Simultaneous Determination of Metamizole, Thiamin and Pyridoxin Using UV-Spectroscopy in Combination with Multivariate Calibration

Chotimah, Chusnul; Sudjadi, Sudjadi; Riyanto, Sugeng; Rohman, Abdul

doi:10.15171/apb.2015.080

Cited by 12 publications

(6 citation statements)

References 15 publications

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“…In standard (M), the maximum absorption is obtained at a wavelength of 263.8 nm, and in samples A1 and A2, it is obtained that the maximum absorption is in the range of wavelengths of 264.4 and 264.2 respectively, and has similarities with the maximum wavelength of the standard. The maximum wavelength absorption of sodium metamizole, at a wavelength of 263 nm in ethanol media, obtained similar results to research from [13] that the maximum wavelength of sodium metamizole was in the range of 260-270 nm. This result follows Determination of BKO levels in Jamu samples was carried out using a UV spectrophotometer.…”

Section: Resultssupporting

confidence: 84%

“…The preparation of working standard solutions and calibration curves for paracetamol and sodium meta-mizole were carried out according to procedures [7,13] with minor modifications. Each standard of Sodium Metamizole (M), Dexamethasone (D), Ibuprofen (I), and Paracetamol (PC) was weighed 10 mg and dissolved in absolute ethanol pro analysis up to 10 mL to obtain a standard solution with a concentration of 1000 ppm.…”

Section: Preparation Of Standard Solutionmentioning

confidence: 99%

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UV-Vis Spektrofotometrisi ile Geleneksel Bitkisel Ürünlerde (Jamu) Tıbbi Kimyasalların Doğrulanması

HUSAIN,

YSRAFİL,

DAUD

et al. 2023

HUJPHARM

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Traditional medicine "Jamu" is becoming very popular used by the community as an alternative treatment that can minimize side effects. However, it is profitable for manufacturers who are not responsible for herbal products by adding medicinal chemicals (BKO) to traditional herbal products. The samples used in this study were samples of traditional herbal medicine coded A1, A2; B1, B2; C1, C2; D1, D2; E1, E2; and F1, F2, which were analyzed qualitatively and quantitatively using thin-layer chromatography (TLC) and UV-Vis spectrophotometry. Based on the results obtained from the analysis using the TLC method, the herbal samples with code A1 A2 had a staining profile, Rf value, and chromatographic peak that were almost the same as the comparison standard for sodium metamizole with levels of 51.99% (A1) and 53.06% (B). the herbal medicine samples with codes B1, B2, and C1, C2 had stain profiles, Rf values, and spectrophotometric chromatography peaks that were almost the same as the comparison standard for paracetamol with paracetamol levels contained in the “Jamu” samples of 81.31% (B1), 81.66% (B2), 89.59% (C1) and 81.62% (C2). The results obtained from this study can be concluded that the samples of traditional herbal products with codes A1 and A2 contain sodium metamizole with levels of >50%. Samples of traditional herbal products B1, B2, C1, and C2 contain paracetamol with paracetamol levels contained > 50%, while the traditional herbal medicine samples with codes D1, D2, E1, E2, F1, and F2 have been identified as containing no medicinal chemicals in the traditional herbal medicine samples.

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Section: Resultssupporting

confidence: 84%

Section: Preparation Of Standard Solutionmentioning

confidence: 99%

UV-Vis Spektrofotometrisi ile Geleneksel Bitkisel Ürünlerde (Jamu) Tıbbi Kimyasalların Doğrulanması

HUSAIN,

YSRAFİL,

DAUD

et al. 2023

HUJPHARM

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“…A spectrophotometric methods were suggested for estimating B1 and Sulphite such as determination of B1 by precipitation of sulphur as barium sulphate [8], or produced a brown color which resulted from the reaction between B1 and 7-chloro-4-nitrobenzoxadiazole [9] measured at 434 nm, also B1 reacted with 1,2-naphthoquine-4-sulphonate and measured at 487 nm [10]. Various technique have been used in the determination of B1 using fourier transform infrared [11], other method based on coupling between multivariate calibration of partial least square and spectrophotometry [12], or determination B1 and B6 in Injection formulation [13]. Other spectrophotometric method estimating B1 Spectiphotometically in pharmaceutical forms, tablet and capsule dosage [14].…”

Section: Introductionmentioning

confidence: 99%

Estimation of thiamine hydrochloride and sulphite using charge transfer complex reaction

Saleem¹

2021

sjpas

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A new spectrophotometric method is used for estimating Thiamine hydrochloride in its pure form and pharmaceutical formulations, the present method depends on the reaction between Thiamine hydrochloride and chrome azurol S to form a red complex which exhibit maximum absorption at 510 nm, the addition of Sulphite to the resulted red complex is bleaching it and this step was used for the determination of Sulphite which is considered an attacker of Thiamine hydrochloride, therefore, this method was developed for determination of Thiamine hydrochloride in presence of Sulphite. The linearity of the proposed method was obeyed Beer’s law from 2 to 48 and 0.04 to 2.4 ppm for Thiamine hydrochloride and Sulphite respectively. Also, the method sensitivity was measured by molar absorptivity values 5.9×104 l.mol-1.cm-1 and 1.68×104 l.mol-1.cm-1 for Thiamine hydrochloride and Sulphite respectively. The present method accuracy (average recovery) 100.06% and 100.04% the precision (RSD) of the method is ±0.98 - ±1.27% and ±0.76 - ±1.47 of Thiamine hydrochloride and Sulphite respectively. This method was applied for the estimation of B1 and SO32- in pharmaceutical preparations and various water samples respectively.

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“…A new appearance of metamizole, especially in the United States, is associated with its growing application as an adulterant in illicit drugs . For instance, metamizole has recently been detected in illegal fentanyl samples (which itself is often used to cut heroin) by different chromatography‐based analyses .…”

mentioning

confidence: 99%

“…[44][45][46] A new appearance of metamizole, especially in the United States, is associated with its growing application as an adulterant in illicit drugs. 47,48 For instance, metamizole has recently been detected in illegal fentanyl samples (which itself is often used to cut heroin) by different chromatography-based analyses. 49 It has been known for quite some time that metamizole is also used as an adulterant to cut cocaine for street-level consumption.…”

mentioning

confidence: 99%

Metamizole (Dipyrone) and the Liver: A Review of the Literature

Lutz

2019

The Journal of Clinical Pharma

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Metamizole, also known as dipyrone, was introduced to the market nearly a century ago. Due to its excellent analgesic, antipyretic, and spasmolytic properties combined with its mostly favorable gastrointestinal tolerability, the drug was extensively applied worldwide during the first decades after its market introduction. Although rare, agranulocytosis is a well‐known adverse event of metamizole and led to its withdrawal from the market in a number of countries beginning in the 1960s. Nevertheless, metamizole is still a frequently used drug worldwide either legally (by prescription in some countries, over the counter in other countries) or without official approval (especially by immigrants knowing the drug from their home countries) or even illegally (due to its growing application as an adulterant in illicit drugs). Metamizole undergoes extensive metabolism in the liver and cases of potential metamizole‐associated hepatotoxicity have been described. Here, the literature is extensively reviewed for the first time regarding hepatic effects associated with the use of metamizole.

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Simultaneous Determination of Metamizole, Thiamin and Pyridoxin Using UV-Spectroscopy in Combination with Multivariate Calibration

Cited by 12 publications

References 15 publications

UV-Vis Spektrofotometrisi ile Geleneksel Bitkisel Ürünlerde (Jamu) Tıbbi Kimyasalların Doğrulanması

UV-Vis Spektrofotometrisi ile Geleneksel Bitkisel Ürünlerde (Jamu) Tıbbi Kimyasalların Doğrulanması

Estimation of thiamine hydrochloride and sulphite using charge transfer complex reaction

Metamizole (Dipyrone) and the Liver: A Review of the Literature

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