Simultaneous determination of citalopram, fluoxetine and their main metabolites in human urine samples by solid-phase microextraction coupled with high-performance liquid chromatography

Unceta, Nora; Gómez‐Caballero, Alberto; Sánchez, Ángel Galán; Millán, Silvia; Sampedro, M. Carmen; Goicolea, M. Aránzazu; Sallés, Joan; Barrio, Ramón J.

doi:10.1016/j.jpba.2007.11.048

Cited by 72 publications

(35 citation statements)

References 50 publications

(70 reference statements)

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“…In spite of the reduced sample number, the determined urinary concentrations could suggest that the steady-state concentration in plasma has been achieved [7]. Further studies should be done to complement this work.…”

Section: Clinical Application Of the Developed Methodsmentioning

confidence: 89%

An improved analytical strategy combining microextraction by packed sorbent combined with ultra high pressure liquid chromatography for the determination of fluoxetine, clomipramine and their active metabolites in human urine

Alves

Gonçalves

Conceição

et al. 2015

Journal of Chromatography A

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Section: Clinical Application Of the Developed Methodsmentioning

confidence: 89%

An improved analytical strategy combining microextraction by packed sorbent combined with ultra high pressure liquid chromatography for the determination of fluoxetine, clomipramine and their active metabolites in human urine

Alves

Gonçalves

Conceição

et al. 2015

Journal of Chromatography A

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“…Thus using the direct immersion approach, which means to expose the fibre to the sample in solution, e.g., antidepressants (mirtazapine, citalopram, paroxetine, duloxetine, fluoxetine and sertraline) were determined in plasma samples using poly(pyrrole) film SPME and HPLC-UV [214]. Further, clenbuterol in human urine and serum [215] as well as citalopram, fluoxetine and their main metabolites in urine [216] were determined without a derivatization step, then followed by subsequent Fig. 5.…”

Section: Solid Phase Microextraction (Spme)mentioning

confidence: 99%

A review of current trends and advances in modern bio-analytical methods: Chromatography and sample preparation

Nováková

Vlčková

2009

Analytica Chimica Acta

495

231

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“…However, analytical performances in terms of extraction efficiency and detection limit were varied because of the different techniques used in these studies [1][2][3][4]12] for extraction, chromatography, and detection.…”

Section: Introductionmentioning

confidence: 99%

Electrosynthesis of polypyrrole on steel fiber for solid-phase microextraction of citalopram in serum

2012

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A solid-phase microextraction (SPME) technique using steel fiber coated with polypyrrole (PPY) was developed for UV-Vis determination of citalopram in blood serum. The coating was prepared using a three-electrode electrochemical system from an acetonitrile/aqueous (ACN/H(2)O) oxalic acid solution containing 0.01 M of pyrrole monomer by applying a potential range (0-1.3 V) for 25 min. In order to obtain an efficient film of PPY, experimental parameters related to the coating process were optimized, specifically deposition potential, concentration of monomer, and number of cycles. The effects of various parameters on the efficiency of the SPME process such as extraction time, stirring speed, adsorption and desorption temperature, desorption solvent, and pH of desorption solution were also studied. The coating was stable and adhered to the surface of the steel fiber. The method was linear over about three orders of magnitude with an average correlation coefficient of 0.97. Spiking of blank samples with 0.2 μg/mL citalopram afforded a recovery of 84% with a precision of 10.2%. A limit of detection of 0.046 μg/mL (based on S/N = 3) was obtained in the linear dynamic range of 0.046-2.0 μg/mL. The proposed method was applied to monitor citalopram in serum samples.

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Simultaneous determination of citalopram, fluoxetine and their main metabolites in human urine samples by solid-phase microextraction coupled with high-performance liquid chromatography

Cited by 72 publications

References 50 publications

An improved analytical strategy combining microextraction by packed sorbent combined with ultra high pressure liquid chromatography for the determination of fluoxetine, clomipramine and their active metabolites in human urine

An improved analytical strategy combining microextraction by packed sorbent combined with ultra high pressure liquid chromatography for the determination of fluoxetine, clomipramine and their active metabolites in human urine

A review of current trends and advances in modern bio-analytical methods: Chromatography and sample preparation

Electrosynthesis of polypyrrole on steel fiber for solid-phase microextraction of citalopram in serum

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