeine phosphate in tablets and capsules

Cited by 17 publications

References 10 publications

Stability of codeine phosphate in an extemporaneously compounded syrup

Stability of codeine phosphate in an extemporaneously compounded syrup

Evaluation of a hydrogen laser vacuum ultraviolet source for photoionization mass spectrometry of pharmaceuticals

Multiway analysis applied to time‐resolved chemiluminescence for simultaneous determination of paracetamol and codeine in pharmaceuticals

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