Simultaneous determination of montelukast and loratadine by HPLC and derivative spectrophotometric methods

Radhakrishna, T; Narasaraju, A.; Ramakrishna, M.; Satyanarayana, A.

doi:10.1016/s0731-7085(02)00650-7

Cited by 82 publications

(52 citation statements)

References 12 publications

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“…Literature review indicates that few analytical methods like spectrophotometric [3], HPLC [4][5][6][7] and LC-MS [8] have been reported for the quantification of montelukast with other drugs. Acebrophylline ( Fig.1) chemically is 4-[2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol; 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetic acid.…”

Section: Montelukast (Fig 1) Chemically Is (1-[[[1r-1-[3-(1e)-2-(7-cmentioning

confidence: 99%

RP-HPLC-PDA Method for Simultaneous Quantification of Montelukast, Acebrophylline and Desloratadine Tablets

Mamatha¹,

Devanna²

2018

Asian J. Chem.

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A simple, fast, accurate and specific RP-HPLC-PDA method has been developed for the simultaneous quantification of montelukast, acebrophylline and desloratadine in bulk and tablet dosage form. The chromatographic separation was performed on a reverse phase BDS C8 Column (150 × 4.6mm, 5 µm particle size) consisting mobile phase of potassium hydrogen ortho-phosphate buffer:acetonitrile (40:60 v/v), with a flow rate 1 mL/min, temperature 30 ºC and UV detection wavelength 280 nm. The retention times of montelukast, acebrophylline and desloratadine were observed as 2.04, 2.68 and 3.77 min, respectively. The developed method was validated by validation parameters such as linearity, range, accuracy, precision and robustness. The results obtained for validation parameters are within the limits as per ICH guidelines. The linearity of the drugs were obtained in the range of 5-30 ppm for montelukast, 100-600 ppm acebrophylline and 2.5-15 ppm for desloratadine. % RSD from precision studies were 0.4, 0.1 and 1.0 mean percentage recovery from accuracy studies were found to be 98.47, 98.71 and 100.11 for montelukast, acebrophylline and desloratadine respeactively. Limit of detection values were found as 0.01, 0.32 and 0.01 for montelukast, acebrophylline and desloratadine, respectively. Limit of quantification values were found as 0.03, 0.98 and 0.04 montelukast, acebrophylline and desloratadine, respectively. The method designed and validated can be successfully used for the regular quantification of montelukast, acebrophylline and desloratadine in tablet and bulk forms.

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Section: Montelukast (Fig 1) Chemically Is (1-[[[1r-1-[3-(1e)-2-(7-cmentioning

confidence: 99%

RP-HPLC-PDA Method for Simultaneous Quantification of Montelukast, Acebrophylline and Desloratadine Tablets

Mamatha¹,

Devanna²

2018

Asian J. Chem.

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“…Figure 2. Structure of fexofenadine hydrochride During literature survey it was found that, various HPLC methods have been estimated for the determination of montelukast sodium [4][5][6][7] and fexofenadine hydrochloride [8][9][10][11] in combination with other drugs but no RP-HPLC method has been determined till date. Hence an attempt has been made to develop and validate a simple, economic, rapid and accurate method.…”

Section: -[2-(1-hydroxy-1-methylethyl) Phenyl] Propyl -Sulfanylmethymentioning

confidence: 99%

Development and Validation of RP-HPLC Method for Estimation of Montelukast Sodium and Fexofenadine Hydrochloride in Pharmaceutical Preparations

2013

Chem Sci Trans

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Abstract:Objective of the present work was to develop a simple and precise HPLC method for montelukast sodium (MON) and fexofenadine hydrochloride (FEX). The combination is used as anti-asthmatic, anti-allergic and is available in tablet dosage form. HPLC separation was achieved with a hypersil ODS-C18 (5 µ, 250 mm x 4.6 mm, i.d.) as a stationary phase and methanol: acetonitrile: 1% trifluoroacetic acid (80:10:10 v/v/v) as eluent, at a flow rate of 1.0 mL/min, UV detection was performed at 210 nm. The retention time of montelukast sodium and fexofenadine hydrochloride were found to be 5.1 and 3.7 min respectively. Results of analysis were validated by recovery studies. Result of studies showed that the proposed RP-HPLC method is simple, rapid, accurate and precise which can be used for the routine determination of montelukast sodium and fexofenadine hydrochloride in bulk and its pharmaceutical dosage form.

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“…In oral dosage form, each packet contains Montelukast Sodium equivalent to 10 mg of Montelukast. Several analytical methods have been reported for determination of Montelukast including derivative spectroscopic 4 , by colorimetry 5 , by flouorimetry 6 , by TLC 7 , by HPTLC 8 , by simultaneous UV determination in combination drug formulation 9 , by voltametry 10 , by high performance liquid chromatography (HPLC) 11 and by LCMS 12 . To our knowledge, there is no simple and accurate UV spectrophotometric method for quantitative determination of Montelukast Sodium in its bulk and in its tablet dosage forms.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2015

IJPSR

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Montelukast sodium is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies 1-2 . Montelukast comes as a tablet, a chewable tablet, and granules to take by mouth 3 . Montelukast is usually taken once a day with or without food 3 . The present study describes a simple, accurate reproducible and precise uv spectrophotometric method for the estimation of Montelukast Sodium in bulk and in tablet dosage form. The absorbance maxima (λmax) for Montelukast Sodium were found to be 286.5nm. The method was validated for different parameters such as molar absorptivity, accuracy precision, ruggedness, robustness, detection limit, quantification limit etc, (as per ICH guidelines). The relative standard deviation (RSD) in case of, accuracy precision, ruggedness, robustness was less than 2.0% proving that method was highly accurate, precise and robust. This method can be used for determination of Montelukast Sodium in pharmaceutical formulations without interference of the excipients.

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Simultaneous determination of montelukast and loratadine by HPLC and derivative spectrophotometric methods

Cited by 82 publications

References 12 publications

RP-HPLC-PDA Method for Simultaneous Quantification of Montelukast, Acebrophylline and Desloratadine Tablets

RP-HPLC-PDA Method for Simultaneous Quantification of Montelukast, Acebrophylline and Desloratadine Tablets

Development and Validation of RP-HPLC Method for Estimation of Montelukast Sodium and Fexofenadine Hydrochloride in Pharmaceutical Preparations

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