Simultaneous enantioselective determination of 22 chiral pesticides in fruits and vegetables using chiral liquid chromatography coupled with tandem mass spectrometry

Enantioseparation of flurbiprofen enantiomers using chiral ionic liquids by liquid‐liquid extraction

“…Chromatography and electrochemical methods are mainly used for the analysis of enantiomers, currently. [25][26][27] However, chiral liquid-liquid extraction which applies the liquidliquid extraction technology to racemate separation is the most prospective method to scale-up because of low energy consumption, simple equipment requirements and mild operating conditions. 16,[28][29][30][31][32][33] Tang et al 34 reported enantioselective partitioning of flurbiprofen enantiomers in a biphasic recognition chiral extraction (BRCE) system combining a hydrophobic Ltartrate in organic phase and hydrophilic-cyclodextrin derivative in aqueous phase, which preferentially recognize R-enantiomer and S-enantiomer, respectively.…”

Enantioseparation and Determination of Penconazole in Rat Plasma by Chiral LC-MS/MS: Application to a Stereoselective Toxicokinetic Study

“…Based on the literature mentioned above [ 10 , 15 , 16 ], three polysaccharide-based columns (Chiralpak IA, Chiralpak IB and Chiralpak IC) were tested to separate penconazole enantiomers. In the case of Chiralpak IA, only partial separation (Rs = 0.52) of rac-penconazole was observed by using acetonitrile–water or methanol–water as the mobile phase.…”

“…The study demonstrated that the Chiralpak IC column showed superior enantioselectivity toward rac-penconazole (α ≥ 1.46 and R ≥ 6.59), applying n -hexane or petroleum ether as mobile phase and ethanol or isopropanol as a modifier. Zhao et al [ 16 ] separated penconazole enantiomers in reversed-phase mode using an amylose-based CSP (Chiralpak IG) with acetonitrile and ultrapure water containing ammonium acetate and formic acid as mobile phase, and the retention times of (+)-and (−)-penconazole were 16.8 min and 18.1 min, respectively. In addition, one group [ 15 ] studied the enantioseparation of rac-penconazole on the cellulose-based CSPs (Lux Cellulose-2).…”

Current Strategies for Studying the Natural and Synthetic Bioactive Compounds in Food by Chromatographic Separation Techniques

“…As it can be observed, liquid chromatography is particularly appropriate for the analysis of polar, non-volatile, and/or thermally labile pesticides. Because of its high selectivity and sensitivity, HPLC and UHPLC in combination with MS/MS have mostly been used in this field especially to determine the insecticides and herbicides belonging to organophosphorus compounds, imidazolinone and pyridine carboxylic acid derivatives, and in study of samples containing multiclass pesticides [16][17][18][19][20][21][22][23][24]27,[30][31][32][33][34]. However, in a few cases, i.e., triazine and phenylurea herbicides, the HPLC coupled with spectrophotometric detection HPLC-UV or DAD has also been applied [25,26,28].…”