Simultaneous determination of guanine and adenine on CuO shuttle-like nanocrystals/poly(neutral red) film on glassy carbon electrode

Abstract

CuO shuttle-like nanocrystals on a poly(neutral red) glassy carbon electrode (nano-CuO/PNR/GCE) has been fabricated and used to simultaneously detect guanine and adenine. The sample is characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV). It has been shown that the oxidation peak current of guanine and adenine could be greatly enhanced with the nano-CuO/PNR/GCE. Under optimal conditions, the anodic peak current of differential pulse voltammetry is proportional to the concentration of the guanine and adenine in the range of 0.05 to 3.0 μM. The corresponding detection limits are 1.6×10 −2 μM for guanine and 2.3×10 −2 μM for adenine (S/N=3). The nano-CuO/PNR/ GCE exhibits good storage stability and reproducibility for practical application. It could be applied to simultaneously determination of guanine and adenine for the samples with good anti-interference ability.

Facile synthesis of 3D porous nitrogen-doped graphene as an efficient electrocatalyst for adenine sensing

“…7B), and the regression equation can be expressed as I pa (mA) ¼ 15.1626n (V s À1 ) + 2.0514 (R 2 ¼ 0.9937). This result indicates that the oxidation of adenine at 3D-N-GN lm occurs as an adsorption-controlled process, which is consistent with the phenomena observed at the composite lms of CuO shuttlelike nanocrystals/poly(neutral red), 42 (2,6-pyridinedicarboxylic acid)/graphene 43 and graphene/ionic liquid/chitosan. 44 The peak current is related to the surface concentration of electroactive species, which mainly depends on the adsorption capacity of the modied electrode.…”

A new sensing platform based on electrospun copper oxide/ionic liquid nanocomposite for selective determination of risperidone

“…This can be due to the fact that the nano-CuO is alkaline-oxide and its stability is improved by decreasing the solution acidity. 37 Then, the peak current was decreased and became unsymmetrical when the pH value increased from 7.0 to 8.0. Thus, in this study, all of the measurements were carried out at pH ¼ 7.0 that it is similar to physiological pH.…”

Electrochemical sensing performance of two CuO nanomaterial-modified dual-working electrodes

“…10 Moreover, shuttle-like CuO nanocrystals have been synthesized on a poly(neutral red)-modied GCE, with which the simultaneous detection of adenine and guanine was achieved. 11 Various CuO-based enzyme-free glucose sensors have been investigated using CuO nanowires, nanosheets, nanoowers, and rice-like CuO, and these sensors exhibited different sensing performance, for example, limits of detection of 0.049, 0.8, 2.5, and 0.0647 mM, respectively. [12][13][14][15] In another report, GCEs were separately modied by CuO nanoparticles, nanoplatelets, and nanorods, and their sensing effects were compared for the nonenzymatic detection of glucose.…”

“… 10 Moreover, shuttle-like CuO nanocrystals have been synthesized on a poly(neutral red)-modified GCE, with which the simultaneous detection of adenine and guanine was achieved. 11 …”