A new sensing platform based on electrospun copper oxide/ionic liquid nanocomposite for selective determination of risperidone

Arvand, Majid; Ardaki, Masoomeh Sayyar; Zanjanchi, Mohammad Ali

doi:10.1039/c5ra02554k

Cited by 15 publications

(2 citation statements)

References 44 publications

(43 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These drugs are member of fluoro butyrophenon neuroleptics and structurally related to PZ, gives a well observed oxidation peak around +1.2 in the first scan than in followed scans intermediate products give oxidation peaks around +0.6 V (Figure ). In the literature also risperidone shows similar behavior. Hence, it can be suggested that Pimozide oxidation is related to the piperidin moiety as shown in scheme .…”

Section: Resultsmentioning

confidence: 99%

NH₂‐Functionalized Multi Walled Carbon Nanotubes Decorated with ZnO Nanoparticles and Graphene Quantum Dots for Sensitive Assay of Pimozide

et al. 2019

View full text Add to dashboard Cite

In this study, a novel and sensitive electrochemical nanosensor for the determination of antipsychotic drug Pimozide (PZ) is proposed using NH2 functionalized multi walled carbon nanotubes (NH2fMWCNT) decorated with and ZnO nanoparticles (ZnONPs) co‐catalyzed by graphene quantum dots (GQDs). Prior to electrochemical analyses of PZ, the designed nanosensor was well characterized in terms of surface morphology by scanning electron microscopy (SEM) and SEM armed with EDX analysis. Electrochemical impedance spectroscopy (EIS) employed to investigate the electron transfer capability and cyclic voltammetry (CV) technique was used to successfully compare the redox response of PZ on the surface of modified and unmodified electrode. The designed nanosensor response was linear between 6.25×10−11–1.20×10−7 M concentration range of PZ with a limit of detection value as 1.02×10−11 M. The influence of interfering agents was further studied to examine the selectivity of the designed sensor. A rapid screening of PZ as is required in pharmaceutical and biological samples underscores the paramount importance of nano based electrochemical sensor for its sensitive and selective detection.

show abstract

Section: Resultsmentioning

confidence: 99%

NH₂‐Functionalized Multi Walled Carbon Nanotubes Decorated with ZnO Nanoparticles and Graphene Quantum Dots for Sensitive Assay of Pimozide

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The numbers of electrons involved in the electrooxidation (EC Ox ) and electroreduction (EC Red ) processes were determined by comparing the slope values of regression equations with Laviron's Equations ( 2) and (3) [37,38]. The number of electrons was two in both the EC Ox and EC Red processes.…”

Section: Impact Of Scan Rate Variationmentioning

confidence: 99%

2D Graphene Sheets as a Sensing Material for the Electroanalysis of Zileuton

Shanbhag

Malode

et al. 2022

Catalysts

View full text Add to dashboard Cite

Zileuton (ZLT) is an active oral inhibitor of enzyme 5-lipoxygenase, and long-term intake and overdose of ZLT cause adverse effects, leading to critical conditions in patients. This is a well-recognized issue that necessitates a better approach for ZLT sensing. Given the increasing interest in ZLT sensing and the limitations of previous techniques, there is a need for a highly sensitive, robust, and fast operation method that is inexpensive and easy to use. Thus, for the sensitive detection and determination of ZLT, an electrochemical sensor based on graphene was fabricated. Graphene has excellent properties, such as high surface area, low toxicity, conductivity, and electroactive conjugation with biomolecules, making it suitable for sensing. The electrocatalytic property of graphene promotes the redox-coupled reaction of ZLT. Electrochemical investigation of the modifier was carried out by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). An optimization and analysis of the influence of different parameters on the electrochemical behavior of ZLT were carried out using the CV approach. The scan rate study aided in exploring the physicochemical properties of the electrode process, and two electrons with two protons were found to be involved in the electrooxidation of ZLT. The fabricated sensor showed a wide range of linearity with ZLT, from 0.3 µM to 100.0 µM, and the detection limit was evaluated as 0.03 µM under optimized conditions. The analysis of spiked urine samples, with good recovery values for percent RSD, provided support for the efficiency and applicability of the developed electrode.

show abstract

Surface modification of glassy carbon electrode with the functionalized carbon nanotube for ultrasensitive electrochemical detection of risperidone

2018

View full text Add to dashboard Cite

A new sensing platform based on electrospun copper oxide/ionic liquid nanocomposite for selective determination of risperidone

Abstract: A copper oxide nanoparticle/ionic liquid nanocomposite modified electrode exhibits excellent electrocatalytic activity towards the oxidation of risperidone.

Cited by 15 publications

References 44 publications

NH₂‐Functionalized Multi Walled Carbon Nanotubes Decorated with ZnO Nanoparticles and Graphene Quantum Dots for Sensitive Assay of Pimozide

NH₂‐Functionalized Multi Walled Carbon Nanotubes Decorated with ZnO Nanoparticles and Graphene Quantum Dots for Sensitive Assay of Pimozide

2D Graphene Sheets as a Sensing Material for the Electroanalysis of Zileuton

Surface modification of glassy carbon electrode with the functionalized carbon nanotube for ultrasensitive electrochemical detection of risperidone

Contact Info

Product

Resources

About

A new sensing platform based on electrospun copper oxide/ionic liquid nanocomposite for selective determination of risperidone

Abstract: A copper oxide nanoparticle/ionic liquid nanocomposite modified electrode exhibits excellent electrocatalytic activity towards the oxidation of risperidone.

Cited by 15 publications

References 44 publications

NH2‐Functionalized Multi Walled Carbon Nanotubes Decorated with ZnO Nanoparticles and Graphene Quantum Dots for Sensitive Assay of Pimozide

NH2‐Functionalized Multi Walled Carbon Nanotubes Decorated with ZnO Nanoparticles and Graphene Quantum Dots for Sensitive Assay of Pimozide

2D Graphene Sheets as a Sensing Material for the Electroanalysis of Zileuton

Surface modification of glassy carbon electrode with the functionalized carbon nanotube for ultrasensitive electrochemical detection of risperidone

Contact Info

Product

Resources

About

NH₂‐Functionalized Multi Walled Carbon Nanotubes Decorated with ZnO Nanoparticles and Graphene Quantum Dots for Sensitive Assay of Pimozide

NH₂‐Functionalized Multi Walled Carbon Nanotubes Decorated with ZnO Nanoparticles and Graphene Quantum Dots for Sensitive Assay of Pimozide