Simultaneous determination of domperidone maleate and cinnarizine in a binary mixture using derivative ratio spectrophotometry and classical least squares calibration

Salem, Maissa Y.; El-Bardicy, M. G.; El-Tarras, M.F.; El-Zanfally, E. S.

doi:10.1016/s0731-7085(02)00094-8

Cited by 21 publications

(10 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This method has depended on division of the absorption spectrum of one component by the second one (as a divisor) and then the first derivative of the obtained ratio spectra was computed [31][32][33]. The overlapped spectra of LEV and EE have suggested the utilization of derivative ratio method for their determination.…”

Section: Derivative Ratio Methods (Dr)mentioning

confidence: 99%

Simultaneous determination of levonorgestrel and ethinyl estradiol in combined dosage form utilizing spectrophotometric methods and high performance thin layer chromatographic method on nanosilica gel plates

et al. 2017

View full text Add to dashboard Cite

Simultaneous quantification of levonorgestrel (LEV) and ethinyl estradiol (EE) was performed utilizing five different spectrophotometric methods and a high performance thin layer chromatographic method (HPTLC). The applied spectrophotometric methods were based on either ratio spectra namely; ratio difference, ratio subtraction and derivative ratio or the presence of isosbestic point specifically; absorbance subtraction and amplitude modulation. The proposed methods had the ability to resolve the overlapped spectra of the drugs with a linear relationship in the concentration range 1-65 µg/mL and 1-95 µg/mL for LEV and EE, respectively. The developed HPTLC method has revealed a good separation of the drugs upon utilizing Nano Silica Gel on TLC plates with fluorescent indicator 254 nm glass plates as the stationary phase and chloroform: methanol (99:1, v:v) as the mobile phase. The proposed HPTLC method has shown high sensitivity, where the linearity range was 0.02-3.00 µg/band and 0.5-20.0 µg/band, for LEV and EE, respectively. The proposed methods were successfully applied for the analysis of laboratory prepared mixtures as well as combined dosage form. Validation for all methods was conducted in compliance with the ICH guidelines proving the methods to be selective, linear, precise and accurate. The proposed methods were statistically compared with the pharmacopoeial method, where the obtained results showed no significant difference regarding accuracy and precision.

show abstract

Section: Derivative Ratio Methods (Dr)mentioning

confidence: 99%

Simultaneous determination of levonorgestrel and ethinyl estradiol in combined dosage form utilizing spectrophotometric methods and high performance thin layer chromatographic method on nanosilica gel plates

et al. 2017

View full text Add to dashboard Cite

show abstract

“…[5][6][7] Uma revisão na literatura revela que existem inúmeros trabalhos sobre métodos analíticos para determinação de cinarizina em formulações farmacêuticas. Os métodos descritos empregam as técnicas de eletroforese capilar, 8 eletrocromatografia capilar, 9 cromatografia gasosa, 10,11 cromatografia líquida de alta eficiência, [12][13][14][15][16][17][18][19] cromatografia em camada delgada, 18 cromatografia em camada delgada de alta eficiência, 20,21 métodos eletroquímicos, [22][23][24][25][26] espectrofotometria, 16,17,19,[26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] quimioluminescência, 42 fluorimetria 43,44 e espectrodensitometria. 19 Além dos métodos mencionados acima, ensaios de dissolução para comprimidos de cinarizina utilizando detecção potenciométrica ou por cromatografia líquida de alta eficiência também são descritos.…”

Section: Introductionunclassified

Estabelecimento de condições para ensaio de dissolução de cápsulas de cinarizina empregando planejamento fatorial

Gehring¹,

Santos²,

Pereira³

et al. 2011

Quím. Nova

View full text Add to dashboard Cite

Recebido em 5/7/10; aceito em 21/10/10; publicado na web em 26/1/11 ESTABLISHMENT OF DISSOLUTION TEST CONDITIONS FOR CINNARIZINE IN PHARMACEUTICAL CAPSULES USING FACTORIAL DESIGN. This work describes the establishment of dissolution test conditions for 75 mg cinnarizine capsules using a multivariate approach. A 2 3 full factorial design was carried out to achieve the best conditions and HCl 0.1 mol L -1 as dissolution medium, basket as apparatus at 100 rpm and collect time at 30 min were considered adequate. The quantification was carried out by spectrophotometry at 251 nm. Both dissolution procedure and analytical method were validated and all parameters were within the acceptable limits. Since there is no official monograph for this pharmaceutical product, this dissolution test could be applied for quality control routine.

show abstract

“…Among these techniques are the multivariate calibration methods which can be performed with easily accessible statistical software and they are currently widely used in pharmaceutical analysis (Palabiyik et al, 2004;Dinc et al, 2005;Mohamed and Salem, 2005;Salem et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Classical least squares (CLS), partial least-square regression (PLS) and principal component regression (PCR) are the most commonly used methods (Palabiyik et al, 2004;Dinc et al, 2005;Mohamed and Salem, 2005;Salem et al, 2002). On the other hand, derivative spectrometry is a fast, simple and rapid technique which is useful for determination of drugs in multicomponent systems as well as in single component formulations in presence of interfering excipients (Tomsu et al, 2004;Catherine et al, 2004;Palabiyik et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Determination of lamivudine and stavudine in pharmaceutical preparations using chemometrics-assisted spectrophotometry

Mohamed

Mikre

2009

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

A simple chemometrics-assisted spectrophotometric method for the simultaneous determination of lamivudine and stavudine in pharmaceutical tablets is described. The UV absorption spectra of the studied drugs, in the range of 200-310 nm, showed a considerable degree of spectral overlapping ([Di ](0.5) = 94.9%). Resolution of the mixture has been accomplished by using classical least-squares regression analysis (CLS) and principle components regression analysis methods (PCR). Beer's law was obeyed for both drugs in the general concentration ranges of 2-12 and 3-15 μg ml(-1) for lamivudine and stavudine, respectively. The proposed methods were successfully applied for the determination of the two drugs in laboratory prepared mixtures. The overall recoveries percent were found 98.58 ± 1.53-101.30 ± 1.35 (CLS) and 98.62 ± 1.65-101.13 ± 1.04 (PCR) for lamivudine and 98.43 ± 1.62-99.42 ± 1.55 (CLS) and 98.23 ± 1.97-101.20 ± 1.79 (PCR) for stavudine, respectively. The commercial tablets percentage content was found 98.10 ± 2.5-102.47 ± 2.94 (CLS) and 99.12 ± 1.71-100.92 ± 1.54 (PCR) for lamivudine and 96.00 ± 2.94-98.17 ± 1.72 (CLS) and 97.40 ± 1.55-97.80 ± 1.92 (PCR) for stavudine, respectively. Good percentage recoveries and proper statistical data obtained with both the laboratory prepared mixtures and the commercial tablets proved the suitability and efficiency of the proposed procedures for routine analysis and quality control purposes with quite satisfactory precision. A comparison of the obtained results from CLS and PCR were also performed with those obtained from reported method. The obtained F- and t-values obtained indicating no significant differences between the results of the proposed and reported methods.

show abstract

Simultaneous determination of domperidone maleate and cinnarizine in a binary mixture using derivative ratio spectrophotometry and classical least squares calibration

Cited by 21 publications

References 16 publications

Simultaneous determination of levonorgestrel and ethinyl estradiol in combined dosage form utilizing spectrophotometric methods and high performance thin layer chromatographic method on nanosilica gel plates

Simultaneous determination of levonorgestrel and ethinyl estradiol in combined dosage form utilizing spectrophotometric methods and high performance thin layer chromatographic method on nanosilica gel plates

Estabelecimento de condições para ensaio de dissolução de cápsulas de cinarizina empregando planejamento fatorial

Determination of lamivudine and stavudine in pharmaceutical preparations using chemometrics-assisted spectrophotometry

Contact Info

Product

Resources

About