Simultaneous Determination of Plasma Volume and Transcapillary Escape Rate With 131 I‐labelled Albumin and T‐1824 in the Newborn

Parving, Hans‐Henrik; Klebe, Joachim G.; Ingomar, C. J.

doi:10.1111/j.1651-2227.1973.tb08100.x

Cited by 40 publications

(20 citation statements)

References 16 publications

(11 reference statements)

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“…The increased capillary hydrostatic pressure plus an elevated left atrial pressure can deter mine an increase in interstitial and alveolar lung fluid (21), that may further decrease CL. This is especially true in the newborn in whom capil lary permeability may be increased (17) and oncotic pressure frequently is low.…”

Section: Discussionmentioning

confidence: 99%

Lung Compliance in Newborns with Patent Ductus Arteriosus before and after Surgical Ligation

Gerhardt

Bancalari²

1980

Neonatology

105

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Pressure volume curves of the lungs were determined in 10 premature infants (mean gestational age 31.4 weeks, mean birth weight 1,260 g) before and after surgical ligation of a patent ductus arteriosus (PDA). 7 infants who had low compliance initially showed a significant improvement in lung compliance after surgery, while 3 infants whose compliance was close to normal before surgery had a decrease after ligation. In conclusion, a PDA with left to right shunt is frequently associated with a decrease in lung compliance that improves after ligation. Measurement of lung compliance in infants with PDA can be helpful in predicting the degree of improvement in lung function that may result from the closure of the ductus.

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Section: Discussionmentioning

confidence: 99%

Lung Compliance in Newborns with Patent Ductus Arteriosus before and after Surgical Ligation

Gerhardt

Bancalari²

1980

Neonatology

105

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“…The duration of the decrease in TEWL is short, probably because of the rapid redistri bution of albumin [18,19]. The transcapil lary escape rate for albumin is higher in new born infants than in adults [18].…”

Section: Discussionmentioning

confidence: 99%

Effects of Human Albumin Infusion on Transepidermal Water Loss in Newborn Infants

Hammarlund¹,

Hellsing²,

Sedin³

et al. 1984

Neonatology

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A study was made to determine whether the high transepidermal water loss in preterm newborn infants is affected by infusion of human albumin. In 7 preterm infants, born after 25–30 weeks of gestation, 0.5 g of human albumin per kilogram body weight (b.w.) was infused through an umbilical artery catheter in 6 h on the 1st day after birth. In 2 other infants, born after 28 completed weeks of gestation, human albumin in an amount of 1.0 g/kg body weight was infused. The plasma albumin concentration increased significantly from a pre-infusion value of 27.1 to 29.5 g/l after 4 h of infusion. Simultaneously the transepidermal water loss decreased from 26.6 to 23.5 g/(m²·h); this difference was also significant. Within 2 h after the end of the albumin infusion, both the plasma albumin concentration and the transepidermal water loss had returned to levels that were not significantly different from the pre-infusion values. Plasma osmolality and sodium concentration did not alter during the infusion, nor did arterial blood pressure.

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“…Concentrations of antipyrine in plasma were determined in triplicate using a microadaptation of Mendelsohn and Levin's technique (3). Concentration of T-1824 in plasma were determined in duplicate by a double-wavelength technique (4)(5)(6).…”

Section: Materials a N D Methodsmentioning

confidence: 99%

Dilution Kinetics of Chemicals Used for Estimation of Water Content of Body Compartments in Perinatal Medicine

et al. 1989

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PAH, p-aminohippurateNumerous studies of perinatal physiology, metabolism, nutrition, and pathologic conditions require estimation of the fluid content of various body compartments. As direct volumetric determinations are not possible in vivo, less direct methods must be relied upon to obtain an acceptable estimate. The most commonly used techniques involve a principle developed by Fick. Fick's principle states that the fluid content (V) of a given space may be calculated following the administration of a dye or chemical into that space if the exact amount (Q) of substance injected and its concentration (C) in the fluid of the space are Rece~ved August 15, 1988; accepted November 22, 1988 known, or V = Q/C. The dye or chemical must have five main properties: It must I ) be harmless to the organism; 2) be easily measurable; 3) diffuse evenly and within a predictable period of time throughout its vol of distribution; 4) have no effect on fluxes of fluids across membranes; and 5 ) neither be metabolized nor leave the space for which the vol is being measured for the duration of the study. This last requirement is seldom met. If, however, the decrease in dye concentration with time follows a straight line, extrapolation of that line to time 0 (y-intercept or Co) still allows a vol determination to be made, or V = Q/Co. In that case, the rate at which the substance escapes from its vol of distribution, be it by metabolism or excretion, may be also calculated (slope of the concentration versus time line).In cases where all four criteria are met, the marker diffuses as soon as it is administered to reach an even concentration throughout its vol of distribution. In cases where the fourth criterion is not met, two phenomena occur simultaneously as soon as the marker is administered. First, the marker diffuses to reach an even concentration throughout its vol of distribution; second it is being cleared from its assigned space. To interpret the data correctly, it is important to determine at what point in time equilibration is complete and the behavior of the marker concentration thereafter, i.e. the kinetics of the marker. Yet kinetic data have often been disregarded or remained buried in the investigators' laboratory data books and are scarce in the relevant literature. Also, in human perinatal medicine, there are ethical and practical limitations on the number and vol of body fluid samples that may be obtained. In this report, we have made use of the baboon (Papio cynocephalus), whose fetoplacentouterine unit and neonatal physiology and metabolism are very similar to those of Homo sapiens, to determine the kinetics of six markers: PAH (amniotic fluid vol), inulin (amniotic fluid vol), antipyrine (total body water), H2'" (total body water), bromide (extracellular water) and T-1824 (plasma vol). From these kinetics, precise recommendations may be made regarding optimal time and method of amniotic fluid or blood sampling. MATERIALS A N D METHODSPAIf and inulin dilution. The kinetics of PAH and inulin dilution in amniotic f...

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Simultaneous Determination of Plasma Volume and Transcapillary Escape Rate With 131 I‐labelled Albumin and T‐1824 in the Newborn

Cited by 40 publications

References 16 publications

Lung Compliance in Newborns with Patent Ductus Arteriosus before and after Surgical Ligation

Lung Compliance in Newborns with Patent Ductus Arteriosus before and after Surgical Ligation

Effects of Human Albumin Infusion on Transepidermal Water Loss in Newborn Infants

Dilution Kinetics of Chemicals Used for Estimation of Water Content of Body Compartments in Perinatal Medicine

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