2013
DOI: 10.1007/s00330-013-2916-9
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Simultaneous dual-isotope SPECT/CT with 99mTc- and 111In-labelled albumin microspheres in treatment planning for SIRT

Abstract: • Simultaneous dual-isotope SPECT/CT with (111) In- and (99m) Tc-labelled albumin microspheres is feasible. • Differentiation of two microsphere fractions after transarterial injection is possible. • The origin of an extra-hepatic microsphere deposition can be correlated to the corresponding artery. • This technique could reduce the setup time for selective internal radiation treatment.

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Cited by 10 publications
(7 citation statements)
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“…Representative HSA drugs based on in vitro conjugation: (a) 111 In-labeled HSA for single-photon emission computed tomography (SPECT); 51 (b) Gd-labeled HSA for magnetic resonance imaging (MRI); 52 (c) 68 Ga-labeled HSA for positron emission tomography (PET); 53 (d) doxorubicin HSA conjugates for cancer chemotherapy with less side effect; 54 (e) 18 F-labeled HSA conjugates for PET; 44 (f) CysCOOH HSA conjugates for photothermal therapy; 55 (g) 3,5-diiodo-thyronine HSA conjugates for antibody production in animals; 56 (h) exendin-4 peptide HSA conjugates for the treatment of type 2 diabetes. 57 …”
Section: Figmentioning
confidence: 99%
See 1 more Smart Citation
“…Representative HSA drugs based on in vitro conjugation: (a) 111 In-labeled HSA for single-photon emission computed tomography (SPECT); 51 (b) Gd-labeled HSA for magnetic resonance imaging (MRI); 52 (c) 68 Ga-labeled HSA for positron emission tomography (PET); 53 (d) doxorubicin HSA conjugates for cancer chemotherapy with less side effect; 54 (e) 18 F-labeled HSA conjugates for PET; 44 (f) CysCOOH HSA conjugates for photothermal therapy; 55 (g) 3,5-diiodo-thyronine HSA conjugates for antibody production in animals; 56 (h) exendin-4 peptide HSA conjugates for the treatment of type 2 diabetes. 57 …”
Section: Figmentioning
confidence: 99%
“…6A and B) have been widely used in clinical diagnosis, especially for lung perfusion and for detecting gastrointestinal bleeding by SPECT. 20,51,[81][82][83] To form this self-assembled capsule, firstly the intramolecular disulfide bonds of HSA are partially reduced by using glutathione (GSH) to give free sulfhydryl groups. Then, the pretreated HSA/ water solution is mixed with small drugs in triaryl butyl alcohol (TBA).…”
Section: In Vitro Non-covalent Hsa Bindingmentioning
confidence: 99%
“…TACs were derived by drawing ROIs in 99m Tc-window and 131 I-window, respectively. The 3D images of 99m Tc, 131 I and fusion were obtained at different time points 39 40 41 42 .…”
Section: Methodsmentioning
confidence: 99%
“…However, because of crosstalk between energy spectra and scatter, non-trivial correction methods must be applied, and the energy resolution of scanners is continuously sought to improve this outcome 166,167 . Despite this limitation, dual-tracer SPECT imaging is feasible using 201 Tl or 111 In in healthy volunteers and in diverse disease settings, and including brain imaging, cardiac imaging and cancer imaging 166,[168][169][170][171] . Improved scanner technology 172 and kinetic analysis also promulgate simultaneous dual-isotope imaging in PET, as demonstrated for single-scan dual-tracer (staggered injection of FDG and FLT; 120 min of scan time) studies in patients with primary brain tumours 173 .…”
Section: Imaging Physiology In Patientsmentioning
confidence: 99%