Simultaneous Determination of Urinary Androstanediol and Testosterone as an Evaluation of Human Androgenicity

Mauvais-Jarvis, P; Charransol, G.; Bobas-Masson, F.

doi:10.1210/jcem-36-3-452

Cited by 101 publications

(22 citation statements)

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“…However, in the complete androgen resistance syndrome (testicular feminization), despite normal testosterone levels, the formation of 3a-diol glucuironide was reduced. Testosterone was a better precursor of urinary 3a-diol when given through skin than when given directly inlto the circulation (26).…”

Section: Discussionmentioning

confidence: 94%

3 alpha, 17 beta-androstanediol glucuronide in plasma. A marker of androgen action in idiopathic hirsutism.

Horton¹,

Hawks²,

Løbo³

1982

J. Clin. Invest.

180

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A B S T R A C T Biologically active androgens and peripheral androgen metabolites in plasma were measured in 25 women with idiopathic hirsutism (IH). Plasma testosterone was not significantly elevated. Free testosterone however was increased although the elevation was not impressive (10.9±6.6 SD vs. 3.3±1.5 ng/dl) and one-fourth of the cases had normal unbound testosterone. Dihydrotestosterone (DHT) values were elevated (23.5±14 vs. 12.5±3.59) but again over half of the values were within the normal range. In our series of mild to moderate cases, 3a-diol was not at all discriminatory. However, plasma 3a-diol glucuronide was markedly increased (604±376 vs. 40±10 ng/dl), and elevated in all but one mild case. Previous studies document that DHT is the important androgen in skin and formation of DHT and 3at-diol is markedly increased in vitro in IH. Since 3a-diol glucuronide is derived largely from extrasplanchnic events, f3-glucuronidase is present in skin, and androgen stimulates formation of the enzyme in extrasplanchnic tissue, we conclude that 3a-diol glucuronide is a marker of peripheral androgen action and markedly elevated in IH.

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Section: Discussionmentioning

confidence: 94%

3 alpha, 17 beta-androstanediol glucuronide in plasma. A marker of androgen action in idiopathic hirsutism.

Horton¹,

Hawks²,

Løbo³

1982

J. Clin. Invest.

180

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“…metabolism through DHT in the skin (Mauvais-Jarvis, Kutten & Mowszowicz, 1980). 5a-Androstane-3a,17ß-diol may, therefore, be considered to be a biochemical marker of peripheral hirsutism as already suggested in previous reports (Mauvais-Jarvis, Charransol & Bobas-Masson, 1973;Toscano, Sciarra, Adamo, Petrangeli, Foli, Caiola & Conti, 1982).…”

Section: Discussionmentioning

confidence: 71%

Is hirsutism an evolving syndrome?

Toscano¹,

Adamo²,

Caiola³

et al. 1983

Journal of Endocrinology

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The possibility that hirsutism is an evolving syndrome rather than a static condition involving only one gland has been considered. To assess this proposal 60 untreated hirsute patients aged 12-32 years were divided into five groups according to the duration of the hirsutism (less than 1, 1-2, 2-3, 3-5 and greater than 5 years). Peripheral plasma concentrations of LH and FSH, androstenedione, dehydroepiandrosterone sulphate, testosterone, 5 alpha-dihydrotestosterone, 5 alpha-androstane-3 alpha, 17 beta-diol, 5 alpha-androstane-3 beta, 17 beta-diol, cortisol, oestradiol-17 beta and oestrone were determined by radioimmunoassay. When the values obtained were compared with those from normal menstruating women, the results showed that in group I there was a significant increase only in the mean plasma 5 alpha-androstane-3 alpha, 17 beta-diol concentration. The mean concentration of this steroid was also raised in all other groups. In groups II and III mean basal levels of plasma dehydroepiandrosterone sulphate were also significantly increased and showed a marked increase after ACTH stimulation (1 mg tetracosactide acetate, i.m.) as did the concentrations of androstenedione and 17 alpha-hydroxyprogesterone. Finally, in groups IV and V, a significant increase in mean plasma concentrations of LH, androstenedione, oestrone and testosterone was found in the basal condition. The clinical picture also became gradually more severe from group I to group V. These data suggest that hirsutism could be an evolving syndrome progressively involving peripheral androgen metabolism, the adrenal gland and finally the ovary possibly through alterations of hypothalamic-pituitary function.

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“…Ceux de Lagoguey et al, sur le rythme nycth~m~ral de GT et GEPIT, [20], ont montr~ des variations d'~limination de ces st~ro~des pouvant atteindre 50% au cours de l'ann~e. Les valeurs de GT sont bien document~es dans la litt~rature internationale [7,10,11,19,23,25, 33] et bien connues des endocrinologues contrairement celles de GEPIT. La moyenne (+ 2 ~cart-types) pour GT se situe, chez rhomme, 109,4 • 43,1 /tg/24h soit 380 _+ 149 nmol/24h.…”

Section: Discussionunclassified