Simultaneous extraction and quantitation of fentanyl and norfentanyl from primate plasma with LC/MS detection

Koch, David E.; Isaza, Ramiro; Carpenter, James W.; Hunter, R. P.

doi:10.1016/s0731-7085(03)00652-6

Cited by 42 publications

(35 citation statements)

References 12 publications

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“…The fragmentation of fentanyls has been described in detail previously. 5,13,30 Mixtures of all nine amphetamines were analysed by both AP-DIOS-MS/MS and AP-MALDI-MS/MS to determine the applicability of the techniques in the unequivocal identification of a single analyte in a sample, including several compounds of the same type. The protonated molecules of the compounds (Figs 1(a) and 2(a)) were isolated automatically in sequence and fragmented by MS/MS during one run from one spot.…”

Section: Resultsmentioning

confidence: 99%

Analysis of amphetamines and fentanyls by atmospheric pressure desorption/ionization on silicon mass spectrometry and matrix‐assisted laser desorption/ionization mass spectrometry and its application to forensic analysis of drug seizures

Pihlainen

Grigoras²,

Franssila³

et al. 2005

J. Mass Spectrom.

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The suitability of atmospheric pressure desorption/ionization on silicon mass spectrometry (AP-DIOS-MS) and matrix-assisted laser desorption ionization mass spectrometry (AP-MALDI-MS) for the identification of amphetamines and fentanyls in forensic samples was studied. With both ionization techniques, the mass spectra recorded showed abundant protonated molecules, and the background did not disturb the analysis. The use of tandem mass spectrometry (MS/MS) allowed unambiguous identification of the amphetamines and fentanyls. AP-DIOS-MS/MS and AP-MALDI-MS/MS were also successfully applied to the identification of authentic compounds from drug seizures. Common diluents and tablet materials did not disturb the analysis and compounds were unequivocally identified. The limits of detection (LODs) for amphetamines and fentanyls with AP-DIOS-MS/MS were 1-3 pmol, indicating excellent sensitivity of the method. The LODs with AP-MALDI-MS/MS were about 5-10 times higher.

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Section: Resultsmentioning

confidence: 99%

Analysis of amphetamines and fentanyls by atmospheric pressure desorption/ionization on silicon mass spectrometry and matrix‐assisted laser desorption/ionization mass spectrometry and its application to forensic analysis of drug seizures

Pihlainen

Grigoras²,

Franssila³

et al. 2005

J. Mass Spectrom.

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“…Immunoassay [20][21][22][23], high-performance liquid chromatography combined with ultraviolet detection [24], and several gas chromatographic methods [25][26][27][28] have been described. More recent studies were mostly based on liquid chromatography-mass spectrometry [29] or liquid chromatography-tandem mass spectrometry (LC-MS-MS) techniques [30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Fatal outcome in a child after ingestion of a transdermal fentanyl patch

et al. 2006

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The case history and toxicological findings of a fatal fentanyl intoxication due to ingestion of a transdermal patch are presented. A 1-year-old otherwise healthy girl was put to bed and 2 h later she was found dead. The autopsy revealed a 25-microg/h (4.2 mg) transdermal fentanyl patch in the stomach. Toxicological analysis by liquid chromatography-tandem mass spectrometry with positive electrospray ionization yielded fentanyl and norfentanyl concentrations in the peripheral blood of 5.6 and 5.9 ng/ml, heart blood 19.0 and 8.9 ng/ml, and liver 235 and 26 ng/g, respectively. The cause of death was determined to be a fentanyl overdose. The investigation established that the child has unintentionally swallowed the patch, which had been lying on the floor.

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“…Highly sensitive methods of analysis for fentanyl have been established with gas chromatography (GC) and high-performance liquid chromatography (HPLC), especially in human plasma, hair or urine [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] . Nevertheless, very few methods of the degradation of fentanyl are reported in literatures.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Degradation of Fentanyl in Aqueous Solutions of Peroxides and Hypochlorites

Qi¹,

Cheng²,

Zuo³

et al. 2011

DSJ

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Fentanyl widely used in clinics as practices is potentially utilised as an incapacitant in countering terrorism and its analogues would be used as an addictive drug, so the degradation of these compounds need to be investigated for protecting environment and human health. In this work, the degradation of fentanyl was examined in a series of oxidant aqueous solutions. Meanwhile, the degradation pathways of fentanyl in the oxidant solution were discussed according to all products identified by GC/MS and LC/MS.

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Simultaneous extraction and quantitation of fentanyl and norfentanyl from primate plasma with LC/MS detection

Cited by 42 publications

References 12 publications

Analysis of amphetamines and fentanyls by atmospheric pressure desorption/ionization on silicon mass spectrometry and matrix‐assisted laser desorption/ionization mass spectrometry and its application to forensic analysis of drug seizures

Analysis of amphetamines and fentanyls by atmospheric pressure desorption/ionization on silicon mass spectrometry and matrix‐assisted laser desorption/ionization mass spectrometry and its application to forensic analysis of drug seizures

Fatal outcome in a child after ingestion of a transdermal fentanyl patch

Oxidative Degradation of Fentanyl in Aqueous Solutions of Peroxides and Hypochlorites

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