“…Therefore, it is essential to develop the sensitive, reliable, and simple approaches for the determination of V B12 in pharmaceuticals, foods and biological samples. The proposed methods for the quantitative determination of V B12 include high‐performance liquid chromatography (HPLC) , UV‐vis spectrophotometry , fluorescence spectrometry , chemiluminescence detection , electrochemical measurement , capillary electrophoresis inductively coupled plasma mass spectrometry (CE‐ICP‐MS) , radioassay , enzyme‐linked immunosorbent assay (ELISA) , and so on. As well known, several advantages, such as low cost, easy operation, good stability and high sensitivity, are involved in electrochemical analysis .…”