Simultaneous determination of formononetin, biochanin A and their active metabolites in human breast milk, saliva and urine using salting-out assisted liquid-liquid extraction and ultra high performance liquid chromatography-electrospray ionization tandem mass spectrum

Zhou, Wenying; Wu, Hanqiu; Wang, Qian; Zhou, Xuefeng; Zhang, Yuan; Wu, Wenjie; Wang, Yuyang; Ren, Zhiyao; Li, Hongna; Ling, Yun; Zhang, Feng; Li, Ping

doi:10.1016/j.jchromb.2020.122108

Cited by 13 publications

(15 citation statements)

References 14 publications

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“…In contrast to the study by Franke and Custer (1996), Zhou et al (2020) found that after a Chinese woman consumed 500 ml soymilk, maximum isoflavone breastmilk concentrations were reached much earlier, after only six h. At this time point, mean genistein and daidzein concentrations were approximately 99 (270 nM) and 104 ug/kg (260 nM), respectively. These concentrations are similar to those reported by Min, Wang, and Liang (2020) for Chinese women, as genistein and daidzein concentrations in breastmilk were 144 nmol/l (38.92 ug/l) and 52 nmol/l (13.09 ug/l), respectively.…”

Section: Breastfeedingcontrasting

confidence: 76%

Neither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical data

Messina

Mejía

Cassidy

et al. 2021

Critical Reviews in Food Science and Nutrition

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Soybeans are a rich source of isoflavones, which are classified as phytoestrogens. Despite numerous proposed benefits, isoflavones are often classified as endocrine disruptors, based primarily on animal studies. However, there are ample human data regarding the health effects of isoflavones. We conducted a technical review, systematically searching Medline, EMBASE, and the Cochrane Library (from inception through January 2021). We included clinical studies, observational studies, and systematic reviews and meta-analyses (SRMA) that examined the relationship between soy and/or isoflavone intake and endocrine-related endpoints. 417 reports (229 observational studies, 157 clinical studies and 32 SRMAs) met our eligibility criteria. The available evidence indicates that isoflavone intake does not adversely affect thyroid function. Adverse effects are also not seen on breast or endometrial tissue or estrogen levels in women, or testosterone or estrogen levels, or sperm or semen parameters in men. Although menstrual cycle length may be slightly increased, ovulation is not prevented. Limited insight could be gained about possible impacts of in utero isoflavone exposure, but the existing data are reassuring. Adverse effects of isoflavone intake were not identified in children, but limited research has been conducted. After extensive review, the evidence does not support classifying isoflavones as endocrine disruptors.

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Section: Breastfeedingcontrasting

confidence: 76%

Neither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical data

Messina

Mejía

Cassidy

et al. 2021

Critical Reviews in Food Science and Nutrition

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“…In the recovery experiment, the working standard solutions were spiked at low, medium, and high concentration levels (50%, 100%, and 150% of the measured amount of each component of the sample) [37] for each compound into the samples separately and then processed and analyzed following the procedure articulated in Section 2.5. The recov-eries of all analytes in banana peel varied between 86.5-94.9% with the relative standard deviations (RSD) lower than 11.0% (data only shown for medium level) (Table 4).…”

Section: Recoveries and Relative Standard Deviationsmentioning

confidence: 99%

Profiling of Phenolic Compounds of Fruit Peels of Different Ecotype Bananas Derived from Domestic and Imported Cultivars with Different Maturity

et al. 2022

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Banana is one of the most produced and consumed fruits in the world and its fruit peel accounts for about 40% of the total fresh quantity of ripe fruit, which is usually regarded as waste and poses serious environmental hazards. However, it is a promising source of natural bioactive compounds including phenolic compounds. Determination of the phenolic compounds in fruit peel from different cultivars and subgroups over a range of maturities provides convincing information for making full use of them. This study developed a sensitive and reliable analytical method—ultra-high performance liquid chromatography—coupled with electrospray ionization tandem mass spectrometry (UPLC-MS/MS) for measuring phenolic compounds in fruit peel from different ecotype cultivars and subgroups with different maturity. The results showed that quinic acid had the highest concentration ratio among the main phenolic compounds in the green/ripe peel of all banana cultivars; among all banana cultivars, the total phenolic compound contents of green banana peel were significantly higher than that of ripe banana peel; the total phenolic compound contents in the green/ripe fruit peel of non-dessert bananas were significantly higher than that of dessert bananas (green: non-dessert banana 1.48 ± 0.44 mg/g vs. dessert banana 0.97 ± 0.12 mg/g; ripe: non-dessert banana 0.26 ± 0.13 mg/g vs. dessert banana 0.19 ± 0.06 mg/g). These data provide a basis for the rational utilization of phenolic compound extractions from banana peel with huge biomass in the next step.

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“…It is essential to remove milk protein and fat content before analysis, as previously suggested . Most previous studies have determined polyphenols in human milk after enzymatic hydrolysis and subsequent extraction with ethyl acetate or diethyl ether. − ,,, Protein precipitation with ACN has also been used in previous works to quantify total phenolic compounds in breast milk using the Folin–Ciocalteu method and isoflavones after enzymatic hydrolysis . However, in these cases, relevant information about the naturally occurring metabolites is missing.…”

Section: Discussionmentioning

confidence: 99%

“…The determination of dietary phenolics in breast milk, their metabolizing bacteria, and the metabolites produced has still been less explored. There are only a few studies, and most of them focused on isoflavones − and other flavonoid metabolites. − Little is known about the existence of urolithins or urolithin-producing bacteria in breast milk. Only the presence of glucuronide conjugates of Uro-A and Uro-B has been reported in human breast milk , from only two and one volunteer, respectively.…”

Section: Introductionmentioning

confidence: 99%

Urolithins in Human Breast Milk after Walnut Intake and Kinetics of Gordonibacter Colonization in Newly Born: The Role of Mothers’ Urolithin Metabotypes

Cortés‐Martín

Garcı́a-Villalba

García-Mantrana

et al. 2020

J. Agric. Food Chem.

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The maternal–infant transmission of several urolithins through breast milk and the gut colonization of infants by the urolithin-producing bacterium Gordonibacter during their first year of life were explored. Two trials (proof-of-concept study: n = 11; validation study: n = 30) were conducted, where breastfeeding mothers consumed walnuts as a dietary source of urolithin precursors. An analytical method was developed and validated to characterize the urolithin profile in breast milk. Total urolithins ranged from 8.5 to 176.9 nM, while they were not detected in breast milk of three mothers. The mothers’ urolithin metabotypes governed the urolithin profile in breast milk, which might have biological significance on infants. A specific quantitative polymerase chain reaction method allowed monitoring the gut colonization of infants by Gordonibacter during their first year of life, and neither breastfeeding nor vaginal delivery was essential for this. The pattern of Gordonibacter establishment in babies was conditioned by their mother’s urolithin metabotype, probably because of mother–baby close contact.

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Simultaneous determination of formononetin, biochanin A and their active metabolites in human breast milk, saliva and urine using salting-out assisted liquid-liquid extraction and ultra high performance liquid chromatography-electrospray ionization tandem mass spectrum

Cited by 13 publications

References 14 publications

Neither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical data

Neither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical data

Profiling of Phenolic Compounds of Fruit Peels of Different Ecotype Bananas Derived from Domestic and Imported Cultivars with Different Maturity

Urolithins in Human Breast Milk after Walnut Intake and Kinetics of Gordonibacter Colonization in Newly Born: The Role of Mothers’ Urolithin Metabotypes

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