Simultaneous Determinations of the Total Volume of Red Blood Cells by Use of Carbon Monoxide and Chromium51 IN HEALTHY AND DISEASED HUMAN SUBJECTS1

Nomof, Norman; Hopper, James; Em, Brown; Scott, Kenneth G.; Wennesland, Reidar

doi:10.1172/jci103015

Cited by 40 publications

(18 citation statements)

References 19 publications

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“…The remaining unbound isotope was removed with two saline washings. Washing the cells does not seem to seriously affect subsequent in vivo red cell disappearance rates, as the experience of others has shown (16 (25). In fact, the cardiovascular responses of this group to hypoxia are in certain respects different from those seen in non-Indian, high altitude populations that have been established in more recent times (26).…”

Section: Discussionmentioning

confidence: 73%

The red cell mass-arterial oxygen relationship in normal man

Weil¹,

Jamieson²,

Brown³

et al. 1968

J. Clin. Invest.

163

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A B S T R A C T The normal relationship between red cell mass measured, with 51chromium-labeled red cells, and arterial oxygen saturation (Sao2) over the range from 97.3 to 83.4% was examined by studying 73 normal men residing at sea level and altitudes of 1600 and 3100 m. A simple, linear relationship between Sao2 and red cell mass was found over the entire range (r =-0.7524, P < 0.001). In contrast, a correlation between red cell mass and arterial 02 tension was found only over the lower half of the range of 02 tensions where Sao2 was also decreased (r = -0.7731, P < 0.005).

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Section: Discussionmentioning

confidence: 73%

The red cell mass-arterial oxygen relationship in normal man

Weil¹,

Jamieson²,

Brown³

et al. 1968

J. Clin. Invest.

163

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“…The volume of cells (Vrbc) was measured by a modification of the Cr' method of Sterling and Gray (24) which we have described elsewhere (25) and which will be analyzed in a forthcoming publication (26). Essentially, the procedure was as follows: 1) About 15 ml.…”

Section: Subjectsmentioning

confidence: 99%

“…The demonstration by Kjellberg, Rudhe and Sjdstrand (21) of large differences between the blood volumes of athletically trained and untrained persons requires re-examination. The carbon monoxide method which they used is particularly unsuitable for this problem, since 15 per cent of the test dose of gas leaves the blood during the measurement and goes mostly to muscle pigments (25,27 2. Regression equations were derived, expressing the relations of the volumes to body weight and height and to combinations of these measures.…”

Section: Dicussionmentioning

confidence: 99%

“…We have used the Cr51 method of Sterling and Gray (24,25) to measure Vrbc and, indirectly from the hematocrit, Vwb and Vpl in 201 healthy prison inmates. Trivariate regression equations have been derived for the plane surfaces which relate the volumes to height and weight and a graphic system for their rapid application to practical problems has been developed.…”

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confidence: 99%

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RED CELL, PLASMA AND BLOOD VOLUME IN HEALTHY MEN MEASURED BY RADIOCHROMIUM (Cr51) CELL TAGGING AND HEMATOCRIT: INFLUENCE OF AGE, SOMATOTYPE AND HABITS OF PHYSICAL ACTIVITY ON THE VARIANCE AFTER REGRESSION OF VOLUMES TO HEIGHT AND WEIGHT COMBINED*

Wennesland¹,

Em²,

Hopper³

et al. 1959

J. Clin. Invest.

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193

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“…The determination of total circulating hemoglobin from CO dilution assumes that CO dilution measures circulating red cell volume. Red cell volumes measured by the CO method are 6-16% higher than that measured by the use of 51Cr (30,40). This has been attributed to the binding of some of the administered CO by extravascular substances, chiefly myoglobin.…”

Section: Co Production and Mean Red Cell Life Span (Mls)mentioning

confidence: 86%

Endogenous production of carbon monoxide in normal and erythroblastotic newborn infants

Maisels¹,

Pathak²,

Nelson³

et al. 1971

J. Clin. Invest.

129

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A B S T R A C T The endogenous production of carbon monoxide (Vco) in newborn infants was measured by serial determinations of blood carboxyhemoglobin during rebreathing in a closed system. Mean Vco in nine full-term infants was 13.7 zt3.6 Al CO/kg per hr (SD), and in four erythroblastotic infants Vco ranged from 37 to 154 sl CO/kg per hr preceding exchange transfusion. Mean red cell life-span (MLS) and total bilirubin production were calculated from Yco. MLS in normal newborns was 88 :1:15 days (SD), and bilirubin production was 8.5 =12.3 mg/kg per 24 hr. This is more than twice the amount of bilirubin normally produced in the adult per kilogram of body weight. Normal infants achieved a net excretion of bilirubin of at least 5.6 4-2.3 mg/kg per 24 hr (SD) as calculated from the bilirubin production and the measured rise in serum bilirubin concentration.The measurement of Vco should prove valuable in the study of red blood cell survival and bilirubin metabolism in the newborn infant. INTRODUCTIONThe recent studies of Coburn and coworkers (1-3) have confirmed the original observations by Sjbstrand (4-6) that carbon monoxide (CO) is endogenously produced in normal man, and that approximately 1 mole of CO is produced per mole of heme catabolized (2).

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Simultaneous Determinations of the Total Volume of Red Blood Cells by Use of Carbon Monoxide and Chromium51 IN HEALTHY AND DISEASED HUMAN SUBJECTS1

Cited by 40 publications

References 19 publications

The red cell mass-arterial oxygen relationship in normal man

The red cell mass-arterial oxygen relationship in normal man

RED CELL, PLASMA AND BLOOD VOLUME IN HEALTHY MEN MEASURED BY RADIOCHROMIUM (Cr51) CELL TAGGING AND HEMATOCRIT: INFLUENCE OF AGE, SOMATOTYPE AND HABITS OF PHYSICAL ACTIVITY ON THE VARIANCE AFTER REGRESSION OF VOLUMES TO HEIGHT AND WEIGHT COMBINED*

Endogenous production of carbon monoxide in normal and erythroblastotic newborn infants

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