Simultaneous enantioselective determination of phenylpyrazole insecticide flufiprole and its chiral metabolite in paddy field ecosystem by ultra-high performance liquid chromatography/tandem mass spectrometry

The evolution of insecticide resistance in the brown planthopper (Nilaparvata lugens Stål) of China in the period 2012–2016

“…Flufiprole is a novel kind of phenylpyrazole insecticide developed by Dalian Raiser Pesticide Co., Ltd., China 35 . Most populations of N .…”

Simultaneous Enantioselective Determination of Two New Isopropanol-Triazole Fungicides in Plant-Origin Foods Using Multiwalled Carbon Nanotubes in Reversed-Dispersive Solid-Phase Extraction and Ultrahigh-Performance Liquid Chromatography–Tandem Mass Spectrometry

“…Until now, a larger number of pioneer publications indicated that the polysaccharide-type CSPs based on cellulose and amylose derivatives exhibit a good enantiomer resolving ability toward chiral triazole fungicides. Among those commercial CSPs, Lux Cellulose-1, Lux Amylose-2, Chiral MZ(2)-RH, Chiral MJ(2)-RH, and Chiral MX(2)-RH have been reported to afford powerful chiral recognition ability toward a large number of chiral compounds. , Therefore, in the present investigation, the relative enantiomer resolving ability of mefentrifluconazole and ipfentrifluconazole was first evaluated on these five chiral columns. The results of the enantiomer resolving ability test of two studied analytes on five different polysaccharide-based chiral columns with four different mobile phases are shown in Figures S1 and S2.…”

“…The analysis of control samples (orange, grape, cucumber, potato, wheat, and soybean) was performed to verify the absence of interfering compounds around the retention time of target analytes. The slope ratio of the matrix-matched calibration curve/solvent calibration curve was calculated to evaluate the matrix effect . The LOQ was regarded as the lowest fortified concentration that was validated with acceptable recoveries .…”

“…A large number of pioneer research works have been done for an investigation into the enantioselective separation of triazole fungicides using chiral high-performance liquid chromatography (HPLC) with a UV detector. ,,− However, the residue determination of these chiral fungicide enantiomers/stereoisomers at low concentrations in complex samples is a serious challenge for HPLC-UV detection due to its low specificity and sensitivity. , By contrast, ultrahigh-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) has been proved a much promising alternative technique that overcomes the majority of the disadvantages of the currently established methods. As long as the stereoisomers of the target compounds are chromatographically separated, further selectivity might not be needed on part of the chiral stationary phases (CSPs) due to the very high specificity of MS/MS detection, which facilitates the simultaneous determination of a range of chiral agrochemicals or pollutions in complex matrixes, e.g., plant-origin foods. , However, although numerous research works have been done for the stereoselective determination of some chiral triazole fungicides with UPLC–MS/MS in recent years, − the real applicability of this technique to chiral detection of mefentrifluconazole and ipfentrifluconazole in plant-origin food matrixes is currently not available.…”

“…As long as the stereoisomers of the target compounds are chromatographically separated, further selectivity might not be needed on part of the chiral stationary phases (CSPs) due to the very high specificity of MS/MS detection, which facilitates the simultaneous determination of a range of chiral agrochemicals or pollutions in complex matrixes, e.g., plant-origin foods. 1,11 However, although numerous research works have been done for the stereoselective determination of some chiral triazole fungicides with UPLC−MS/MS in recent years, 12−15 the real applicability of this technique to chiral detection of mefentrifluconazole and ipfentrifluconazole in plant-origin food matrixes is currently not available.…”