Simultaneous determination of methanol, ethanol, acetone, isopropanol and ethylene glycol in plasma by gas chromatography

Cheung, Shu-Tong; Lin, Wen-Nuel

doi:10.1016/0378-4347(87)80049-x

Cited by 28 publications

(8 citation statements)

References 8 publications

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“…The working period for packed column is also known to be comparatively shorter than with capillary column. However, notwithstanding the use of packed column or capillary column, many current methods for determination of methanol still suggest pre-treatment of samples with solid-phase extraction (Pereira et al, 1999), head-space equilibrium (Davoli et al, 1986;Cheung and Lin, 1987), solvent extraction (Pollack and Kawagoa, 1991) and/or distillation (Blanch et al, 1992). These pre-treatments are the most time-consuming steps and sources of frequent errors.…”

Section: Article In Pressmentioning

confidence: 98%

A rapid and accurate method for determination of methanol in alcoholic beverage by direct injection capillary gas chromatography

Wang

Wang²,

Choong³

2004

Journal of Food Composition and Analysis

109

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Section: Article In Pressmentioning

confidence: 98%

A rapid and accurate method for determination of methanol in alcoholic beverage by direct injection capillary gas chromatography

Wang

Wang²,

Choong³

2004

Journal of Food Composition and Analysis

109

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“…[1][2][3][4][5][6] Methanol is often used as a solvent for the extraction of plant components. A number of methods, including enzymatic, [13][14] colorimetric, [15] gas chromatographic (GC) [16][17][18][19][20] and HPLC [21][22][23][24] techniques, have been reported for the determination of methanol in various matrices. So it must be removed finally from plant extract medicine.…”

Section: Introductionmentioning

confidence: 99%

Determination of Methanol by 4-[N-Methyl,N-(1-naphthylmethyl)]-amino-4-oxo-butanoic Acid in Presence of 4-Dimethylaminopyridine and 1-Ethyl-3-(3-dimethylaminopropyl) Carbodiimide Hydrochloride as Catalysts

Kuo

Wen

et al. 2003

Analytical Letters

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High performance liquid chromatography (HPLC) with chemically removable derivatizing reagents for the analysis of methanol has been developed. Methanol was derivatized with 4-[N-methyl, N-(1-naphthylmethyl)]-amino-4-oxo-butanoic acid (NAOB), using 4-dimethylaminopyridine (DMAP) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) as activators. NAOB and the activators are chemically removable and can be removed by aqueous base and acid treatment after derivatization to minimize reagent interference in chromatography. The method can simultaneously determine methanol, ethanol and 1-propanol. The proposed HPLC method was validated for linearity, specificity, accuracy and reproducibility. The method was applied to the analysis of methanol spiked in Ipecac fluid extract with a satisfactory recovery (>95%).method to the analysis of other aliphatic alcohols in various fluid extracts is being studied. CONCLUSIONThe proposed method can directly derivatize methanol and primary alcohols to their naphthyl derivative in an alkaloids and water enriched matrix. The method effectively avoids the interferers from reactive amines of alkaloids, such as emetine and cephaeline. In addition, the method was found useful for the derivatization not only of primary alcohols, but also for secondary alcohols. The method is also sensitive, accurate and precise and could be easily applied for the derivatization of various hydroxyl group-containing compounds.

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“…A number of methods have been developed to determine the alcohol concentration in various samples. Methods such as enzymatic 1 and non-enzymatic gas diffusion, 2 amperometric flow-injection analysis, 3 colorimetry using a dehydrogenase-based biosensor 4 and gas chromatography (GC), 5,6 have been well described. Among these methods, a direct GC method coupled with a flame ionization detector and a capillary column is the most widely used techniques for the determination of alcohols in various matrices.…”

Section: Introductionmentioning

confidence: 99%

Liquid Chromatographic Determination of Alcohols in Food and Beverages with Indirect Polarimetric Detection Using a β-Cyclodextrin Mobile Phase

et al. 2002

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An indirect polarimetric detection method for the determination of alcohols has been proposed in liquid chromatography (LC). Optically active mobile-phase additives, such as β-cyclodextrin (β-CD), could be used to visualize optically inactive alcohols in reversed-phase LC. The visualization of alcohols is based on a perturbation of the partition of β-CD caused by the alcohols. The detection limits of the present system at a signal-to-noise ratio of 3 were 0.031, 0.019, 0.018, 0.013, 0.011, 0.008 and 0.008% (v/v) for ethanol, 2-propanol, 1-propanol, 2-methyl-2-propanol, 2-butanol, 2-methyl-1-propanol and 1-butanol, respectively. The method was successfully applied to the determination of ethanol present in food and beverage samples.

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Simultaneous determination of methanol, ethanol, acetone, isopropanol and ethylene glycol in plasma by gas chromatography

Cited by 28 publications

References 8 publications

A rapid and accurate method for determination of methanol in alcoholic beverage by direct injection capillary gas chromatography

A rapid and accurate method for determination of methanol in alcoholic beverage by direct injection capillary gas chromatography

Determination of Methanol by 4-[N-Methyl,N-(1-naphthylmethyl)]-amino-4-oxo-butanoic Acid in Presence of 4-Dimethylaminopyridine and 1-Ethyl-3-(3-dimethylaminopropyl) Carbodiimide Hydrochloride as Catalysts

Liquid Chromatographic Determination of Alcohols in Food and Beverages with Indirect Polarimetric Detection Using a β-Cyclodextrin Mobile Phase

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