Simultaneous determination of seven nitroimidazole residues in meat by using HPLC-UV detection with solid-phase extraction

Development and validation of an ionic chromatography method for the determination of nitrate, nitrite and chloride in meat

“…Several types of chromatographic techniques, such as GC-NPD or FID (Wang, 2001), HPLC-UV (Eggers & Cattle, 1986;Jobgen et al, 2007;Sun et al, 2007), IC-UV/VIS or conductivity detector (Siu &Henshall, 1998), andGC-MS (Calbiani et al, 2007;Zeleny et al, 2009;Di Stefano et al, 2012) are currently used for the analysis of the studied compounds. Among all, Ion Chromatography is a fast and automatic method used to obtain trustworthy results,.…”

Development and validation of a rapid method for the determination and confirmation of 10 nitroimidazoles in animal plasma using liquid chromatography tandem mass spectrometry

“…Therefore, plasma, retina and eggs have been recommended as target matrices for the residue control of nitroimidazoles [11,12]. Current methods that are used for the analysis of these compounds are limited to the analysis of at most seven nitroimidazole compounds [1,13], but the majority analyse for fewer [9,10,14,15,[17][18][19][20][21][22]. These methods use varied extraction protocols including the use of acetonitrile [13] or ethyl acetate [9,16] as extraction solvent.…”

“…Current methods that are used for the analysis of these compounds are limited to the analysis of at most seven nitroimidazole compounds [1,13], but the majority analyse for fewer [9,10,14,15,[17][18][19][20][21][22]. These methods use varied extraction protocols including the use of acetonitrile [13] or ethyl acetate [9,16] as extraction solvent. In some cases the samples were extracted using a buffer of NaCl/KH 2 PO 4 with protease and adjusting the pH to 3 with 25% HCl [7,10].…”

“…[1,7,[9][10][11][12]14,15] and methods that do not employ SPE [13,19,20] were not used to analyse plasma. Various techniques have been used for the analysis of these compounds such as HPLC-UV [15] and GC-MS/MS [10].…”

“…Various techniques have been used for the analysis of these compounds such as HPLC-UV [15] and GC-MS/MS [10]. The use of GC-MS/MS limits the number of analytes that can be analysed due to problems arising from derivatisation, due to the fact that HMMNI and RNZ form the same derivatisation products [7,13]. Presently more methods are now being developed for this analysis by LC-MS/MS which allow for a greater number of analytes being analysed [1,7,9,13,16].…”