Simultaneous Determination of Cinnamaldehyde, Eugenol and Paeonol in Traditional Chinese Medicinal Preparations by Capillary GC-FID

Yu, Bing-Sheng; Lai, Shu-Guang; Tan, Qiao-Lin

doi:10.1248/cpb.54.114

Cited by 25 publications

(11 citation statements)

References 25 publications

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“…Based on these considerations, the simultaneous analysis of cinnamaldehyde and benzaldehyde are very important. Trans-cinnamaldehyde has been determined by spectrofluoromety (Tsai and Chen 1984), highperformance liquid chromatography (HPLC; Katayama, Mukai, and Taniguchi 1990;Lee et al 1995;Okamura et al 1999), micellar electrokinetic chromatography (Huang, Kuo, and Hsieh 1997), and gas chromatography (Friedman, Kozukue, and Harden 2000;Yu, Lai, and Tan 2006;Blakemore and Thompson 1983). Also, the benzaldehyde was analyzed by several methods such as differential pulse polarography (Kazemifard et al 2002), HPLC (Shemesh, Karschimkus, and Rowley 2005), gas chromatography (GC; Kazemifard et al 2003;Hignite, Shen, and Azarnoff 1978), and derivative ultraviolet (UV) spectrometry (Hewala 1993).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Trans-Cinnamaldehyde and Benzaldehyde in Different Real Samples by Differential Pulse Polarography and Study of Heat Stability of Trans-Cinnamaldehyde

Gholivand

Ahmadi

2008

Analytical Letters

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A simple, sensitive, and accurate differential pulse polarography method for simultaneous determination of trans-cinnamaldehyde and benzaldehyde in food and drug samples were developed. DC polarography, CV, and coulometric techniques were used for investigation the electrochemical behavior of both compounds. In phosphate buffer (pH ¼ 8.2) and 10% v=v of methanol the differential pulse voltammograms of trans-cinnamaldehyde (À1.05 V) and benzaldehyde (À1.31 V) display reproducible peaks. Under these conditions a strict linearity between both analyte concentrations and their peaks height were observed. The detection limits were calculated to be 2.5 Â 10 À8 and 1.2 Â 10 À8 M for trans-cinnamaldehyde and benzaldehyde in pH ¼ 8.2, respectively. The relative standard deviations for 1.0 Â 10 À6 M of both analytes were 2.04 and 1.18. The heat stability of trans-cinnamaldehyde was studied, and it was found that trans-cinnamaldehyde undergoes a heat-induced decomposition at low temperature (>70 C) to produce benzaldehyde.

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Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Trans-Cinnamaldehyde and Benzaldehyde in Different Real Samples by Differential Pulse Polarography and Study of Heat Stability of Trans-Cinnamaldehyde

Gholivand

Ahmadi

2008

Analytical Letters

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“…For example, some research groups reported that flavoring additives in food could also be detected by GC and GC-MS, such as menthol in food 6 , eugenol in fish and shrimp muscle tissue 7–10 as well as vanillin in fruit juice and milk powder 1,11 . Additionally, GC and GC-MS have been extensively applied for other assay fields, such as determination of eugenol in traditional Chinese medicine 12 , menthol and methyl salicylate in human plasma 13 , vanillin and ethyl vanillin in vanilla extract products 14 , methyl salicylate in ulmus pumila leaves 15 , and menthol in traditional Chinese medicinal herbs 16 . Nevertherless, previously reported methods mainly focused on the detection of one flavor agent in food, and the challenging of the parallel detection of several flavor agents was rarely addressed.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous detection of five flavoring agents in chewing gum by ultrasound-microwave synergistic extraction coupled with gas chromatography

Liu

Liang

et al. 2019

Sci Rep

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So far, the identification and determination of flavor additives in food has gained extensive attention in the area of food safety. However, it remains a big challenge for simultaneous detection of diverse flavor agents. In this work, a novel gas chromatography method coupled with ultrasound-microwave synergistic extraction was developed for simultaneous detection of five flavor compounds, including butyl butyrate, menthol, methyl salicylate, eugenol and vanilline. In this strategy, ultrasound-microwave synergistic extraction was used to extract the five flavoring agents from chewing gum. The effects of extractants, solid-liquid ratio, extraction time and microwave power on extraction yield were researched by using orthogonal test. After the optimization of programme temperature and splitless injection, the five flavoring agents were well separated and simultaneously detected with wide linear ranges, low limits of detection, high accuracy and good repeatability. Therefore, this proposed method would hold great promise for assay application on the food safety.

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“…Chromatographic techniques like liquid chromatography – mass spectrometry, gas chromatography – mass spectrometry, high – performance liquid chromatography, and ultra – performance liquid chromatography – electro spray mass spectrometry have been used earlier to determine paeonol in plant samples and in biochemical analysis. Capillary electrophoresis has also been used for the simultaneous determination of paeonol with cinnamaldehyde and eugenol . Quantum dots based fluorescence quenching method has been used for the determination of paeonol in ointment ,.…”

Section: Introductionmentioning

confidence: 99%

An Electrochemical Comparison of Single‐Walled and Multi‐Walled Carbon Nanotubes Utilizing Paeonol as the Model Drug

Mane

Chatterjee

2018

ChemistrySelect

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Herein, we report the development of a selective and highly sensitive electrochemical sensing of paeonol at carbon nanotubes modified glassy carbon electrode (GCE). Trace amount of paeonol was quantitated by employing square wave voltammetry technique for the first time based on the electrochemical oxidation of the analyte at the modified electrodes. The single walled carbon nanotubes (SWNTs) based sensor exhibited higher recognition ability of paeonol in comparison with the multi walled carbon nanotubes (MWNTs) based sensor. The linear dynamic range was found to be 100 nM – 25 μM for SWNTs modified GCE and 1–25 μM for MWNTs modified GCE. The sensitivity at SWNTs modified GCE was ∼ 3.5 times more than that at MWNTs modified GCE. The limit of detection was estimated to be 9.57 nM and 0.63 μM corresponding to SWNTs and MWNTs modified GCE respectively. The influence of experimental parameters affecting sensor response was optimized. The stability, reproducibility tests and interference effects were demonstrated to confirm the reliability of the proposed sensor. The applicability of the developed sensor was successfully assessed through convenient measurements of paeonol in biological samples and Cortex moutan which exhibits anticancer effect.

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Simultaneous Determination of Cinnamaldehyde, Eugenol and Paeonol in Traditional Chinese Medicinal Preparations by Capillary GC-FID

Abstract: Key words GC; cinnamaldehyde; eugenol; paeonol; traditional Chinese medicinal preparation through a 0.45 mm membrane filter for GC analysis.

Cited by 25 publications

References 25 publications

Simultaneous Determination of Trans-Cinnamaldehyde and Benzaldehyde in Different Real Samples by Differential Pulse Polarography and Study of Heat Stability of Trans-Cinnamaldehyde

Simultaneous Determination of Trans-Cinnamaldehyde and Benzaldehyde in Different Real Samples by Differential Pulse Polarography and Study of Heat Stability of Trans-Cinnamaldehyde

Simultaneous detection of five flavoring agents in chewing gum by ultrasound-microwave synergistic extraction coupled with gas chromatography

An Electrochemical Comparison of Single‐Walled and Multi‐Walled Carbon Nanotubes Utilizing Paeonol as the Model Drug

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