Simultaneous determination of calycosin-7-O-β-d-glucoside, ononin, astragaloside IV, astragaloside I and ferulic acid in rat plasma after oral administration of Danggui Buxue Tang extract for their pharmacokinetic studies by liquid chromatography–mass spectrometry

Simultaneous determination of six hydrophilic components in rat plasma after oral administration of Jitai tablet by liquid chromatography–electrospray ionization–tandem mass spectrometry: Application to a pharmacokinetic study

“…It is well known that LC-MS is an effective approach for the PK study of compounds in complex matrix samples. Many studies also developed LC-MS methods for PK evaluation of these six compounds [25][26][27][28][29][30]. However, these methods usually focused on only one or two main marker components separately, no global methodology could be given for a comprehensive PK study of JTT.…”

Identification of metabolites of Danggui Buxue Tang in rat urine by liquid chromatography coupled with electrospray ionization time‐of‐flight mass spectrometry

“…14 The pharmacokinetics and metabolism of multi-constituents in DBT have been reported in recent studies. 15, 16 Wang et al developed a method that used single quadrupole mass spectrometry (MS) with an atmospheric pressure chemical ionization source to study the multiple absorbed components and metabolites in rabbit plasma after oral administration of DBT. 16 However, most of the DBT metabolites remained undetected due to the limitations of the analytical technique.…”

Compatibility art of traditional Chinese medicine: From the perspective of herb pairs

“…When the two herbs are boiled together for medicinal usages, the active components could get better dissolution rate and some new compounds may emerge. Until now, many advanced technologies including HPLC-DAD/MS (Wen et al, 2008;Wang and Liang, 2010) and ultra-fast HPLC-time-offlight mass spectrometry (UPLC-TOF/MS) ) are applied in analyzing the constitutes of DBD. Since saponins account for more than 2% total dry weight of AR (Dong et al, 2003), when AS is boiled together with AR, AR could help increase the solubility of the active compounds of AS.…”