Simultaneous dual-isotope SPECT/CT with 99mTc- and 111In-labelled albumin microspheres in treatment planning for SIRT

Palmowski, Moritz; Goedicke, Andreas; Vogg, Andreas; Christ, Götz; Mühlenbruch, Georg; Kaiser, Hartmut; Günther, Rolf W.; Kuhl, Christiane K.; Mottaghy, Felix M.; Behrendt, Florian F.

doi:10.1007/s00330-013-2916-9

Cited by 10 publications

(7 citation statements)

References 14 publications

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“…Representative HSA drugs based on in vitro conjugation: (a) 111 In-labeled HSA for single-photon emission computed tomography (SPECT); 51 (b) Gd-labeled HSA for magnetic resonance imaging (MRI); 52 (c) 68 Ga-labeled HSA for positron emission tomography (PET); 53 (d) doxorubicin HSA conjugates for cancer chemotherapy with less side effect; 54 (e) 18 F-labeled HSA conjugates for PET; 44 (f) CysCOOH HSA conjugates for photothermal therapy; 55 (g) 3,5-diiodo-thyronine HSA conjugates for antibody production in animals; 56 (h) exendin-4 peptide HSA conjugates for the treatment of type 2 diabetes. 57 …”

Section: Figmentioning

confidence: 99%

“…6A and B) have been widely used in clinical diagnosis, especially for lung perfusion and for detecting gastrointestinal bleeding by SPECT. 20,51,[81][82][83] To form this self-assembled capsule, firstly the intramolecular disulfide bonds of HSA are partially reduced by using glutathione (GSH) to give free sulfhydryl groups. Then, the pretreated HSA/ water solution is mixed with small drugs in triaryl butyl alcohol (TBA).…”

Section: In Vitro Non-covalent Hsa Bindingmentioning

confidence: 99%

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Simple bioconjugate chemistry serves great clinical advances: albumin as a versatile platform for diagnosis and precision therapy

2016

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Albumin is the most abundant circulating protein in plasma and has recently emerged as a versatile protein carrier for drug targeting and for improving the pharmacokinetic profile of peptide or protein based drugs. Three drug delivery technologies related to albumin have been developed, which include the coupling of low-molecular weight drugs to exogenous or endogenous albumin, conjugating bioactive proteins by albumin fusion technology (AFT), and encapsulation of drugs into albumin nanoparticles. This review article starts with a brief introduction of human serum albumin (HSA), and then summarizes the mainstream chemical strategies of developing HSA binding molecules for coupling with drug molecules. Moreover, we also concisely condense the recent progress of the most important clinical applications of HSA-binding platforms, and specify the current challenges that need to be met for a bright future of HSA-binding.

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Section: Figmentioning

confidence: 99%

Section: In Vitro Non-covalent Hsa Bindingmentioning

confidence: 99%

Simple bioconjugate chemistry serves great clinical advances: albumin as a versatile platform for diagnosis and precision therapy

2016

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“…TACs were derived by drawing ROIs in 99m Tc-window and 131 I-window, respectively. The 3D images of 99m Tc, 131 I and fusion were obtained at different time points 39 40 41 42 .…”

Section: Methodsmentioning

confidence: 99%

Simultaneous SPECT imaging of multi-targets to assist in identifying hepatic lesions

Guo

Gao

Zhang

et al. 2016

Sci Rep

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Molecular imaging technique is an attractive tool to detect liver disease at early stage. This study aims to develop a simultaneous dual-isotope single photon emission computed tomography (SPECT)/CT imaging method to assist diagnosis of hepatic tumor and liver fibrosis. Animal models of liver fibrosis and orthotopic human hepatocellular carcinoma (HCC) were established. The tracers of 131I-NGA and 99mTc-3P-RGD2 were selected to target asialoglycoprotein receptor (ASGPR) on the hepatocytes and integrin αvβ3 receptor in tumor or fibrotic liver, respectively. SPECT imaging and biodistribution study were carried out to verify the feasibility and superiority. As expected, 99mTc-3P-RGD2 had the ability to evaluate liver fibrosis and detect tumor lesions. 131I-NGA showed that it was effective in assessing the anatomy and function of the liver. In synchronized dual-isotope SPECT/CT imaging, clear fusion images can be got within 30 minutes for diagnosing liver fibrosis and liver cancer. This new developed imaging approach enables the acquisition of different physiological information for diagnosing liver fibrosis, liver cancer and evaluating residual functional liver volume simultaneously. So synchronized dual-isotope SPECT/CT imaging with 99mTc-3P-RGD2 and 131I-NGA is an effective approach to detect liver disease, especially liver fibrosis and liver cancer.

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“…However, because of crosstalk between energy spectra and scatter, non-trivial correction methods must be applied, and the energy resolution of scanners is continuously sought to improve this outcome 166,167 . Despite this limitation, dual-tracer SPECT imaging is feasible using 201 Tl or 111 In in healthy volunteers and in diverse disease settings, and including brain imaging, cardiac imaging and cancer imaging 166,[168][169][170][171] . Improved scanner technology 172 and kinetic analysis also promulgate simultaneous dual-isotope imaging in PET, as demonstrated for single-scan dual-tracer (staggered injection of FDG and FLT; 120 min of scan time) studies in patients with primary brain tumours 173 .…”

Section: Imaging Physiology In Patientsmentioning

confidence: 99%

Multiplexed imaging for diagnosis and therapy

et al. 2017

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Complex molecular and metabolic phenotypes depict cancers as a constellation of different diseases with common themes. Precision imaging of such phenotypes requires flexible and tuneable modalities capable of identifying phenotypic fingerprints by using a restricted number of parameters whilst ensuring sensitivity to dynamic biological regulation. Common phenotypes can be detected by in vivo imaging technologies, and effectively define the emerging standards for disease classification and patient stratification in radiology. However, for the imaging data to accurately represent a complex fingerprint, the individual imaging parameters need to be measured and analysed in relation to their wider spatial and molecular context. In this respect, targeted palettes of molecular imaging probes facilitate the detection of heterogeneity in oncogene-driven alterations and their response to treatment, and lead to the expansion of rational-design elements for the combination of imaging experiments. In this Review, we evaluate criteria for conducting multiplexed imaging, and discuss its opportunities for improving patient diagnosis and the monitoring of therapy.

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Simultaneous dual-isotope SPECT/CT with 99mTc- and 111In-labelled albumin microspheres in treatment planning for SIRT

Cited by 10 publications

References 14 publications

Simple bioconjugate chemistry serves great clinical advances: albumin as a versatile platform for diagnosis and precision therapy

Simple bioconjugate chemistry serves great clinical advances: albumin as a versatile platform for diagnosis and precision therapy

Simultaneous SPECT imaging of multi-targets to assist in identifying hepatic lesions

Multiplexed imaging for diagnosis and therapy

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